ID A0A094CNH8_9PEZI Unreviewed; 855 AA.
AC A0A094CNH8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Beta-mannosidase B {ECO:0000256|ARBA:ARBA00041069};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase B {ECO:0000256|ARBA:ARBA00041614};
GN ORFNames=V497_06898 {ECO:0000313|EMBL:KFY55549.1};
OS Pseudogymnoascus sp. VKM F-4516 (FW-969).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420910 {ECO:0000313|EMBL:KFY55549.1, ECO:0000313|Proteomes:UP000029268};
RN [1] {ECO:0000313|EMBL:KFY55549.1, ECO:0000313|Proteomes:UP000029268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4516 (FW-969) {ECO:0000313|Proteomes:UP000029268};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. Beta-
CC mannosidase B subfamily. {ECO:0000256|ARBA:ARBA00038429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY55549.1}.
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DR EMBL; JPJZ01001148; KFY55549.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094CNH8; -.
DR STRING; 1420910.A0A094CNH8; -.
DR HOGENOM; CLU_005015_1_1_1; -.
DR OrthoDB; 2504097at2759; -.
DR Proteomes; UP000029268; Unassembled WGS sequence.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000029268}.
FT DOMAIN 199..303
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 693..782
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
SQ SEQUENCE 855 AA; 97591 MW; 79899C6305F7FD50 CRC64;
MAGYINQTLS SGWEFKQVGA TEVPEWTNGF LPVAQFPTNV HLDLMAHDKI PDPFIGLNEY
KVQWVGEQQW LYRTTFECHS IPGQKTVLQF DGLDTFAIVS LNGTKILEAE NMHRIFRVDI
TGTVKNGANV LEILFDSAII RGKQLMKDTG FKPVGFTSST DKSRLLVRKA QYHYAWNWGP
ELTTCGPWRP IHLEQYSARI SDVYAKVDIC VADKTSSISI SAEIEDGKEG DIIKYALTGP
DGTTLSTSSV KVTGNKATDL FEVQDARFWW PVGFGEQPLY TVDAQLIREE ISIHQRSRKI
GLRTVSLVQR PIIDQPGTSF FFEVNGVPIF SSGSNWCPAD HFAPRVTPER YRTLLQMAID
GNQNMLRVWG GAIYEDDVFY DICDELGLLV WNDFMFACGT YPADEDFRGR ITEEVEDNLK
RLRHHPSIVA WSGNNEDYLF AELFHTNYDI KDPDPENWLK TTFPARYMYE KMLPEICKKL
IPDIPYHPGS PWGGKYFNDP TIGDTHMWEV WHHVSRPWQE YPKLGSRFIS EFGISSLPHI
DTIESFLSDS PPSERHPNSR TIDHHNKELQ HERKMATYLV ENFKYGFGLE EYIYITQLNQ
AEAMTCAMRA WRREWKGTGR EYCGGSLIWQ FNPTWQVTSK ALVDYFNRPK MAYFTVKRDI
APMCLGMERK EIKTPRSEFT RAFIDTETRI LGWATNVTLK PVSYLLTIKA FELSTGKELF
SQTKSQELGA NTTTELFDME LPEPCIVDEP VIMSTCLQTV PSDGSQGTIV ARCTNWPQPY
RYIDMPKPKL IIGIDGDKIS ARANVPVKGL AFYAKDVDGV SFGDNMLDLV PGDMQEIVAR
GLNGRAVTWR YYGME
//
