ID A0A094CNL8_9PEZI Unreviewed; 957 AA.
AC A0A094CNL8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN ORFNames=V496_06899 {ECO:0000313|EMBL:KFY55751.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY55751.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY55751.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
CC -!- SIMILARITY: Belongs to the FAH family. {ECO:0000256|ARBA:ARBA00010211}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY55751.1}.
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DR EMBL; JPJY01001301; KFY55751.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094CNL8; -.
DR STRING; 1420909.A0A094CNL8; -.
DR HOGENOM; CLU_011123_0_0_1; -.
DR OrthoDB; 1584852at2759; -.
DR UniPathway; UPA00139; UER00341.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR CDD; cd11066; CYP_PhacA-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 19..128
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 158..406
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 957 AA; 105879 MW; 504C8BFB99037AB7 CRC64;
MVALKSWLEI PADSHFSIAN IPFGIISTEA QEQKRPAVAI GDYALDLQCF AKNDGFSGLP
SIQDKLSVFG EPTLNAFAAL GRPVHKQVRE YLQDVFSEGS SSSKVLKDNE ELKKEALVPR
SKAKLHLPMQ IGDYTDFFAG INHAFNVGTM FRGPANALQK NYTHLPVGYH GRASSVVVSG
TPIRRPNGQV ILDPSKPDEP TYTACKRLDI ELELAAFVCT PNKQGEPIPV GTAEDNLFGL
VLMNDWSARD IQTWEYVPLG PFNAKNFGTS ISPWVVLMDA LEPFRTKALE NSTELTAYLK
ESREDRAYDI KLEIDLTTSD GTSTTISKTT AANLLWSFPQ MLAHHTVGGC PMNTGDLLGS
GTISGTERDT LGSLLEINRA GKDEVKLSNG EVRKFLVDGD TITIRGACGV EKGQLVIAAL
ELILASVLNL PPATSSSKMG YQIVGVAIAA AIYLFIKYLN HTDTPKIKNL PEVPGLPLFG
SLLKFGSDHA TAAYNYSKTY GPVFQVRLGN RRIVFANTFD SVRHLWITNQ SALISRPTLH
TFHTVVSSSQ GFTIGTSPWD ESCKNRRKAA ATALNRPAVQ SYMPILDLES NVSIKEIFQD
SKDGSVDIDP IAYFQRFALN TSLTLNYGSR IDGNIDDELL QEICHVERVV SNFRSTSNNW
QDYIPLMRLW PSSSKGPKEY RARRDKYLSF LLSRLKDEIA RGVDKPCITG NILKDPEAKL
STDEIKSICL TMVSAGLDTV PGNLIMGIAY LSSPHGQEIQ KRAYDEIMKV YPDGDAWEKC
ILEEKVPYVT AFVREVLRFF IVIPICLPRT SIKDIKYENA VIPAGTTFYM NAWAADYDET
HFKSPQEFSV ERYLDNLEGS GGTPHFAYGA GSRMCAGSHL ANRELFVAFV RLISAFHIDP
AKKPEDLPIL DALGCNDIPT SLTTEPKKFK CGFRARDTES LKQWIQGSED KTRHLST
//
