ID   A0A094D473_9PEZI        Unreviewed;       754 AA.
AC   A0A094D473;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=CNNM transmembrane domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=V497_04552 {ECO:0000313|EMBL:KFY59008.1};
OS   Pseudogymnoascus sp. VKM F-4516 (FW-969).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420910 {ECO:0000313|EMBL:KFY59008.1, ECO:0000313|Proteomes:UP000029268};
RN   [1] {ECO:0000313|EMBL:KFY59008.1, ECO:0000313|Proteomes:UP000029268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4516 (FW-969) {ECO:0000313|Proteomes:UP000029268};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY59008.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JPJZ01000919; KFY59008.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094D473; -.
DR   STRING; 1420910.A0A094D473; -.
DR   HOGENOM; CLU_011310_3_0_1; -.
DR   OrthoDB; 248389at2759; -.
DR   Proteomes; UP000029268; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010960; P:magnesium ion homeostasis; IEA:InterPro.
DR   CDD; cd04590; CBS_pair_CorC_HlyC_assoc; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   InterPro; IPR045095; ACDP.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR002550; CNNM.
DR   InterPro; IPR044751; Ion_transp-like_CBS.
DR   PANTHER; PTHR12064; METAL TRANSPORTER CNNM; 1.
DR   PANTHER; PTHR12064:SF100; PROTEIN MAM3; 1.
DR   Pfam; PF01595; CNNM; 1.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   PROSITE; PS51846; CNNM; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}; Reference proteome {ECO:0000313|Proteomes:UP000029268};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU01193};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU01193}.
FT   TRANSMEM        62..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          58..238
FT                   /note="CNNM transmembrane"
FT                   /evidence="ECO:0000259|PROSITE:PS51846"
FT   DOMAIN          257..319
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          323..384
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   REGION          434..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          545..754
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..595
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..625
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        655..686
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   754 AA;  80963 MW;  BEC31B92D40EBEE2 CRC64;
     MTIRPHNTRY NVAAGGTRPA VVGLAKVLFL AASQLSLAGA APLTSWIKGH EDLPKSPDDP
     DLWLYLTVAM ILVVSGGAFA GLTIALMGQD GIYLQVIATS GEGKEQKHAQ RVFKLLKRGK
     HWVLVTLLLA NVIVNETLPI VLDRSLGGGW PAVLVIFGEV IPQSICVRYG LQIGSVMAPF
     VLVLMYLLAP IAWPTAKLLD HLLGEDHGTV YKKSGLKTLV TLHKTLGSTP GDRLNQDEVT
     IISAVLDLKD KAVGDIMTPM GDVFTMSVET VLDEETMDAI LSAGYSRIPI YEPGNENNFI
     GMLLVKMLIT YDPEDCKKVG EFALATLPET SPETSCLDIV NFFQEGKSHM VLVSEYPGED
     HGAIGVVTLE DVIEELIGEE IIDESDVYID VHKAIRRLAP APTYRRAAKG QIVADNDVPK
     LQGLQGSPVV AADENYKDGG SRRRHLSLDG KTPSQSPVTF GTSPKATFMI RRSSANADGG
     SVTVRGNAAD MREHLKHLGP SNVASRPKTT RYNTVKIKPG VVKDAKDHRT SVHEDHVVFQ
     DDSEMYSAPY GGEGEGLLQS AGRPASDGVL ALQQGYGSMD HGPTHRTSSP LRKSQQADID
     EPDKSQYTKG LPSTGTVTSP QSPPRRPELH ESDSGGTISS LRSGYAGTAP RKRGTARSGS
     ITENIVDSNG VRKVVLQTTS SSDGDDAIHS QDGEDGARNR GETNVNVQLV EPRPESGGAS
     DGHAEVDDVK KKTKRRRKRK NHKDGDGGGP SGDA
//