ID A0A094D9D5_9PEZI Unreviewed; 1089 AA.
AC A0A094D9D5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=DNA polymerase alpha/delta/epsilon subunit B domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V496_04228 {ECO:0000313|EMBL:KFY63066.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY63066.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY63066.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY63066.1}.
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DR EMBL; JPJY01000686; KFY63066.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094D9D5; -.
DR STRING; 1420909.A0A094D9D5; -.
DR HOGENOM; CLU_008517_0_0_1; -.
DR OrthoDB; 911690at2759; -.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR CDD; cd07387; MPP_PolD2_C; 1.
DR Gene3D; 2.40.50.430; -; 1.
DR Gene3D; 3.60.21.50; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR040663; DNA_pol_D_N.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR041863; PolD2_C.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF2; PURINE PERMEASE C1399.01C-RELATED; 1.
DR Pfam; PF18018; DNA_pol_D_N; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 77..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 620..757
FT /note="DNA polymerase delta subunit OB-fold"
FT /evidence="ECO:0000259|Pfam:PF18018"
FT DOMAIN 808..1042
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1089 AA; 117136 MW; 4F94FCC39F06BB9F CRC64;
MDNSINSTDG PDAIGPDPHP RKTIRQRLQR VRNGLTTREG LVGNYDYAFF FRPNLPFMEK
TGASAPFFGL NDPMPTLLAL LLGLQHALAM LGGIVTPPII ISSAIYLSAE QTQYLVSSTL
IVCGLLSLIQ ITRFHIYKTP YYIGSGVLSL AGVSFTIITV STSAFDQMYK NGFCPSAEDG
TPLPCPDAYG ALVGTSACCA LILVLISFMP AKMIQKVFPP IVTGPTVMLI GVSLIQSGFS
GWLGGSGMCM SRPDSGPYMS CPNVDAPHAL PWGSAEFVGL GFSVFVTILI CERVGSPIMK
SSSVIIGLLV GCIIAAACGY FDRSGIDAAP VASFIWVHTF KLQVYGPLVL PILAVYIITA
CEAVGDITAT CDVSQLEVQG KTYDSRIQGG LLADGFNSVL AALMTVTPMT TFAQNNGVIA
LTRCANRKAG YFCCFFLLVA GIFAKFAAAI VAIPASVLGG MTTFLFGSVA VSGLAIVAKV
PMNRRNRFIL TAALALGYGA TLTPTWFSNV FGATDNKSLQ GFLEAIILVL ETGFAVTAFI
AMLLNSIMPV EIEEVGDSGT VSSSSISKVD GAMAETKEID TGSLLRAPSN TIPEPIERLP
CEYKPLYTFD LEKDKQYRQQ YGDMYFLRLA KLKPAAEKVA AEAWAGFEIG GEEATKVERV
LDVRQGELCW VTGTIYMDMA LKPNILDDIS KDHWVSVVPP RQKYKSSDGS DSTMLEDESG
RVRLIGARLA DEMMVTGCIV SVMGTENANG DFEVIDIRTP DLAPQPARWE YSDSLKTASE
SGRKVKKQKV EDEDEEMAES RPGSGGKIAI ISGLDISGSN TGHTLQINLL LEYLLGEALD
PASQQQASQI SRLIIAGNSI VVDDSTPGGS LGNTRKATHK KYGYDSSSYN PAPTAHLDDF
LAALLPSVPV TLLPGASDPA NASLPQQPVH SAMFPQARAY GSGPLIDGEK KIGWFDAVTN
PWEGEVEGWR VLGTGGQNLD DVFKYVEGED RLAMMEAMCR WRCCAPTAPD TLWSYPFQDD
EPFVIKDCPH LYIVGSQPKF DTTVIEGPDG QMVRLIAVPR FSETGELLLV DSETLEVERV
VIDVFNGDS
//
