ID A0A094D9V4_9PEZI Unreviewed; 1275 AA.
AC A0A094D9V4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=V497_06415 {ECO:0000313|EMBL:KFY56245.1};
OS Pseudogymnoascus sp. VKM F-4516 (FW-969).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420910 {ECO:0000313|EMBL:KFY56245.1, ECO:0000313|Proteomes:UP000029268};
RN [1] {ECO:0000313|EMBL:KFY56245.1, ECO:0000313|Proteomes:UP000029268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4516 (FW-969) {ECO:0000313|Proteomes:UP000029268};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY56245.1}.
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DR EMBL; JPJZ01001107; KFY56245.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094D9V4; -.
DR STRING; 1420910.A0A094D9V4; -.
DR HOGENOM; CLU_002359_0_1_1; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000029268; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029268};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1275
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001893657"
FT TRANSMEM 265..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..736
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1069..1095
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1102..1122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1128..1153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1174..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1215..1238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 593..767
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1246..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1246..1268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1275 AA; 140219 MW; C027593335DE9239 CRC64;
MRRAWEVIAG LITLSSSAIA DPYTPIHEAG RCAIRGTCGK KSFFGPELPC PDNGLAQQPS
PETRKHLIEL CGSKWSEGPV CCEGKQLDDL ESNLKRAQPI ISACPACKEN FFNLFCTFTC
SPDQSLFINV TETEQKGDKS IVTELDQLVS VEYGSGFFDS CKDVKFGAAN QNAMDFIGGG
AKDYPGLLKF LGDKKLLVGS PFQINFPLPS DYTEPNMKPT DMVPKKCNDE DEAFRCACVD
CPAVCPKLEE VKENKACHVG PLPCLSFGAI LTYGIFLALL ATAIFGHVAW AKHSKRRNQR
LQLLQDISAS DDEDEEGDLL DNAALYDRPQ QNYKVNTIID SAFSKLGYAA ASFPGISIGF
SVLVVALLSL GWMNFDIEKN PARLWVSPTS AAAKEKAFFD ESFGPFYRAE QVFLVNDTHP
DGPGPVLSYD TLKWWFDVED RVGDLVGPKY GAKLNDVCFK PMGDACVVQS VTGYFGNDIT
TVNPNTWKSD LQACAKSPVL CRPESGQPLP PNMILGGWEE SGDVVDSTAL IATWVVNNYA
EGSPETERAM DWETSLRSLL LSLQGEAQER GLRLSFSTEI SLEAELNKST NTDAKIVVIS
YFIMFFYASL ALGSTSLSLV SLFRNPSIAL VQSKFTLGVV GIIIVLMSIS ASVGLFSALG
IKVTLIIAEV IPFIVLAVGV DNIFLIVHEF ERVNLSHPDE IVEVRIGKAL GRMGPSILLS
ASTETMAFAL GAFVGMPAVR NFAIYAAGAV FINAILQVTM FISVLALNQR RVEDNRADCF
PCVQVKSARV HLGTDINGNP RYYEGSDEGA LEKYIRKTYT PSLLGRKMKV FVVVFFFGLF
ATGVSLFPEV KLGLDQRVAI PDDSYLIPYF NDLYAYFDAG PPVYFVTRGL NATEREHQQQ
ICSRFTTCES LSLTNVLEQE RKRPEISYIA APAASWIDDY FRWLNPEEEC CMENGVPCFQ
ERDPAWNITL HGMPEGHEFV DYLQRWIKEP VNDDCPLGGK AAYGNALVID KEATTIPASH
FRTSHTPLRS QEDFIDAYAS ARRIADAVSK RTGIEVYPYS LFYIYFDQYA SIVSLTTQLL
LSALAIILLI TTLLLGSLQT AMVVTGTVAM IVTDIIGTMA LFNVSLNAVS LVNLIICIGI
GVEFCAHIAR AYTYPSVSLL ARAPASFRGR DARAWVSLVN VGGSVFSGIT ITKLLGVCVL
AFTKSKIFEL YYFRIWLALV VFAASHALVF LPVMLSLVGG DGWKDSEGDG GLEEDLTSRR
HRAFMPEDED SEEEY
//
