ID A0A094DGM3_9PEZI Unreviewed; 1360 AA.
AC A0A094DGM3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=phosphoribosylformylglycinamidine synthase {ECO:0000256|ARBA:ARBA00012747};
DE EC=6.3.5.3 {ECO:0000256|ARBA:ARBA00012747};
DE AltName: Full=Formylglycinamide ribonucleotide amidotransferase {ECO:0000256|ARBA:ARBA00032632};
DE AltName: Full=Formylglycinamide ribotide amidotransferase {ECO:0000256|ARBA:ARBA00029823};
GN ORFNames=V496_06031 {ECO:0000313|EMBL:KFY58635.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY58635.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY58635.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004920}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the FGAMS family.
CC {ECO:0000256|ARBA:ARBA00008608}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY58635.1}.
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DR EMBL; JPJY01001088; KFY58635.1; -; Genomic_DNA.
DR STRING; 1420909.A0A094DGM3; -.
DR HOGENOM; CLU_001031_0_2_1; -.
DR OrthoDB; 2891567at2759; -.
DR UniPathway; UPA00074; UER00128.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01740; GATase1_FGAR_AT; 1.
DR CDD; cd02203; PurL_repeat1; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 1.10.8.750; Phosphoribosylformylglycinamidine synthase, linker domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR HAMAP; MF_00419; PurL_1; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR040707; FGAR-AT_N.
DR InterPro; IPR010073; PurL_large.
DR InterPro; IPR041609; PurL_linker.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR036604; PurS-like_sf.
DR NCBIfam; TIGR01735; FGAM_synt; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 2.
DR Pfam; PF18072; FGAR-AT_linker; 1.
DR Pfam; PF18076; FGAR-AT_N; 1.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF109736; FGAM synthase PurL, linker domain; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR SUPFAM; SSF82697; PurS-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|PROSITE-ProRule:PRU00605};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302}.
FT DOMAIN 39..159
FT /note="Phosphoribosylformylglycinamidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF18076"
FT DOMAIN 183..232
FT /note="Phosphoribosylformylglycinamidine synthase linker"
FT /evidence="ECO:0000259|Pfam:PF18072"
FT DOMAIN 445..597
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT DOMAIN 882..995
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT ACT_SITE 1193
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1321
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1360 AA; 147935 MW; 523AA6CA02B04A00 CRC64;
MEYLTLLGED AYTSSSARKI QDLIAKTSSA KVDEVSAVYI HYARLNQGTN DVAKETDAKL
RQLLPTPRPE FFREASGASA RNFKVYYVTP RNISPWSSKA TSIAAVCGVK GLERIERGRA
ILVKFAEPFE GSDDSFKHVL FDRMTENISS SEPDVKGMFA EGQRIPLEVV DIFAEGAKPI
EILKGYNKER GLALDEPEME YLIQAYSKIG RSPYDVELFM FAQVNSEHCR HKQFNANWTI
DDVAMGKSLF EMIKNTHKNN PKYTVSAYSD NAAVLEGNFA SFWAPDYNTG SWKATKEMVH
YIIKVETHNH PTAISPFAGA ATGSGGEIRD EGAVGRGSQP KAGLCGFWVS DLLIPDFEQP
WEIDFGKPAH YASSLDIMLE APIGSARFNN EFGRPCLTGC FRTLLADTGS DEAEDYRGYH
KPIMIAGGMG TVRPQFAIKR QGDVKPGAHV IVLGGPAMLI GLGGGAASSN ASGEGSAELD
FDSVQRGNPE MERRAQMVIN ACCALHDANP IAMIHDVGAG GLSNALPELV KDAGYGGRFE
LRQIESADSS MSPLQIWCCE AQERYVLCVN EEGLNKFVNI CNRERCGFSD VGTVTGTIGD
SESTLVVTDR EGTEYPKPID LPMTTLFPRD RKLERNVKTK KNNLKAFDSF QSLCSLKTTK
SCRGSAEFIH RAMEIVLKVP AVGSKAFLIT IGDRTVGGMT TREQMVGPWQ TPVADVAVTV
TSLATGGILT GEAMAVGEKP PLALISPAAS ARMAVAESLL NLAAADIQGG LERVRLSANW
MAAVNHEGEG SALYEAVQAI GMEMCPKLGI SIPVGKDSTS MKASWKDSSN GESKSVTAPV
TVVISAFAPV QRVSHTWTPA LRRLEDVGET ILMFVDLAQG KQAMGGSAFA QACGQLGNES
PDVHDVDLIA DYFDAITQLH ESGIVLAYHD RSDGGLFTTI AEMMFAGRCG AEIMLDGVAK
SDETGDVLDA LFNEELGAVF QVKKSDEINF IRCFATCGPP PGLVKKIGRI PAASKQELSI
RYKTETITHL DRSTMQEWWS STSYQMQRLR DNPASADSEF SLIKDNKDPG LSFNLTFDPK
ESILPMTTLL SSPFIKAPRV AILREQGVNG YAEMAFAFKA AGFDAIDVHM TDIIGGRSLA
DFVGIAACGG FSYGDVLGAG QGWAKSILMH EENARPEFKK FFERKDTFAL GVCNGCQMFS
RLAELIPGAE NWPIFVDNES QQFEGRASMV QIKDNKENPS VFFHGMDGSS LPIVVSHGEG
RAQFKNNTDL EALTASGLVP IRYTDNYGKV TEKYPLNPNG SAQGIAGVSS RDGRVLAMMP
HPERTIMASV GSYIPDGMTE EWGEYGPWVR MFKSARRWVG
//
