ID A0A094DYZ1_9PEZI Unreviewed; 1185 AA.
AC A0A094DYZ1;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Linoleate 8R-lipoxygenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=V496_00222 {ECO:0000313|EMBL:KFY69453.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY69453.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY69453.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY69453.1}.
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DR EMBL; JPJY01000037; KFY69453.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094DYZ1; -.
DR STRING; 1420909.A0A094DYZ1; -.
DR HOGENOM; CLU_002329_1_0_1; -.
DR OrthoDB; 3322316at2759; -.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProt.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd20612; CYP_LDS-like_C; 1.
DR CDD; cd09817; linoleate_diol_synthase_like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR036396; Cyt_P450_sf.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR034812; Ppo-like_N.
DR PANTHER; PTHR11903:SF37; LINOLEATE 8R-LIPOXYGENASE-RELATED; 1.
DR PANTHER; PTHR11903; PROSTAGLANDIN G/H SYNTHASE; 1.
DR Pfam; PF03098; An_peroxidase; 2.
DR Pfam; PF00067; p450; 1.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00022964};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302}.
FT REGION 232..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 489
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 1185 AA; 131876 MW; FB89DF6EC8903DCE CRC64;
MSISHLHLAH VAQIAHDAPA ANLAKRPASL HIISTSRHRF TVPVTGTSRC LFRKPWFVCI
CFRVRICIAA APPMQLPSPP RHPVTTSPAD LWSSPLLPPY LQWTPPPSPN QHGPQGAYSI
PATPISQFKT LLGSIRRKPS HAPDGKTDEQ AYGKSMEEKT SILHDLTHLG VKNTKTVAEA
ITTLASGEPM DDKDLLLEKG VSMLQSLPTN SGLSQTVSNN FIGMLWKDLP HPPPTTAGPT
ARYRQPDGSG NNPWIPEMGK AGMPYSRSVP PMKPKGPNLP DPELVFDQLL KRTGPFREHP
SGLNRLFFSF ATVVIHECFQ TSRTNPLINE TSSYVDLSTI YGNNAEEQKR VRTYEQGRIF
PDSMASERIM MMPPGVVAVL LMFSRNHNHI VENLLTVNEG GKYKDWDSLD DEQKAWQDED
LFQLTRNINV GFFATVVLKD YVAAILNTPR ANSHWSLDLG GEIKNGGERL ERGSGNVVSV
EFAVLYHWHA ALSAADDQWM ESVIRKHIPD LQSIDDVTAA DFKKVMMTEG HQLMATPPKE
WTFGGLQRGP DGKFNDVDLA EIIKDCIEEP AHAFGAHSTP ASLKIVDIMG QLQARDMFNV
CTMNEFRRYL NLKPYEDFED WNPDKETARA AELLYGHIEN LELYPGLMAE VTKPAMPGSG
VCPGHTTGRG ILDDAVALVR GDRFLSYDFN STTLSNWGVA KLGAIQAGAY GGMLPHLLFN
ALPGAWTGTS TYALLPFYTP IAAKGILKGN KVLEQYDLER PASDKVVLGI HTHEGCKKVF
EDRENFRVMY QAAIRKCTDG HDFLIGWDDA KRHDTRSSIL HKVFFEEGFE ANLQKFFRTN
VSRLIKEKSL KYSNSRRSID IVRDVTNVTP ILWLAERFAI PLKTKETPHG LMSIPELFTI
YLVLFMYQSF NIIPANEWKL REGAMKAAPA LRAVFEAHLK TQQGFKEGIV DWLAKGSSFE
VGPDADRLYH ALNDSKLPIG DLVGDCIGMG APVAGNLTQQ ASLLIDLYLS EGYEEYKDRI
IELSHKDDAA SERELQGFVF EGMRHAGVVP GLPRVASKDV TVMDGSRGPI NIKAGHTILI
ATSKAAMDPI QFPNPEKLNP HRPFKDYILL GHGLHFCFGA RLVGCSLAAT LKEVFKLRNI
RRANGRQGHF SIVEHEFAGV KMRQYLDSNA NESPIPTTLT LEYDE
//
