ID A0A094E3F4_9PEZI Unreviewed; 898 AA.
AC A0A094E3F4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=GB1/RHD3-type G domain-containing protein {ECO:0000259|PROSITE:PS51715};
GN Name=SEY1 {ECO:0000256|HAMAP-Rule:MF_03109};
GN ORFNames=V499_06758 {ECO:0000313|EMBL:KFY73114.1};
OS Pseudogymnoascus sp. VKM F-103.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420912 {ECO:0000313|EMBL:KFY73114.1, ECO:0000313|Proteomes:UP000029295};
RN [1] {ECO:0000313|EMBL:KFY73114.1, ECO:0000313|Proteomes:UP000029295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-103 {ECO:0000313|EMBL:KFY73114.1,
RC ECO:0000313|Proteomes:UP000029295};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|HAMAP-Rule:MF_03109}; Multi-pass membrane protein
CC {ECO:0000256|HAMAP-Rule:MF_03109}. Note=Enriched in the cortical ER.
CC Concentrated in punctae along the ER tubules. {ECO:0000256|HAMAP-
CC Rule:MF_03109}.
CC -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_03109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY73114.1}.
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DR EMBL; JPKB01001132; KFY73114.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094E3F4; -.
DR HOGENOM; CLU_011270_0_0_1; -.
DR Proteomes; UP000029295; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:UniProtKB-UniRule.
DR CDD; cd01851; GBP; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_03109; Sey1; 1.
DR InterPro; IPR030386; G_GB1_RHD3_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008803; RHD3/Sey1.
DR InterPro; IPR046758; Sey1/RHD3-like_3HB.
DR PANTHER; PTHR45923; PROTEIN SEY1; 1.
DR PANTHER; PTHR45923:SF2; PROTEIN SEY1; 1.
DR Pfam; PF05879; RHD3_GTPase; 1.
DR Pfam; PF20428; Sey1_3HB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51715; G_GB1_RHD3; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, ECO:0000256|HAMAP-
KW Rule:MF_03109}; GTP-binding {ECO:0000256|HAMAP-Rule:MF_03109};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_03109};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_03109};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_03109};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_03109};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_03109,
KW ECO:0000256|SAM:Phobius}.
FT TOPO_DOM 1..774
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT TOPO_DOM 796..798
FT /note="Lumenal"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT TRANSMEM 799..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 820..898
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
FT DOMAIN 77..319
FT /note="GB1/RHD3-type G"
FT /evidence="ECO:0000259|PROSITE:PS51715"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 87..94
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03109"
SQ SEQUENCE 898 AA; 100959 MW; 03E63EA18B31E6CA CRC64;
MTTSPPSNGV TNSPRRPSAA SRATAPSVMT MNGHFAAVGD APTKEQYEHG IQVIDDEKEY
NPNLNTFLQQ TGTAQAGFNY HLISVFGSQS TGKSTLLNYL FGTAFGVMSE SERRQTTKGI
WMSKNKRESD DRGAHKMAEN ILVMDVEGTD GRERGEDQDF ERKSALFALA TSEVLIINIW
EHQVGLYQGA NMGLLKTVFE VNLQLFLKDK QANPRSLLFF VIRDHIGTTP LSNLQQTLIQ
DLTKIWSSLS KPKGLEKSRI EDYFDFAFAA LPHKILQPEK FEEEVLKLGT RFRAGHRVSK
PDDTHTDQEL EGGVFLPEYH RRIPADGFSV YAAGVWEQIV HNKDLDLPTQ QELLAQFRCD
EIAREVLVAF DETIAPLEEK QAEGTRLGNL IVIAELGISG LKARSAAVKA FEAEASRYHK
GVYSRKRVEL ESKIDTRLKA LYHGQLSAVH KAGVKSFSDA VGNAVKIGQK KGASYEFAEI
VEKEKTKALE TFECEAKSLA VPGVPWANFK QQYKLFEKEL DEVSARLRRE EMRRLATRIE
RWVKSRLGES VGLEFNKLGS GRGGSGAPEE GTKPTEKDLW DRIWTLFTST VKEAETRFLD
RAQSFDASES EKEVGLWRLR RKSWAVLRVR IDEEVMEGNI LLKLRENFED KFRYDDAGVP
RIWRPTDDIE GIYTKAREST LALIPLLSRF RLAESYAPPP LPDWIGHAPD AVVPDDEEDL
TPIGGVDEEE GKSLEEEMTV LSEAKRQDLV VRFKKMADGV YVEAKRSAIG GVTQVPLYFW
ALMVALGWNE IVAVIRNPIY FIFLILAGIG AYVTYTLNLW GPIIKMSNAA AQQALDIGKE
RLRDFLESND AGRQALNMAS AKEDSDNISM QSLDSRGRRK ARMARGKGED DSEEERDL
//
