ID A0A094EBS6_9PEZI Unreviewed; 751 AA.
AC A0A094EBS6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Methyltransferase type 11 domain-containing protein {ECO:0000259|Pfam:PF08241};
GN ORFNames=V496_00534 {ECO:0000313|EMBL:KFY69155.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY69155.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY69155.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the phytoene/squalene synthase family.
CC {ECO:0000256|ARBA:ARBA00006251}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY69155.1}.
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DR EMBL; JPJY01000083; KFY69155.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094EBS6; -.
DR STRING; 1420909.A0A094EBS6; -.
DR HOGENOM; CLU_021653_0_0_1; -.
DR OrthoDB; 5487739at2759; -.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004310; F:farnesyl-diphosphate farnesyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0051996; F:squalene synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00683; Trans_IPPS_HH; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002060; Squ/phyt_synthse.
DR InterPro; IPR006449; Squal_synth-like.
DR InterPro; IPR044844; Trans_IPPS_euk-type.
DR InterPro; IPR033904; Trans_IPPS_HH.
DR NCBIfam; TIGR01559; squal_synth; 1.
DR PANTHER; PTHR11626; FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE; 1.
DR PANTHER; PTHR11626:SF2; SQUALENE SYNTHASE; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF00494; SQS_PSY; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01018; Squalene/Phytoene_Synthase_Lik; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol biosynthesis {ECO:0000256|ARBA:ARBA00023011};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 684..707
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..148
FT /note="Methyltransferase type 11"
FT /evidence="ECO:0000259|Pfam:PF08241"
SQ SEQUENCE 751 AA; 84851 MW; A5CF4B545AB41715 CRC64;
MASDPTFRSY KPDQAQKYAA SRPSYPPALY EHIFAEHAAH GGGFEFLVDV GCGPGRATQD
LALSFDHAVG VDPGQEMINV ARGRGGETKQ GEQIRFEVCE AERLASVPGL PRGGVDLLTV
ATAVHWFDMK KFWEQAAQLV RPGGTVAFWV KGSYFCHPNM PHAVEVNAIQ EEFGRVIAPY
MQPGNVLAEN MYDDLELPWT VDPTQTAFPE DKFRRFNWDR GGVLSDGKDF FGGTGEFSME
LYRHALSTVS PVTRWREAHP ELVGTDQDVV EAAYLQFLYF VVHPTQLRPI IEWKLLHKPA
YTRDPSKESA TLKDCFKWLK LTSRSFVMVV QELNPDLVVP VALYYLVLRG LDTIEDDMTI
SLKEKEPLLR NFETVLDKDG WAFDKSGPDE KDRELLVHFD DVIKELKLID PKYRDIIKDI
THQMGNGMAD YARMAENDVN SVKTVEEYEL YCHYVAGLVG DGLTRFFVQD GFANPSLKTQ
PELSEAMGQF LQKTNVIRDV REDFDDKRRF WPKEIWSKHV DNFENLFDPK NREAALSCSS
EMVLNALRHA DECLAYMEGI KEQGIFNFVA IPQTMAIATL ELVFQNPKVF ETNVKITKGD
AAQLLIDSSQ DLRRVCAVFK RYARRIHQKN NPKDPNFLNI SVACAKIERY IESIYPLNDP
EPGVQLADGN LVAIDDQPKI DTPYLILAML GMLFVISAIM IGIAYSAGVR FDVVVKELAN
GNIFPGREIF FDVQQGNVND RGGHPAVYGE L
//
