ID A0A094EBW2_9PEZI Unreviewed; 2093 AA.
AC A0A094EBW2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Protein transport protein sec16 {ECO:0000256|RuleBase:RU364101};
GN ORFNames=V496_00461 {ECO:0000313|EMBL:KFY69185.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY69185.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY69185.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the initiation of assembly of the COPII coat
CC required for the formation of transport vesicles from the endoplasmic
CC reticulum (ER) and the selection of cargo molecules. Also involved in
CC autophagy. {ECO:0000256|ARBA:ARBA00024687,
CC ECO:0000256|RuleBase:RU364101}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}.
CC -!- SIMILARITY: Belongs to the SEC16 family.
CC {ECO:0000256|ARBA:ARBA00005927, ECO:0000256|RuleBase:RU364101}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY69185.1}.
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DR EMBL; JPJY01000079; KFY69185.1; -; Genomic_DNA.
DR STRING; 1420909.A0A094EBW2; -.
DR HOGENOM; CLU_001147_0_0_1; -.
DR OrthoDB; 1361743at2759; -.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:UniProt.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd09233; ACE1-Sec16-like; 1.
DR Gene3D; 1.25.40.1030; -; 1.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR InterPro; IPR024340; Sec16_CCD.
DR InterPro; IPR024468; Sec16_N.
DR PANTHER; PTHR13402; RGPR-RELATED; 1.
DR PANTHER; PTHR13402:SF6; SECRETORY 16, ISOFORM I; 1.
DR Pfam; PF12932; Sec16; 1.
DR Pfam; PF12931; Sec16_C; 1.
DR Pfam; PF12935; Sec16_N; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|RuleBase:RU364101};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU364101};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|RuleBase:RU364101}; Membrane {ECO:0000256|RuleBase:RU364101};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU364101};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW Transport {ECO:0000256|RuleBase:RU364101}.
FT DOMAIN 265..441
FT /note="Sec16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12935"
FT DOMAIN 1100..1218
FT /note="Sec16 central conserved"
FT /evidence="ECO:0000259|Pfam:PF12932"
FT DOMAIN 1278..1581
FT /note="Ancestral coatomer element 1 Sec16/Sec31"
FT /evidence="ECO:0000259|Pfam:PF12931"
FT REGION 1..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1681..1925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1941..2093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..465
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..671
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1688..1703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1721..1743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1819..1839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1840..1889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1979..1995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2022..2055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2093 AA; 222628 MW; 5F07D83D688C38F8 CRC64;
MSAVHPNASW NPAFRPDSTA TESKTESYGA INAAATEENR EIEDDTEGVP RPSTPNTETP
NQYDAATTLE HPGGNEEHPE LGSLREALTT SLGSPGGVEM DNNPSHAPET IKEEEQGQTQ
MTYDRAEIPS SGPSNTNKHM SNISFTRTVG EDVDWGEDDE VDPEWNLQSK DDDPFQSMPP
TDRTNSFPAV PPAHVANETT PNGYHSQAGD IMLREEDNTY NEPSSAPQTK KSHRVKQSID
WGTSGEYGDD EFNLGMVQGG DIGEESMEAS QYEEGVHLVQ STHLSPPVKG HKKMFSTSKL
FDDIEAEDDG GFFSTIGSDT TEQPPKLDRK STSEVLNSIS HDLHAETNGN ITDGGHESRR
AKSISATTGG GIATSKSTLI SDVLASIADT NEEAVGEDNV IEESKPSEEN LAAKWQAALD
ADEFLEDDDD LLPDEVPELT PELDPEAVFG SDDEGFLEDD EPELAIGPDS QNQIPSFPKP
ITDPNGNVIG FDQLIGSAQT TGQSAQNRYM PTAAAQTAQQ QPKNMYEPAT PLFTDLSGQF
NPAGTYGTTQ PSGQGPRPSS SGFGAQPPAA SRPDLGPKAQ SFADKTKGGY SSPYDLPMDV
TKPRKRVSMQ QMSAAYGQAP APTPPLRSNS MHIQNQPQTS PAFPSPPMGS MGPPTPSAPQ
GFQPPPKQGP PTLKSKGSSF FEELPVVAKQ RAPRAPSQPV SPSLSGLEAT GGGSPPATSM
GPPQIPPPRQ QYAESPTAAH GLVTSPPVNP YSPIVAQEPK SAPASSRYSP APVQQQPAGY
APAPVQAQSA YSPAPVQQPA TAYSPVPAQQ PSHGYSPVPV QQPSAGYSPA PAQSPATGYS
PAPVQQQPAA PPQGKYGATP PLVRHVIPPY AAAPLAPNPP FAHQPRTSSP LAQFERSSEH
EASASPPANL GYGRTGRRES SSYGNGARDA HLTLAREATE HAAIDRRRSQ DQAGLSPQES
QATSQLRPGL TAPLRSPHES GLMSPPKRSL SHAPDNREPL TEVEEPAFQP PKRSQTQSPG
SATSGPRSRV TSGEILPRPP SSSVQSPTSP PRQSRAYAPI TAEATAPTQK VHARTVSQGL
DYIEPTDGRQ HDPLQRWKGA PVFAWGSGGT VITSFPKEVP RYGMGSNIPM IQPSPGEVKV
RSIKDIYALD ERTSNFPGPL KGKAKKKDVL TWLSKGIESL ERQNDHFRSL SSLSHDDMRK
EERVVLWKIL KAFVENNGVL EANAEAEKAV RSILSPELDN EGASSAPFAI GSDLGGIHRA
AGSTILADPV DPVAVDTLRK QLLKGEREKA VWSAVDNRLW AHALLLSNTI SPDLYKRVAQ
EFVQKEVKNI GENTESLAAL YEIFAGNHEE CVDELVPPSA RAGFQMVSTS ATTGPSKSAV
EGLNHWRETL GLILSNRSAD DSKAIQSIGK LLAGYGRSEA AHICFIFARS RSVFGGIDDS
QSDIVLVGAD HQRDPYGFDK DTESILLSEI YEFGQSLSST SSVPILIPHL AVYKMQHAKL
LTAFGQKSKA LEYCEFIASS ITSQTRRSTY HHPLLVSELD DLSKRLKQSP KDETSSWIAK
PSIDKVSSSV WTKFNKFVAG DEKDEGPAGG DDISGDVGPF ARIAGGTPTI SRTPSVADIY
SQGNIPNTTS GAIPIPIGGK TVSRYAPGGS YGSNAAMGSS FGSPAGSPYA GLNIGLPIPA
PHGQQYPASD SRVLSSGSFD SRYAPTSHPE YAPAPQVAPT SHADYSPQYG ASYASSPNEY
RAPEYNQAQP PKTDGDPDGY HAPQTTGTMD PSGNYPLAPI TPSSFEPPTY NPYETQPPTS
FEAPASAGYS PPEQSGYIPP SYEPNQMNDE PSSPIDTGSK KKSFMDDEDE TPRKPSGGAG
EMTKAEKDRA ADEAFRKAAE EDEKRSSSQP QKKGWGLTGW FSKKEASPAE PQQAQPGKPI
KAKLGEASSF YYDPELKRWV NKKGGKDEQA KVGITPPPPK AGPPRSEAGS APPGMGVTSA
PRSASSSSYE STPPLRAGSP GSFAVPGTQS EPPVTVGSLE PPVLQRNFSN TSTRSVSGGS
NPSSRPNTGM SNASSIDDLL GPPVARKAGD RAKKGKKGRG YIDVMGDKAA ASG
//
