ID A0A094ECS7_9PEZI Unreviewed; 1570 AA.
AC A0A094ECS7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=phospholipase A2 {ECO:0000256|ARBA:ARBA00013278};
DE EC=3.1.1.4 {ECO:0000256|ARBA:ARBA00013278};
GN ORFNames=V499_03898 {ECO:0000313|EMBL:KFY76476.1};
OS Pseudogymnoascus sp. VKM F-103.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420912 {ECO:0000313|EMBL:KFY76476.1, ECO:0000313|Proteomes:UP000029295};
RN [1] {ECO:0000313|EMBL:KFY76476.1, ECO:0000313|Proteomes:UP000029295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-103 {ECO:0000313|EMBL:KFY76476.1,
RC ECO:0000313|Proteomes:UP000029295};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY76476.1}.
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DR EMBL; JPKB01000583; KFY76476.1; -; Genomic_DNA.
DR HOGENOM; CLU_003496_0_0_1; -.
DR Proteomes; UP000029295; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProt.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07216; Pat17_PNPLA8_PNPLA9_like3; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF12796; Ank_2; 6.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF01734; Patatin; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 16.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 8.
DR PROSITE; PS50088; ANK_REPEAT; 11.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}.
FT DOMAIN 12..223
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT DOMAIN 400..541
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REPEAT 965..997
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1024..1056
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1094..1122
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1123..1155
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1189..1221
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1326..1358
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1361..1388
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1397..1429
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1431..1463
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1466..1498
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1501..1533
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 1570 AA; 171924 MW; 2D6311C7353BB383 CRC64;
MADDSERPIR ALSLDGGGVR GLSAILILDH IMRNINTQRK ADGKDPQEPW EYFDLMGGTS
TGGIIAIMLG RLRMTIPECI KAYTELSKAI FTPRHSRASP VRGVEYLNGD GKFDSLALER
EIKNQIRKSK VAKNDDQILL QDPESPCKVC VFALRESNSK LAILRTYDYL HASQTLFDEC
KVWEACRATS AAPTFFDPVQ IGQYKQSFID GGLGYNNPIF KVYDEAQNIW PDRTVVATSI
GTGEVPGTAF GGNLKKIAES ITKIVTGCDV VADDFYNANK VMVAEERYCR LSVTHGLGNI
GLEEHKHIGE IVDQTQEYLS RGEPQAKLKQ CIKALLQERV NNGNDIYLLS GLQTPETCLE
SLQFKEMNFR KENIVNADDN TCGWLLENEN YACWIQNTDG LLWIQGKAGA GKSTLMKYIY
EKIQMPTVST SSLKLSFFFH ARGTELQKTP LGMFKSLLLQ LYKGDSTART GIIKEFNKNS
EEGMVNVKWE WTEKMLEELF SSLICQISQS KKVTIFIDAL DEAGEVIAND LATYLASLYE
KVQHNNGIVK ICFSSRHYPI VSTRVAENQK VIVEHENGRG IRLFIQREFE QNLQDDGPIK
SKAMSLKLED DIAAKANGVF QWVCLVLPII FKADREAEPL GSIQNILYDL PKDLNDMYRY
ILQALISQKQ KTGALKLFRW VCFAARPLSL EEIRHAMAVV DSLPPLQLYH LKDSSEYVEY
RMETRITALS GGLIEVREHD SGTVVQVNHQ TVRDFLLEEG FEILTGLKTP SDTEKKKFEG
SCHDILARSC VNYLWTEDVQ QHSTTTIIKK SSSKRTWIQL PALETLPLLQ YAIAAYFWHA
SKAEQNGHYQ ETLLDQFDYK HTYRFPKRDI VEQGLFSLWC SAGKIFCPRD YLGVLPSESS
TLLHIASMAN IPTAVRSLLK KKVKVSEKDN LGQQAIHYAA RGGATEAAGI LIKFSSSVIN
AKDNNALTPL QIASRHYKAD VLRLLISKGA TIKCFDKQNS TKLGKVRGNV EKTVSLLLED
GAKFNAQSLQ SAAADGNLEA VRLLLAEGTD VNGLSGEYGY ALVAAAHNGH EAMALGLLKN
GAEVNAHGGI YGCALVAAAE SGDEKMVYIL LQAGAEVNAK GGKYAGALEA AAAMGHANMV
KILLKRGANV NTQKGKYGGA LASAACAGHA EVVEILVEGG ANINAQIGTY DNALTAAVSC
GHEAVVKILL ERGAKPDALS GGKTNPLAIA AMGNHFDIAQ ALLKAKAKCK PFLAEVKFFG
KYDLQRSLEL VLLLASLVGR LDIVDGIIAF NERNDHPLSD LTAMNYWLLQ YGRLNANAYS
KILQYNGYTA LQLSAAGGHP EVAARLITAG SDVNDFSDFP RGHSALQVAA KHGHLEVVKI
LLTAGANVRN IPVFYGQGLS ALQLAAKHGH LEIVKTLLTA GANVEAALAK HSETALQTAV
RHGHLKIVEL LLDSKANPNA TPHGDQGPTA LEIAAEKGNL EAVDMLLKAG ADVDAPGLTY
GPGAALHGAA CHGHTDVIAR LIAGGADVNL RAPDGYRAIY RLGPWDMDTL GWSSYRDRQE
QNKSLDPSMV
//
