ID   A0A094ERU1_9PEZI        Unreviewed;       646 AA.
AC   A0A094ERU1;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=NAD-dependent epimerase/dehydratase domain-containing protein {ECO:0000259|Pfam:PF01370};
GN   ORFNames=V500_11406 {ECO:0000313|EMBL:KFY81461.1};
OS   Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY81461.1, ECO:0000313|Proteomes:UP000029284};
RN   [1] {ECO:0000313|EMBL:KFY81461.1, ECO:0000313|Proteomes:UP000029284}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000256|ARBA:ARBA00006270}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFY81461.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JPKC01003657; KFY81461.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094ERU1; -.
DR   STRING; 1420913.A0A094ERU1; -.
DR   HOGENOM; CLU_024999_0_0_1; -.
DR   Proteomes; UP000029284; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd05227; AR_SDR_e; 1.
DR   CDD; cd00154; Rab; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR47979; DRAB11-RELATED; 1.
DR   PANTHER; PTHR47979:SF38; GH01619P; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   Pfam; PF00071; Ras; 2.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000029284}.
FT   DOMAIN          4..260
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
FT   REGION          430..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..451
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        463..477
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   646 AA;  69839 MW;  DD50EB93FA8A8950 CRC64;
     MTRVLLTGGS GFIAAHVLES LLTRGHSVVT TVRSQEKADK IKQAYPDLGK DKLDFAIVED
     IAQEGAFDKA VISDPPFESV IHTASPFHFN VTDTKKDLLD PAINGTIGIL KAIKKSAPTV
     KHVVITSSFA AILNGSKLPN WPEHTYTEED WNPITEEQAL TNPAEGYRAS KTFAERAAWD
     FVRDEKPNFT ISTVNPPMVF GPVVNYLNSL DSLNTSNQRI RDFAQGKAKN GLPNSGVYLW
     IDVRDLALIH VRQIEVPEAA GKRFFATAGY FSNKEIADAI RNNFPEYKDN LPAADAPGDG
     DYPNGSTESL HKYDNSRVVK TLGIKFRTIE ESVVDLVKSL KAVGLHEAKP QGPRACFSST
     RTPPDLHNPI TAPPPMSSWD YIAKLVCIGD SGTGKSSLVI RLCEGRFSPH HDVTIGVEFG
     SRIVPVGPPN YVAPPKPTLS SHPSGSSPTS ADADADAADA SPDPPGLPAP PVTNPKPKPV
     VQKHMKLSLW DTAGQETYKS VTRSYFRGAS GALLVFDISR RPTFAHVQDW LADLRAIAEA
     DIVVVLVGNK SDLAAGEENK REVTVAEAEE WAAKNGVLEY VETSAKSGEG VERAFARVAE
     RIYENIEAGK YDLYDRRSGV KGPGTGQQGR VKFGGDANKA AAGGCC
//