ID A0A094EV04_9PEZI Unreviewed; 2363 AA.
AC A0A094EV04;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 30.
DE RecName: Full=MPN domain-containing protein {ECO:0000259|PROSITE:PS50249};
GN ORFNames=V498_08840 {ECO:0000313|EMBL:KFY80273.1};
OS Pseudogymnoascus sp. VKM F-4517 (FW-2822).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420911 {ECO:0000313|EMBL:KFY80273.1, ECO:0000313|Proteomes:UP000029270};
RN [1] {ECO:0000313|EMBL:KFY80273.1, ECO:0000313|Proteomes:UP000029270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4517 (FW-2822) {ECO:0000313|Proteomes:UP000029270};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY80273.1}.
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DR EMBL; JPKA01003597; KFY80273.1; -; Genomic_DNA.
DR HOGENOM; CLU_000380_3_0_1; -.
DR Proteomes; UP000029270; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:InterPro.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:InterPro.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd08056; MPN_PRP8; 1.
DR CDD; cd13838; RNase_H_like_Prp8_IV; 1.
DR Gene3D; 1.20.80.40; -; 1.
DR Gene3D; 3.30.420.230; -; 1.
DR Gene3D; 3.90.1570.40; -; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 3.30.43.40; Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR012591; PRO8NT.
DR InterPro; IPR012592; PROCN.
DR InterPro; IPR012984; PROCT.
DR InterPro; IPR027652; PRP8.
DR InterPro; IPR021983; PRP8_domainIV.
DR InterPro; IPR043173; Prp8_domainIV_fingers.
DR InterPro; IPR043172; Prp8_domainIV_palm.
DR InterPro; IPR019581; Prp8_U5-snRNA-bd.
DR InterPro; IPR042516; Prp8_U5-snRNA-bd_sf.
DR InterPro; IPR019580; Prp8_U6-snRNA-bd.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR019582; RRM_spliceosomal_PrP8.
DR PANTHER; PTHR11140; PRE-MRNA SPLICING FACTOR PRP8; 1.
DR PANTHER; PTHR11140:SF0; PRE-MRNA-PROCESSING-SPLICING FACTOR 8; 1.
DR Pfam; PF08082; PRO8NT; 1.
DR Pfam; PF08083; PROCN; 1.
DR Pfam; PF08084; PROCT; 1.
DR Pfam; PF12134; PRP8_domainIV; 1.
DR Pfam; PF10598; RRM_4; 1.
DR Pfam; PF10597; U5_2-snRNA_bdg; 1.
DR Pfam; PF10596; U6-snRNA_bdg; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 2.
DR PROSITE; PS50249; MPN; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 2131..2262
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..38
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..70
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2363 AA; 274422 MW; E528C9F7B543B04A CRC64;
MSSIPPPPPP GWSSSAQPSQ PLGAPPGAPP PPGYRPPQDP HVAKFAQKKK DWVRSQKNRF
GEKRKGGFVE TQKADMPPEH LRKIVKDIGD VSQKKFSSDK RSYLGALKYM PHAVMKLLEN
MPMPWESARE VKVLYHVNGC LTLVNEIPRV IEPVFHAQWA SMWVCMRREK SDRRHFKRMR
FPPFDDEEPP LSWSENIEDV EPLEPIQMEL DENEDAAVYE WFYENRPLLD TPHVNGPSYK
EWNLTLPQMA TLYRLSHQLL SDLVDKNYFH MFELKSFLTA KALNVAIPGG PRFEPLYKDV
DPNDEDFGEF NAIDRIIFRA PIRTEYRVEF PFLYNSLPRS VHISNYSYPQ IVYVRAEDPS
LPAFYFDPVI NPISSRSVAP KNITVSHEDE LFGYGNNEES EEDAFVLPQE AEPFFADEEL
YTSETASAIA LWWAPYPFDR RSGRMVRAQD VPLVKQWYLE HCPQGQPVKV RVSYQKLLKT
FVLNELHKKK PKAQNKQNLM KSLKQTKFFQ QTTIDWVEAG LQVCRQGFNM LNLLIHRKNL
TYLHLDYNFN LKPVKTLTTK ERKKSRFGNA FHLMREILRL TKLIVDAQVQ YRLGNIDAFQ
LADGIMYAFN HVGQLTGMYR YKYKLMHQIR SCKDLKHLIY YRFNSGPVGK GPGCGFWAPA
WRVWLFFMRG IIPLLERWLG NLLSRQFEGR HSKGVAKTVT KQRVESHFDL ELRASVMADL
MDMMPEGIKQ NKVNTVLQHL SEAWRCWKSN IPWKVPGLPA PIENIILRYV KSKADWWISV
AHYNRERIRR GATVDKTVAK KNLGRLTRLW LKAEQERQHN YMKDGPYVSS EEAVAIYTTT
VHWLESRKFS PIPFPSVSYK HDTKILILAL ERLREAYSVK GRLNQSQREE LALIEQAYDS
PGTTLERIKR FLLTQRAFKE VGIDMNDNYS TINPVYDIEP VEKISDAYLD QYLWYQADQR
HLFPAWIKPS DSEVPPLLTY KWAQGINNLD KVWETENGEC DVMIETQLSK VYEKIDLTLL
NRLLRLIMDH NLADYITSKN NVQLTYKDMN HVNSYGMIRG LQFSAFVFQY YGLVLDLLLL
GLQRASEIAG PPQSPNDFLQ FRDRETETRH PIRLYTRYID RIWVFFRFSA DESRDLIQRF
LTEQPDPNFE NVIGYRNKKC WPRDSRMRLM RHDVNLGRAV FWDLKNRLPR SVTTIEWDDT
FASVYSRDNP NLLFSMCGFE VRILPKSRNL NDEFPVKDSV WSLVDNTSKE RTAHAFLQVT
EEDIAKFNNR IRQILMSSGS TTFTKIANKW NTSLIALFTY YREAAVSTVN LLDTIVKCET
KIQTRVKIGL NSKMPSRFPP AVFYTPKELG GLGMISGSHI LIPTSDKRWS KQTDTGVTHY
RAGMTHDEDT LIPNIFRYII PWEAEFIDSQ RVWTEYSQKR LEANQQNRRL TLEDLEDSWD
RGLPRINTLF QKDRSTLSFD KGFRARTEFK TYQLMKSNPF WWTSQRHDGK LWNLNAYRTD
VIQALGGVET ILEHTLFKAT AFPSWEGLFW EKASGFEESM KFKKLTNAQR SGLNQIPNRR
FTLWWSPTIN RANVYVGFQV QLDLTGIFLH GKIPTLKISL IQIFRAHLWQ KIHENVVMDL
CQVFDQELES LGIETVQKET IHPRKSYKMN SSCADILLFA SHKWNVTRPS ILFDTKDVIE
PTTTNKFWVD VQLRYGDYDS HDIERYTRAK YLDYTTDSMS IYPSATGLMI GIDLAYNLYS
AYGQYFPGLK TLVQQAMAKI MKANPALYVL RERIRKGLQL YASESNQEFL NSQNYSELFS
SQIQLFIDDT NVYRVTIHKT FEGNLTTKPI NGAIFIFNPR TGQLFLKIIH TSVWAGQKRL
GQLAKWKTAE EVAALIRSLP VEEQPKQLIV TRKGLLDPLE VHLLDFPNIS IRASELQLPF
QSAIKLEKLN DMILRATEPQ MVLFNLYDDW LKTISSYTAF SRLVLILRAL HVNADKTKLL
LRPDKTVITQ EHHIWPSLSD EDWIKVETQL RDLILNDYGK KNNVNTSSLT SSEVRDIILG
MEISAPSMQR QQAAEIEKQQ QEQQQLTAVT TKTQNVHGED IIVTTTSQFE QQTFASKTEW
RTRAIATSNL RTRANNIYIS SDDIKEDDHF TYIMPKNVLK RFITIADLRV QVAGYLYGSS
PPDNDQVKEI RCIVMVPQIG NTRDVQLPHQ LPQHEYLEKL EPLGIIHTIS GNEPPYMTAA
DVTQHARLMN SHDSWDKKTI TMTVSFTPGS VSLASWALTP HGYKWGAENK DLGSEQPQGF
STSMGEKCQL LLSDKIRGYF LVPENNTWNY SFMGSAFGGI EKKPVHVKID TPLPFYNDQH
RPLHFQNFAE LEDIWVDRSD NFA
//
