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Database: UniProt
Entry: A0A094FNH6_9PEZI
LinkDB: A0A094FNH6_9PEZI
Original site: A0A094FNH6_9PEZI 
ID   A0A094FNH6_9PEZI        Unreviewed;      1280 AA.
AC   A0A094FNH6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   25-APR-2018, entry version 17.
DE   RecName: Full=Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) {ECO:0000256|RuleBase:RU363018};
DE            EC=2.5.1.87 {ECO:0000256|RuleBase:RU363018};
GN   ORFNames=V498_06081 {ECO:0000313|EMBL:KFY90288.1};
OS   Pseudogymnoascus sp. VKM F-4517 (FW-2822).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420911 {ECO:0000313|EMBL:KFY90288.1, ECO:0000313|Proteomes:UP000029270};
RN   [1] {ECO:0000313|EMBL:KFY90288.1, ECO:0000313|Proteomes:UP000029270}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4517 (FW-2822) {ECO:0000313|Proteomes:UP000029270};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A.,
RA   Gerasimov E.S., Kochkina G.A., Ivanushkina N.E., Vasilenko O.V.,
RA   Kondrashov A.S., Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence
RT   of horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adds multiple copies of isopentenyl pyrophosphate (IPP)
CC       to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl
CC       diphosphate (Dedol-PP), a precursor of dolichol which is utilized
CC       as a sugar carrier in protein glycosylation in the endoplasmic
CC       reticulum (ER). {ECO:0000256|RuleBase:RU363018}.
CC   -!- CATALYTIC ACTIVITY: (2E,6E)-farnesyl diphosphate + n isopentenyl
CC       diphosphate = n diphosphate + ditrans,polycis-polyprenyl
CC       diphosphate (n = 10-55). {ECO:0000256|RuleBase:RU363018}.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC       {ECO:0000256|RuleBase:RU363018}.
CC   -!- SIMILARITY: Belongs to the UPP synthase family.
CC       {ECO:0000256|RuleBase:RU363018}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU363018}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KFY90288.1}.
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DR   EMBL; JPKA01001467; KFY90288.1; -; Genomic_DNA.
DR   EnsemblFungi; KFY90288; KFY90288; V498_06081.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000029270; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR   CDD; cd00475; Cis_IPPS; 1.
DR   Gene3D; 3.40.1180.10; -; 2.
DR   HAMAP; MF_01139; ISPT; 1.
DR   InterPro; IPR001441; UPP_synth-like.
DR   InterPro; IPR018520; UPP_synth-like_CS.
DR   InterPro; IPR036424; UPP_synth-like_sf.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01255; Prenyltransf; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   SUPFAM; SSF64005; SSF64005; 2.
DR   TIGRFAMs; TIGR00055; uppS; 1.
DR   PROSITE; PS01066; UPP_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029270};
KW   Membrane {ECO:0000256|RuleBase:RU363018};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029270};
KW   Transferase {ECO:0000256|RuleBase:RU363018};
KW   Transmembrane {ECO:0000256|RuleBase:RU363018};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM    832    857       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM    877    896       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM    954    972       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM    984   1007       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM   1063   1082       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM   1180   1199       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   TRANSMEM   1211   1232       Helical. {ECO:0000256|RuleBase:RU363018}.
FT   COILED      509    536       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1280 AA;  145539 MW;  1F0D5DB90C0A01B3 CRC64;
     MKLLASLCEA EPSMRWGESR NVGGATVDDV APRPRRPATI RQRLQDPSAN MTSMHLNQLR
     KWVYSSPPVE YGMNQLRELL IGAVSQGPVP QHIAFVMDGN RRFARSHKIE TAEGHNLGFE
     SLAKILEVCY KLGVKVITVY AFSIENFKRS KYEVDALMDL FKVKLAQISQ HGELLDQYGA
     SVRILGQRDL IRPDILEACN NAVEVTRGNG DAILNICFPY TSRDEITTAI RSTVDELSTP
     LPTPKRPFSE RRIAQKLRSR NLTSTSSSPP RQASPTRVEV PGAELDDSIS SSATLHPDSV
     TSSDVPNPDE PSYPDPESIT AATVESHLFT AGNPPLDLLI RTSGVNRLSD FMLWQCHEDT
     QLRFLDCYWP EFSLRHFLPV LIEWQWQRKY GDDKEGGAVK SRPKFFAIMA PAKDTMFRSV
     DMSMVQLYVA NEIGREVINA LGEIGQIQFR DLNSETSAFQ RTFTQEIRRL DNVERQLRYF
     HAQMEKAGIP LRKLDLDIES LAAPSTSEID ELSDRSQSLE QRVASLNDSY ETLKKREVEL
     IEWRWVLKEA GGFFDRAHGN VDELRTSIDQ DDDAPLLQDV EQHPQNGDAG ERTLSIMNIG
     FVSGVIPRER VAAFERILWR TLRGNLYMNQ SEIPETLVDP TNNESVDKNV FVIFAHGKEI
     IAKIRKISES LGADLYAVDE NSDLRRDQIH EVNTRLSDLG SVLRNTKQTL DAELTQIARS
     LAAWIVIIKK EKAVYETLNL LSYDHARKTL IAEAWCPSNS LPQIKAALQD VNNRAGLTVP
     SIINEIRTNK TPPTLQKTNR FTEGFQTIIN AYGTSKYHEV NPGLPTIVTF PFLFAVMFGD
     LGHGFIMFCA AAAMIYWEKP LKKVRDELFT MAYYGRYIML MMGIFSMYTG LIYNDIFSRS
     MSLFSSAWEW PTDFKQGDTV VAKLTTQRYP FGLDWMWHGA ENELLFANSY KMKLSILMGW
     CHMTYSLCLS YINARRFKSP IDIWGNFIPG MIFFQSIFGY LVFTIVYKWS TDWYPMAPEG
     WPIDVQPPNH RNPPGLLNML IYMFLQPNKI DVPLYGDGTY QKIIQNFLVV IAIIQVPILL
     FLKPFYLRWE NNQARAKGYR GIGETSRISA LDGDDDDRHS FGRASIASET EGVDMITQGI
     DNDGEGHEEF EFGEVMIHQV IHTIEFCLNC VSHTASYLRL WALSLAHQQL SLVLWSMTLN
     NGLNSTGISG VLTLVVTFYM WFFLSVCVLV VMEGTSAMLH SLRLHWVEAM SKHFMGDGIA
     FEPFSFRQML EEDEEVKEFS
//
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