ID A0A094FSP3_9PEZI Unreviewed; 1614 AA.
AC A0A094FSP3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 28-JUN-2023, entry version 32.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=V496_04495 {ECO:0000313|EMBL:KFY62637.1};
OS Pseudogymnoascus sp. VKM F-4515 (FW-2607).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420909 {ECO:0000313|EMBL:KFY62637.1, ECO:0000313|Proteomes:UP000029302};
RN [1] {ECO:0000313|EMBL:KFY62637.1, ECO:0000313|Proteomes:UP000029302}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4515 (FW-2607) {ECO:0000313|Proteomes:UP000029302};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY62637.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPJY01000744; KFY62637.1; -; Genomic_DNA.
DR HOGENOM; CLU_003209_0_0_1; -.
DR OrthoDB; 1786197at2759; -.
DR Proteomes; UP000029302; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd12148; fungal_TF_MHR; 1.
DR CDD; cd09019; galactose_mutarotase_like; 1.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR047215; Galactose_mutarotase-like.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR PANTHER; PTHR43791:SF65; MFS DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR43791; PERMEASE-RELATED; 1.
DR Pfam; PF01263; Aldose_epim; 1.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 194..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..534
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1614 AA; 178960 MW; AED4D930222B3221 CRC64;
MAVDSYPDEK STIPSHTKVN NTNSSSVSPS ITDDEIDGGG KEHKNANYGS TEQHIFSDSA
NLGYWSRVYE TAKYEGRHRF DSLLQWDASE EKGLVRKLDL RIMLWVWIVF SSLDLNRRNI
NRALSDNLLD DLGMNTNDFN NGQTIYFFTF LAAELPGGLL SKKIGPDIMT PFAVVTWGTI
SACQCLIKNR TGYYITRAVL GFSQGGFIPE MILYLSYFYK SNELPVRISF FYTAIPLTQI
IGSLLAGGIM AMRGIAGLAG WRWLFLIEGL MSIVVGLITF LVMPASITET SRILRGKASW
LNGKDGWFTP REEGILVNRI LRDDPTKGDM NNRQHVDLKG LWKALKDVDL WPIYTLGVLA
FLPYQPTASY LSLTLKNLGY SVFEANVLAI PGFILFFVNV LVVVWVSEKF NERMLISAWS
NIWMFPFFVG LVTIPVSASP WVRYALLTGV NGIPYTHAIL VGMISRNANS VATRAVSTAL
YNMSYQFGSI AAANIYRDSD KPYYYTGNKV LLGLCSANIA IFVLAKLYYI KRNEAKERGW
NKLKSLLSVG YQLIKGGESR ASGVKIVKLN AQELLHVNAV PRPGCGYVNA LEDRVGALES
LLHELNPAGN SDHGANNDAV NFGFESPTPA YQDTGSVASP SSDGSHCGGM VAPSQDRRTN
YPGPSSLRNS KVLKSAAEHP SIHFPTPYKP AHVDVQTEVD GHVIAECVAL FFRWHYPQCM
FVDRDKFLLG FLNHSYTSKN SSRSLEFSIC ALGALLSPEK PIRDLAGSFY DAAVRSLESG
GLLEPQESSI QTLTLCSFYQ IGQGNFTQAW MLSGIAFRMC EELNDSSHGN PSTPRDIDSR
RRTFASCYKS DKMISQVLGR LPVIAKQTQS TGCKEVERTH SIWYHWLEQN GLLDLEEPET
LTDSTSPAEK QMELSKIIHD MLLPRDFSSK GSAQQPTTRR WTEVAISELN TRLWGWHSTI
PGELRWNRWG SSSDAVIPSI AALHMLYHIS QISLNLPFLL DSQPSWESSQ APNLPKLVSD
AVDICGASVD IVISILRRFR SQYTLTKVPL NLVHGGIIAA DAILAMMDFC DGERRGSLVK
DLYVLDDALL EMSYSWNIAT TARTGLKNLL AEKTSSQATI TGLSAPPKQP TTFDLEAFAY
QPFTPLSLGS EDGIQLSGLA FPEMFSAGVS DASSSDMWDL NFPEKGFSFD DSTFLRLSFL
PTLRSAVFQT SQFAFKMLSR NLLFLASLLA PAAATGLGPD ADGKYTISSK GLRAQFVAYG
ASISNLFLKD AEGRERDIVL GFDNATYYAE DPRHSHWGSV PGRYANRIKN STFDIDGVTY
NILPNEHPTP EHPDGVNTLH GGPNGWDYRE FNVSAQTSNS ITFTITDEDG NQGFPGEVIS
YITYTLNDMT WDITIVAHST TKKTPIMLSS HTYWNLDGFQ NPETGTILNH SLWLPHSGQR
IGVDSILIPD GTILPNKPGS VNDFWSAPKQ LGANLTNPDL VGNCGEGCTG YDNCYLVNRG
QDGPYDWRSK PVAVLGSPWS GIQIDVFSEQ EAFQIYTCND YNSSLPVKST QGTDVRRSVP
AYGCIVMEVQ DWIDAINQPE WQRSKKQIYG PSDDPYVLRA KYVFSAEKKK HHGL
//
