ID A0A094FVX9_9PEZI Unreviewed; 2980 AA.
AC A0A094FVX9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFY95024.1};
GN ORFNames=V500_02969 {ECO:0000313|EMBL:KFY95024.1};
OS Pseudogymnoascus sp. VKM F-4518 (FW-2643).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420913 {ECO:0000313|EMBL:KFY95024.1, ECO:0000313|Proteomes:UP000029284};
RN [1] {ECO:0000313|EMBL:KFY95024.1, ECO:0000313|Proteomes:UP000029284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4518 (FW-2643) {ECO:0000313|Proteomes:UP000029284};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY95024.1}.
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DR EMBL; JPKC01000921; KFY95024.1; -; Genomic_DNA.
DR STRING; 1420913.A0A094FVX9; -.
DR HOGENOM; CLU_000022_37_7_1; -.
DR Proteomes; UP000029284; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd19532; C_PKS-NRPS; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF20; HYBRID PKS-NRPS SYNTHETASE APDA; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000029284};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..444
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2392..2467
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2980 AA; 328447 MW; ED3D037A33CEB359 CRC64;
MVYVNAQANE PIAVIGSGCR FPGSASSPSK LWELLKQPRD LLSKIPKERF DVDAFYHPDG
THHGRTNARY AYLLDQDPYE FDASFFNLPA NEVSTIDPQH RLMLETVYDG ITTAGLKMED
LRGSSTAVYV GMMHRDFLDN QNYDLDAMNM YAATGTSASI LSNRVSYFFD WHGPSMTIDT
ACSSSLVAVH HAIQQLRTGS SKVAIAAGAN LILGPFSLIV TSKLNMLSPT GRSRMWDAGA
DGYAKGEGVA AVVLKTLSQA LKDGDSIECI IRESGISQDG RTPGITMPSH TAQEALIRDV
YSRAGLDLTK PENRPQYFEA HGTGTAAGDP QEAQAISSAF FGERERGTDE EPLYVGSIKT
IIGHTEGTAG IAGLMKASLA IQHGVIPPNM LFEKLSDQVA PFYRDLHVVT KNQSWPKLQY
DQPRRVSVNS FGFGGTNAHI IVESSPTLRD TTITGSTPCL APIALSANSE SSLKAAIEDL
ADYLKTEPDT RIHDLVWTLL RNRSDHSVRY TTPSGSVAAV REALIHDAAL IQGKQSIAIM
SEARTRPQVL GIFTGQGAQW PAMGKVLLST FAKAREIVLE LDHSLQTLPQ AFRPTWKLID
QLQLEGDDSM VHDATFSQPI CCAIQILLTK LLFAAGIQFK VVVGHSSGEI ACAYAAGFIS
SSQAVRIAYL RGLTSQLAKS PSGVEGAMMA VGTTFEDAQE LCALETFEGR LKVAASNGPD
SVTLSGDKDA ILEAQEILND ESRFNRLLKV DKAYHSHHMA PCAEPYIAAL KACGCDTSDL
DIEPSATWIS SVFEGRVMKP DDLRAEYWKD NLLSPVLFQD AVEQAIIKHN PIDVCLEVGA
HPALKDPTLK TVENCGGFSL PYTGFMQRKK NDLDAFSAGL GYLWSHFGTP VLDLDRLYNE
LSIDTGTKSL SKDLPCYPWD HSRKHKKESR RLKAFLGAQK PHLLLGKVLA HSTPSMILWQ
NHIRQRDIKW LDGHSLQGQT VFPGAGYVVM AMEAALHEAG DREVQLLEVL NLVIDKAVTF
EDENSLIELN LSLMVNTSEV TDTSISYTFV INSCLAKETS LSSSATGTIV VVFGQGSLET
LPVAQTEPPH MNKVSVDRFY NMLDEIGYGY TKQFRGVSSL RRGDSKACGT IDFHRLEDNH
RQLVMHPASL DVAFQTFIGA YTSPGDKRLR NLLVPTGIDR IVLNPWATGQ IHSLSRNVNF
VSTSTAGAGN GVAGDIEVFD PDTRATILQI EGLSFKPFSP PSAADDHQMF AKWTWSQLNP
DAVLDDSRYH SSETDKAATE MIERITYWYI KSFLNSLTTE DRGRAAFHQT KQIQWCEYII
AETKSGHNIW YDIAWEADTP DDIERFIRDW FYHPFIRLIQ RVGENMLDVI RDNRNPFDLM
DHDGLLTEFY GSTISYGHSY HYFQKLCAQI NHRYQNMDVL EIGAGTGGAS RYFLNSEQVS
FNNYTFTDIS NAFFEQAAKE FAEHADKMEF RPLDIRRDPV EQEYKPNSYD LVIASNVLHA
TPRLEETLAN VRKLLKPGGQ LVIIEVTHRE HARIGFIFGL FADWWAGHDE GRVHEPFVTY
EKWDELFRRT GFSGIDSRTL DPDSTIFPNG VFSTHAVNDL TKILDSPLTA PIKESYPPLV
VIGGASSKTA LLLEKLRSTV PQRSLLTVNR IRDVIDAGVE PRSTFIVLSE LDEETFTGLD
NDQFESLQAI FDRASHVLWV TESAWVNHPQ QGMTIGLLRT LRLEYLNIQL QVLDVDYAES
LTSEVLIETV QRLEDGSNWQ ENGILWTQEP ELYLHKDQLV VARLKPDVAK NNRLNSNRRP
VTASFDPCQD ELALVNEEGV DFFRCLEERH VPDTIADHLV RVQVTHSLAK AVRVGKLGIF
NLIQGYITAS GEAVVTLSES HASFIQASND QLVRLESQQA DATCVLPALL ADLVAQTLLA
DAAPGTTVLV FDPPNYFIDS LVRQGVAAEV RVVIATVNPP VDGHNTQWIQ LHPRETQRQL
LKKIPANVSV FYNLATTEHI KELGRRLSAN LPSSCHVAFL TSLIHGSAAP VSENCSRDAL
VALQGAVTRL GEVKVKDTKS TLTPSQLLSV EGASRFDSII QWQAEPKITA RVRSIETGRL
FVDDKTYLLV GLSGDLGRSI ARFMIEGGAR HIVLSSRSPK IDPQWIEDMA AAGGSIMVLP
MDVSNEASVD SGLATIRASM PPIAGVAFGP LVLQDVMFNN MDLSLMEMVL APKVTGARLL
NERLSDPSSP LDFFVMFSSF VMVSGNPGQA AYSAANAFTH ALAQQRRSRG MAGSTIDIGA
VYGVGFIARA GREEEYDVVR FMFDEVNEWE LHALFAEAVV AGRAPGTDQV ELVTGMPYVD
PADRDQIPYF DDPRLAYYKL SDGRNKGHEL VSAKGSVQER LLKAETMDEV CAIILEGVSA
KIRGALQVAA SDDLNLTSPL VDQGVDSLSA VTIGTWFSRN LSVDVPLLKI LGGASVSDLV
EESISRILPG AIPLAYDGSA NEILKDEAPV AVEVEAMGLA SNSGRYDDLS LPSDYMNVPT
PISLLSSPSD QKAEGVERIA PLSIAQEYCW KQQQLGLDPS TFNSTIGMFM QGALDLNRLS
WAFNQALQRH DAFRTSFVTN PADKSRPLQS VMKSPAVGFE TIKVADRAAA ERGFKDLERY
EYNFSEGMTL KVVNYSWSST DHLLVFAYHR LVGDGWTTEH LFVEAGQLYN GVQLDPPPSY
ADFAVRQRKD LVSGAAENDL SYWSTLFKTL PVRLPMLDVP GKRISASPTW SEHETSARLN
PMIAVRIKDR SRKHKTTPMH FYLAAFHVLL ARLTTSTDVA IGVADTNRST LTDQATMGFF
ASLLPVRLRY SPDDIFAEAL IAVKDEIRAA LLHSAVPYGA ILEHLGLPNP SAADPESQAP
LFQAVFDYKQ GQAETGSIGR ANIVESRTSR AGSPYDIILE MSDDSNKDPL IILKLQSERY
ASGDAEVVMD AYLSILSIFS RNPALRVEDG RLDQGARAKP
//
