ID   A0A094GBL2_9PEZI        Unreviewed;       505 AA.
AC   A0A094GBL2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   22-FEB-2023, entry version 30.
DE   RecName: Full=Hsp90 chaperone protein kinase-targeting subunit {ECO:0000256|ARBA:ARBA00031396};
GN   ORFNames=V498_00129 {ECO:0000313|EMBL:KFZ00410.1};
OS   Pseudogymnoascus sp. VKM F-4517 (FW-2822).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420911 {ECO:0000313|EMBL:KFZ00410.1, ECO:0000313|Proteomes:UP000029270};
RN   [1] {ECO:0000313|EMBL:KFZ00410.1, ECO:0000313|Proteomes:UP000029270}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4517 (FW-2822) {ECO:0000313|Proteomes:UP000029270};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the CDC37 family.
CC       {ECO:0000256|ARBA:ARBA00006222}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ00410.1}.
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DR   EMBL; JPKA01000011; KFZ00410.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094GBL2; -.
DR   HOGENOM; CLU_033261_0_0_1; -.
DR   Proteomes; UP000029270; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   Gene3D; 1.20.58.610; Cdc37, Hsp90 binding domain; 1.
DR   InterPro; IPR004918; Cdc37.
DR   InterPro; IPR013873; Cdc37_C.
DR   InterPro; IPR013874; Cdc37_Hsp90-bd.
DR   InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR   InterPro; IPR013855; Cdc37_N_dom.
DR   PANTHER; PTHR12800; CDC37-RELATED; 1.
DR   PANTHER; PTHR12800:SF4; HSP90 CO-CHAPERONE CDC37; 1.
DR   Pfam; PF08564; CDC37_C; 1.
DR   Pfam; PF08565; CDC37_M; 1.
DR   Pfam; PF03234; CDC37_N; 1.
DR   SMART; SM01069; CDC37_C; 1.
DR   SMART; SM01070; CDC37_M; 1.
DR   SMART; SM01071; CDC37_N; 1.
DR   SUPFAM; SSF101391; Hsp90 co-chaperone CDC37; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          2..195
FT                   /note="Cdc37 N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01071"
FT   DOMAIN          198..379
FT                   /note="Cdc37 Hsp90 binding"
FT                   /evidence="ECO:0000259|SMART:SM01070"
FT   DOMAIN          396..503
FT                   /note="Cdc37 C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01069"
FT   REGION          97..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          147..181
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        190..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  56492 MW;  D9C2ADDB41233A79 CRC64;
     MPLDYSKWDA LELSDDSDIE VHPNVDKRSF IRAKQNQIHQ ERDHRKLQIV TFKYERIIND
     GFLKRIEGLL KALESHKSEA ESRGADEIIF QSLMESADPE NDQPPARPEG VHTDEKELPS
     YSKMIATLID QVKASVAEKK VPDSEKLLAY LEEVKQHKAK VDDLQRQLNE KLSELELTDS
     KKITSASIHT GFDSSSVNKS APPPPSSTEK SKSKVVEVLN PQALDKTPSR DSGADADVDE
     PKATADGESS DDEDHHATEI GKKFARIKMG DYRACVNFIS EHPEVIAERE TDGLLIMAFD
     AELAGKSSVA QQCVHQALLL QYCRTLGRDG VGLFFKRITT PGHQAQKVFT DDVKDTYLRI
     HKRAKEILKE REKEEEAGGV EQIQLHAVEP GTEIKIFVPP KELLESADEE ERRSREIFEA
     FPPGLQRALE SASLDEVNKV LGKMSVDEAE EVVGQLSEGG MLSLGEQIID TTTAEGQAEL
     KRLEDEEKES KAEQEKLDKY AGDPE
//