ID A0A094GIU9_9PEZI Unreviewed; 809 AA.
AC A0A094GIU9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN ORFNames=V498_02974 {ECO:0000313|EMBL:KFY96015.1};
OS Pseudogymnoascus sp. VKM F-4517 (FW-2822).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420911 {ECO:0000313|EMBL:KFY96015.1, ECO:0000313|Proteomes:UP000029270};
RN [1] {ECO:0000313|EMBL:KFY96015.1, ECO:0000313|Proteomes:UP000029270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4517 (FW-2822) {ECO:0000313|Proteomes:UP000029270};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY96015.1}.
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DR EMBL; JPKA01000488; KFY96015.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094GIU9; -.
DR HOGENOM; CLU_002738_3_0_1; -.
DR Proteomes; UP000029270; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 2.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF82; PHOSPHOINOSITIDE PHOSPHOLIPASE C; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133}.
FT DOMAIN 550..663
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT REGION 86..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 88649 MW; D240D19B08EC0AC8 CRC64;
MVLVSTLLCA GRQTQGWASS YSQTGAPIND VGRVQAVPAI HSARGWGTEA EFSSRDLYLR
GDGRQHWQRH QPRPPLPIAA TISPTFAQQT HGTPQSQRRA QAPPLLPLPR LNDYPHGTNA
PPHGALAAYA ALPLARRASA PAENLHHPVR GLAGHDIPLS EDVEEYSYED WLALLWMKGG
LEAVGALTGS KDLGKPISSY YISSSHNTYL SGNQLMSKST TDAYKNVLIR GCRCIEIDVH
NGEPVSTSSR RPHITGTTPS DLAVSAIQAK KKYKRKYKTE YKAKLGALKG KIPWSRSDDK
KEKAATAVTD NVEPIHLLGH KKTVSNVPSI NREKTSDSDS SSSSSDDDYD LADGSRSRSS
SVLKGEPVVL HAWTLTRAVG FREVCRAVRE SAFQTTNLPL IVSLQVGCDL DQQEVMVQIM
KEEWEGVLVD TAHPTCHPEE RLPRLDELLN KILIKVKRSS EVPPSEPPSP NVSMATSSNP
ITPLSASTTI SSRPSTLTPT ATISTPLSPT TSNDNLDALS ESSRSRSPSL SRSRSRSPAP
KTKARMHPSL SALGIYTHSS HFSSLTASSA STPSHIYSLS EGDILELFAA SPNALLAHNR
SYMMRAYPAG HRIDSSNPDP SVFWRKGIQM AALNWQVWDE GTMLNEAMFA DSDGWVLKPP
GMREGGELVE LDAQKVDGKL LDLRIRVFAA QRILGEKELR ARVKVEVHAE RAGEKAGEEW
KRHTETKRGA SVDWEGERLD FLGAGPGVVE ELSFVRFRIE DDGFTDTLAA WACVRLDRLQ
NGYRFLKLRD AKGAATDGLL FIGVEKIER
//
