ID A0A094GRR0_9PEZI Unreviewed; 2745 AA.
AC A0A094GRR0;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KFY74597.1};
GN ORFNames=V499_05344 {ECO:0000313|EMBL:KFY74597.1};
OS Pseudogymnoascus sp. VKM F-103.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420912 {ECO:0000313|EMBL:KFY74597.1, ECO:0000313|Proteomes:UP000029295};
RN [1] {ECO:0000313|EMBL:KFY74597.1, ECO:0000313|Proteomes:UP000029295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-103 {ECO:0000313|EMBL:KFY74597.1,
RC ECO:0000313|Proteomes:UP000029295};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY74597.1}.
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DR EMBL; JPKB01000852; KFY74597.1; -; Genomic_DNA.
DR HOGENOM; CLU_000022_31_0_1; -.
DR Proteomes; UP000029295; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 119..546
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2653..2730
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 48..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2745 AA; 292667 MW; CFD765BD5E13D797 CRC64;
MPALASAHPS LRALALDVEA ALASLSQRLD SRLDLLEARS LGGLASTDTS AFTSSPRPIH
RRPVLPYAPD TPPLSAPLRE ETLLEDEQQR RVAEVLTPGS SVNEGAGGSV QEGEGEDKSM
PIAIVGMGCR FPQEATSPEK LWEMLYNKRH ARTEVPKDRF NVESFYHPDA DRSGSMNLKG
GHYLKEDIAT FDARFFSISP AEAKSMDPMQ RILLEVVYEA MENAGITLAD LDGSDTGCYV
GCFTDDYDGL LKRDMELSPK YHSVGIVPAI LSNRISFCFN LKGPSLTVDT ACSSSLVAVH
LACQSLRAGE SRVAIVGATN ALINPEIHVG MSNMHFLSPD STCFTFDERA NGYARGEGMA
ALILKPLDAA IRDGDTIRAV IRGTASNQDG KTAGMTLPSK EAQAELIQTA YEQAGCDPAA
TGYFEAHGTG TAAGDPIEAS AIGATLGKFR GPGEEGKLFV GSVKTNIGHL EGASGLAGLI
KAVLSLERGV VLPNLWFENG NPAIDFEGWR IKVPTEPTAW PTEGLRRASI NSFGFGGTNC
HAIIDDAYHY LQSRGLKGNH TTSPRSLLGE GMQRPMLLGQ GRKFEEIVEE DAILSSASVL
ARPRIFKVSA NEEKLAVTLA NSFAEHLATI PTDTTDTAYL DNLAYTLHTR RTTLPWTVAV
VASSIAELAT KLEAPGLKPI RRAAETPKLG FVFTGQGAQW AGMGRELLAY PVFKDVVMKA
DGILASLGAR WSLLTELSKP ESESRINEAA ISQPLCTALQ IALADLLSSW GVHPARVVGH
SSGEIAAAYA IGALSLRGAL QVAYFRGVHS SRVSSLGLRG AMMAVGLDET AARGYVESVD
AAFGRVVVAC INSPRSVTVS GDESAIEALK RRLDADGVFA RKLMVDTAYH SHHMHSIAAA
YRADLADLAV TPPGQRWPIE MISSVTSRSA ADEALDADYW VRNMVSPVQF SSALAHLCTP
EPKGKKKGQR RARGGAVNIL VELGPHAALG GPVKQILTAS TSLSKAGITY LPALLRNKDG
AETMLALAAS LSASGHGADV HTANFPSPLP QPLATLPDLP SYAWNHSTRY WSESRLSLDY
RLRPFPRTDV LGAQSTDWNP TEPMWRNFVR LSELPWLKHH QVQDTVIYPA AGYVCMALEA
AAQVLSVTAL PPGRMVRGFT VRDLAISRAL VVPQSEEGVE TVFSMRPLPD STTVSSAAWR
EFRVFSYGEG GWAEHCRGVV GVDFAPASAA VAAATGHAPV SIAEMVGADE FEEGERAARA
EMEKAVRVCG RKGDVGGMYD ALAAGGLWYG PSFRVITSVA TGGGMAVGRV AVPDTRSTMP
MEFEYPSLVH PATLDGFIQM IIPALSQGDL GSAVHEPFVP TFIEELTFAS TIASQAGYEF
RACAKAAFKG VREAVAGITV FDPLGGEAVV KIKGMKCTAI SGGGPVDVVR KHCGTAVWEP
DVDLLGDLQM LRVLRGAAVR AASPGVAGRE DVEVVAWWFC DAALRDVKDV EVSSERRELY
EFLLHQREVV RVGRAEYQTP LWEALEDFAT QERVHNLIAD FSTSGDAEAR LLVRMGMALP
GVLRGEIDPD VFRQESGVVS DYFATAMGVP HTYAALQRYL TMLAHKYPDL EYLELGAGTG
DATRHVLDAL DGCAKYRYPK VKAYTYSDPS DATFAATTKA FEKWGSLFET RVLDIAGDIG
AQGFAGRQFD VVIAANSLGD EAVDVEVALA NVRALLKPGG KLILLEATHL HLSAAVILTR
PTPPLQEHQW EDVLSRHGFG ALEASVPDVL DSRAHVTSVM VASVLKPDAN VATLGLPLSL
HVILVAPYGG GAAAAELLDS TCSALGGHGI GVEIVSFTGL ARTELTGKIV ICLAELDASV
LAEVLPADFA QLQRLTSEPV GLLWITRGSI AGRSSKPELS IFQGLARSLR AEQEGFPCVT
VDLDADYRLP ADQVVDLLFG VFRQTFVRGQ AAAVNDREFA ERNGILHVKR MVEDDAFNKY
IATRTGAAAL KPRAEKLVQP GRPLKLTLDG VGSLDSFYFS DDPTVGATVP IAKGEVEISV
RAVGLNFRDI LIAMGEMSDN YLGNECAGVV TQVGEGVTHV SVGDRVAVWC LGCFATLMRN
PADTVMRIPD DMDFVTAAGF PIIYVTAYYA LVHLARMQAG ESVLIHAAAG GVGQAAIQIA
QRLGAEVYVT VGTGEKKAHI MSLFGIPAER IFSSRDVSFE AGVKRVTDGR GVDVVLNSLA
GESLRASWRC VAPFGRFVEL GKRDIEAGGR LDMGPFVRNV VFASVDITAM LRLNRRLGSS
MFREAMGMGM EIRRELGEMN GEEGGANPVR TWGFGEVGEA FRHMQAGRHV GKIVVVPGEA
DVVQVMPQPL KGAKFHADAS YLLAGGLGGI GRSLSMWMVA NGARNLIFVS RSGVSNDAAR
ELVSTLMGKG VRVEVIECDI ADEVRLFDSL NTSLRSMPPI RGVIQGAMVL RDQIFANMPY
ETFVSALRPK VQGSWSLHQA TLDQPLDFFV LLSSASSFLG NAGQGNYVAA CTYQVALAQH
RLGLGLPATA IDIGKVASVG VVAESKDSTI EENLIRIGLK DIQEAELHAI IELAMLPNAV
GVTNGHLITG AHTSLDPGAD IADLPFWSRD PVFSHLDALR PHLARAADGS GGASSAGRAS
LKTLLGAAPS KSAAVATVLE ALLAKLARAL AMPVAEIDAT RSTAAYGIDS LLAVDIRNWI
FREAGSDVAV FEVLQAGSVG GLAGRVVEGS AFLGAAASKA GSGDE
//
