ID A0A094GVZ4_9PEZI Unreviewed; 723 AA.
AC A0A094GVZ4;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=V499_04047 {ECO:0000313|EMBL:KFY76117.1};
OS Pseudogymnoascus sp. VKM F-103.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420912 {ECO:0000313|EMBL:KFY76117.1, ECO:0000313|Proteomes:UP000029295};
RN [1] {ECO:0000313|EMBL:KFY76117.1, ECO:0000313|Proteomes:UP000029295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-103 {ECO:0000313|EMBL:KFY76117.1,
RC ECO:0000313|Proteomes:UP000029295};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY76117.1}.
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DR EMBL; JPKB01000604; KFY76117.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094GVZ4; -.
DR HOGENOM; CLU_009058_1_0_1; -.
DR Proteomes; UP000029295; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 345..459
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 723 AA; 79954 MW; 58745C773358695C CRC64;
MSLFGTSPDE SGAASTPAKS RQTLFDDPSP ANGSQSSLFA DDDSTPGGSP WGMPTPKKAS
KGEVISTLLS GGDAPDSYVD VFESVQSKEF GQSGTVDVAG MTRVMNAAKL GADQQTRVMN
TIAPAGNTLR RNEFNVFLAL VGLAQEGDDI TLDGVDERRK KLPQPDLHNL STAPEGLPDT
SELASKPPQR PATPPTKSIP TPKSRETRPR RESLIEDDPW GSPALHKGHN HGVPQPAPAP
RHVESTATRT NGSFEPSERT TSNFTTESVI ESTNGSRESA RESRPAPNSL WYSYDGNSPN
SYGSGLPTGL EQNAFAGGLG DDPHRPPVNQ HRAIGSGGLT GNGVEENILV TLLPEKEGVF
LFQHHNYQVH SPRRGSKVVR RYSDFVWLLD CLHKRYPFRR LPLLPPKRVG VNGSYLAADS
TFIEKRRRGL VRFVNALVKH PVLNQEQLVV MLLTVPTELA VWRKQATISV QEEFTGKALL
PGLEDSLPPT LNELFETTRS GVRKSAEVYI NLCTLMDRLA KRNEGLAADH GRLSTSLMSL
TDASHATYAI DTNDVPLLNE GLLTTAKHVT DSQSLLQDEA RAWDEGVLED LKKQRDALVS
MREMFDRRER YDKDNIPQLE KRIKSNEEKL ANLRSRPEGV KPGDVERTTE SILKDKESIV
AQHARGVFVK ECLRDELTYF QDSQYQVSRW NQDWAQERVK YSELQADNWR QLNDQLESMP
IGG
//
