ID A0A094H5U8_9PEZI Unreviewed; 850 AA.
AC A0A094H5U8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 26.
DE RecName: Full=SET domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V499_01392 {ECO:0000313|EMBL:KFY79637.1};
OS Pseudogymnoascus sp. VKM F-103.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420912 {ECO:0000313|EMBL:KFY79637.1, ECO:0000313|Proteomes:UP000029295};
RN [1] {ECO:0000313|EMBL:KFY79637.1, ECO:0000313|Proteomes:UP000029295}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-103 {ECO:0000313|EMBL:KFY79637.1,
RC ECO:0000313|Proteomes:UP000029295};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY79637.1}.
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DR EMBL; JPKB01000181; KFY79637.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094H5U8; -.
DR HOGENOM; CLU_335591_0_0_1; -.
DR Proteomes; UP000029295; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 511..620
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 630..748
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 361..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 850 AA; 95476 MW; 5E7F5B914A6090E3 CRC64;
MPLTTGEREI IEIPDSPTAH PQFIEISDDE VEVIELLDYQ AKQIKPPRIP PIQPAYVPKA
DGNPESMKSE LADLYTPHDA PMVSLGMAMH IQSSSSDQGH PAGEESCYDV LDRGLGEISR
EMEKDQSSMT RHTLEVQSQF QAQPKFTATE NYMASMQSME ALQQGGTCTS PIAIIHHVAK
KTRPQTFLQG KSIQTPERAV PTYNYYVEID RSRLANNTRL PPEPFVINKN SNSKKEVEAA
LRKSMISCAK LAKHSRGREK LSSIGVYLPQ IRSAYQECRN YLEKEGLYET FGHKDANHPS
YHVEKAFGIP LGSFFDLETH VAKPQKSPTV SLDPLAKTLE RYSRESCLIC SAHQCHIHGR
FDENDSDVSE SDSSDTTDEE NPSNRSSAMY QPYSMPHTRT RTYYREGNSI ENESEGDSDC
SEQRRLYHCS AACHLNPSNE ELGNEGNWTE DDHASMQELA ASMRTRKNMR ASCLIAPMLG
KQCSEVHRHL KKLSNRRIEL DDMVPGEGRR SKKFDWRDLK VEYMHEKRSQ PRPCHHPGQN
CFVAGEKCTC VSNGICCDKF CTCPQSCDAR YHGCTCTGPC PPKKCTCRLL NRECDPDLCH
KCSVAESVRT QGPISNTKCH NCEIQRGEGK KVLVGESSIE GIGNGLYLAE PVQTGDFIAE
YVGEIIDNAE VERRDDFQKR IGNSYIFNLN AEVAIDSMWF GNATRFINHS EVGKNCQAKV
LLVNSEHRIG FYATESLDAG EELFFDYGKE FKRIEKLKDG VGSSNAERKS AKQQGTEPQV
SPIKNTKGGT GDGADEDDER DDIFEDFPDW LGTATKGNRA RDDDEDYIEP GSRQGPKRAR
PALRNTRGRR
//
