ID A0A094HB57_9PEZI Unreviewed; 2703 AA.
AC A0A094HB57;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=V502_07005 {ECO:0000313|EMBL:KFZ12615.1};
OS Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ12615.1, ECO:0000313|Proteomes:UP000029308};
RN [1] {ECO:0000313|EMBL:KFZ12615.1, ECO:0000313|Proteomes:UP000029308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ12615.1}.
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DR EMBL; JPKE01002546; KFZ12615.1; -; Genomic_DNA.
DR STRING; 1420915.A0A094HB57; -.
DR HOGENOM; CLU_000668_0_0_1; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000029308; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 6.10.140.1260; -; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR021601; Phosphatidylino_kinase_fungi.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR Pfam; PF11522; Pik1; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..120
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 691..970
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 170..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1220..1264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1518..1547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1607..1642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1658..1684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1707..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1757..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1870..2018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2039..2086
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2124..2153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2398..2435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2259..2307
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 172..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1022
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1518..1537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1878..1899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1938..1954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1988..2004
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2063..2077
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2129..2143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2406..2426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2703 AA; 291287 MW; 84A253F1603E65C9 CRC64;
MSWDLLKRFI ESDVFNQNPF LSVAYLSRYA DHVGITYVLC SKLRQFSYEE IEFFLPQLCH
LIISLDNESM ALEEFILDLC EESVNGALLT FWLFQTYLHD LSSNPQSTAF KTCRRIYNKV
QRIVFGVTDT ARVEKIKENT LPVTVLASFV LASIGMPGLP RWAGPLAISQ ARKPQESEST
VSDSSQTQKI ARSHTVAGSG SRQRRPKDAL RAASSSDMRL GGESDTKTPR GASLEARPPS
SQSTRKTALD RSTKRPSQFA LQPPDAQSST ISLPLPEPSS PKTVARPLTP LSARFGQRPD
VPHRRHTHQV RPLSPSILNT RQKGKLLRQN YFRSEIQFLT ALENISNRLV MVPKAARLSA
LRAELVLIAQ DLPAEVDIPV ICPATLVDGV PSKSKHHRIV RLNPTECTVL NSAEKVPYLL
MVEVLRDDFT FDPEAAENDA LLKKLLAEQG TSRRRIFDLQ DAPRLPTVEA QQPRSIPDSV
FEPVQGDLGT SPAIQGEDEG QIPAVPDLIG STSTVSSPST ATQSTVQSIT SSHPTPRTSG
NSNSGSSSPG QPRKSTLPLH SRPSGSDQPN YPALATHIRT AAQMLTQLES TSGKRPRSEV
DAIRTKIIAS MQSLEEQSFG GHDTPTFDTI MANANSAPVT NDDEDVEGLA LELVTTGAGA
ARMENDEKTG GVQRKGDRDD PSAAMFGEAW SEKKERIRKS SPYGWMSNWD LISVIVKTGA
DLRQEAFAVQ LIQVCDKIWQ DAGTPVWVKR MRILVTGESS GLIETITNGV SLHSIKRSLT
LATIEAGNNP RGRIATLRDH FVKAFGDPEG EQYKAAVTAF KRSLAAYSII SYVLQLKDRH
NGNVLIDNEG HIVHIDFGFM LSNSPGSVGF EAAPFKLTQD YVDVLGGPNS AEFQDYKSLC
KQAFQALRRS ADNIIDLVSL MGHGSKMPCF QYGVLQATNM LRQRFQLQLS ADEAEKFVET
DLIAKSLGSY YTRLYDTFQY RTQATKASKT PKPKPPQPSP FLRKEPSCRA SLEPRDHLPG
EDSGFKIQPV DQRGQLLKTT TLSEDICDST MSSKGNTNPA PGHRRAKSHD VHSTTIAVEG
HPRPSLPGSV STNSRVFGLG LGFGSAASEP GEFAPAQAAP ETWAPITENA GEGVISALPA
VWTMASNPRS IMATGAPLPP IQKGVTSPDP ARSEAAAATV GPPVSKVATQ GQGSAAVHTP
PNVAGPSDFF EGLIRPVRRG PDRVDRPTAP PQLLPGFVSP RRRRGATIRT GPPTGPNSDI
GRQPVTPELQ VIPSYEQRRE MEDEWLRREE LHRMEWERQR SEFGAVHFHA GSPYRLPFVV
AGQGAPIAPA FAAGSVLLGR ARGNSQASAI EQASAFGNVV PGPSHRPTLV SIPAGGSGAG
GHQARIRSPR AAIGSYIDSP GHGPYLGARR VESQGAHTEY PSPSTPEGMT REMYEMMCAF
SEDVRQEQEE AAEDVKKDEG AAAAAAASCR MPMPGINQHG HLELPRGLSR AEFEAEQAQL
MAGIEAFSEL VNAEEEEVAA AREAEDRRRD ANRHRQPRVD SPGASVSTYY GTGTLDAELW
QQAEDELWDV LNRRKVPSYG ARGELVWPTS PTAAEIAHER AVIFKRARRR AEEAQGASQD
AGRGDDNGGE GPMDRNPQIP FGMPEDLYDQ ACAFNEQVRQ EEAERERTEG LAGPSSSPLP
APLACPPGPI QWGVTEEGLI EAWRRHVAQQ PAESHDPPAD SGRAQHGARP PVHLADPFGE
RDVAAFSRST AAARSGFVGR SGRGSARNAT RAPYHPAEIS TGSPRPRGRG VVVREFFAPP
EHTPLPGRKV TRTPSPSVYS RTSGFGTVQV AVQRPVTGGV SGPDRGDIFR SPSTMLAPVF
SGIQRRNLSS TFEQVNSGSD RVDEESSGEG HEEGGRKGKM VVRNGSAARA SSSSLSDGGS
HGPRWVYESP SVGKMDSGPP RDKGKRKATA EEVAAQVAEE KLLMGTSTST VASEREEGAI
RAPSPVVSLS ETLLNDSGSR DDLSTSPAPP PPPSSAEVLA AVPRGAGAHR TLDLDEGFEF
DAGISPPKST RKKVTGGLRG LAKGLKDKLK TSTRKAKRPL PEPTAAAVPR PEIVDREANQ
STATGLSVGG RARLFASLAG RFTPRPGSSA SAHRPSTAKA GGTGSLGSRR WPARRSSIAR
TFSIPNLRSP SLTADTLNKP LPQTPLFVVR ETASIHEASS ADIEQSVDSV GLRNAAAGQS
LRRGRNVSFA DAPSATRWLQ PSDSVAEIAP AGELEPSPVR AQQQRILELE ASLQVAESSR
SAAEARATAA EENLARALAE LDVYVAEATG HQRALTAQRV DFQMRLDQAT GERDGEAARH
AAETESQHAR HLDYLRVLAS GHLAERQGLE AHIAMLYSAV GGLQTQLLYA GTLPPQGGAG
ARQSLQAAPR AQQDGTASNE PPQQPSSAEF VPGPRLRYGS RLPEPGLFQI LPHPIPLPPQ
QPPFAPSESV QLGVLLRHFL QGCLGATVCS QRGFGLRSEA LFFMAAAWCG VGSQPTWQEI
ELSGSLLALL FMASPSSPGA TNVVLEPISR APRLCSSWSP QSSQPTWWEN RAFRHSPRFV
FPGCPASNSS QRGAGDRAIG QSPRFVSHGC LGTGTKPTSS ETDFFTSSAL LFLASSSGFL
SQFMITDLLS SPAGRSAYLP LPQRRYPLPA FSPPLLLQPG NSTKQPLSGS PDSLLFFSAR
RRL
//
