ID A0A094HN12_9PEZI Unreviewed; 850 AA.
AC A0A094HN12;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 13-SEP-2023, entry version 29.
DE RecName: Full=SET domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V501_02058 {ECO:0000313|EMBL:KFZ16800.1};
OS Pseudogymnoascus sp. VKM F-4519 (FW-2642).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420914 {ECO:0000313|EMBL:KFZ16800.1, ECO:0000313|Proteomes:UP000029315};
RN [1] {ECO:0000313|EMBL:KFZ16800.1, ECO:0000313|Proteomes:UP000029315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4519 (FW-2642) {ECO:0000313|Proteomes:UP000029315};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ16800.1}.
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DR EMBL; JPKD01000737; KFZ16800.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094HN12; -.
DR STRING; 1420914.A0A094HN12; -.
DR HOGENOM; CLU_335591_0_0_1; -.
DR Proteomes; UP000029315; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000029315};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 511..620
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 630..748
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 361..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..831
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 850 AA; 95465 MW; 0FBF1D252F083CF6 CRC64;
MPLTTGEREV IEIPDSPTAH PQFVEISDDE VEVIELLDYQ AKQIKPPRIP PIQPAYVPKG
DGNPESMKSE LADLYTPHDA PMVSLGMAMH IQSFSSDQGH PAGEESCYDV LDRGLGEISR
EMEKDQSSMT RHTLEVQSQF QAQPKFTATE NHMASMQSME AHQQGGTCTS PIAIIHHVAK
KTRPQTFLQG KSIRTPERAV PTYNYYVEID RSRLANNTRL PPEPFVINKN SNSKKEVEAA
LRKSMISCAK LAKRSRGREK LSSIGVYLPQ IRSAYQECRN YLEKEGLYET FGHKDPNHPS
YHVEKAFGIP LGSFFDLETH AAKPQKSPTV SLDPLAKTLE RYSRESCLIC SAHQCHIHGR
FDENDSDVNE SDSSDTTDEE NPSNRSSAMY QPYSMPHTRT QTYYREGNSI ENESEGDSDC
SEQRRLYHCS AACHLNPSNE ELGNEGNWTE DDHASMQELA ASMRTRKNMR ASCLIAPMLG
KQCSEVHRHL KKLSNQRIEL DDMVPGEGRR SKKFDWRDLK VEYMHEKRSQ PRPCHHPGQN
CFVAGEKCTC VSNGICCDKF CTCPQSCDAR YHGCTCTGPC PPKKCTCRLL NRECDPDLCH
KCSVAESVRT QGPISNTKCH NCEIQRGEGK KVLVGESSIE GIGNGLYLAE PVQTGDFIAE
YVGEIIDNAE VERRDDFQKR IGNSYIFNLN AEVAIDSMWF GNATRFINHS EVGKNCQAKV
LLVNSEHRIG FYATESLDAG EELFFDYGKE FKRIEKLKDG VGSSNAERKS AKQQGTEPQE
SPIENTKGGT GDGADEDDER DDIFEDSPDW LATATKGNRA RDDDEDYIEP GSQQGPKRAR
PALRNTRGRR
//
