ID   A0A094HPA4_9PEZI        Unreviewed;       716 AA.
AC   A0A094HPA4;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=ELMO domain-containing protein {ECO:0000259|PROSITE:PS51335};
GN   ORFNames=V502_08324 {ECO:0000313|EMBL:KFZ10086.1};
OS   Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ10086.1, ECO:0000313|Proteomes:UP000029308};
RN   [1] {ECO:0000313|EMBL:KFZ10086.1, ECO:0000313|Proteomes:UP000029308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ10086.1}.
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DR   EMBL; JPKE01002886; KFZ10086.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094HPA4; -.
DR   STRING; 1420915.A0A094HPA4; -.
DR   HOGENOM; CLU_009191_0_0_1; -.
DR   OrthoDB; 1473500at2759; -.
DR   Proteomes; UP000029308; Unassembled WGS sequence.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771:SF56; CED-12; 1.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW   SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT   DOMAIN          256..443
FT                   /note="ELMO"
FT                   /evidence="ECO:0000259|PROSITE:PS51335"
FT   REGION          272..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..603
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   716 AA;  80660 MW;  45B582FDB4640EE7 CRC64;
     MDQAEIPSLL RSLSSDEDAL RKMAVFKLQS SINDPSFADV FISTGGLSIL RRLIMTTGGN
     TLAYSLQSLS RLLEVDMGWE IFESAGAGEL VERVVELIVT HPLVNILRGA MSILVAIVSH
     PQTTRGAIRT PGAFGFRTLK PAVAVYPQFF EMVVSQLNSA DHALCANALM LLNALMRDAI
     TNDGGKEGTS KSSGTGEEWP KFIKRLQDLG VVKGAYRLMQ SSALQDLAHP LLEFQALTKL
     LLRKWREMRV DLERPDHRRA LKGIHLASAP EKREHVTQMG RVEEVSDSAK KGSRKHNPEK
     WRRLGFVTES PAWEFDPMGY LGMMDLTDYV RKQEDNFQKI LLEQSSKPLH TRCPIARCSL
     AVTAILYDHF GADKSETEDA KYYQMLESPQ NYDMIFRPLV LQWSRLHTAG LLAFFRLWKA
     TGAVQDDFDK VAELVRILID KVVGSAPRTK DIQEAEEEIA EFEYHRLREV QMEVLKFSFE
     DQWGHHLQQV REELHNESLQ FVKEQRIRCL LQGSWFPRSA TRGDPNSAAS VRSRPWRFAR
     LSHNRRFLHY ADFDAQAGYA PPLTELAEKL DVGTISSVVS NVTAGGEDDT SSISSSTSTL
     KKEDVNAPPK RNTRNKITVN SYVPTESAEE EQVERVILTL DPQTHSLASE WLDGLLMLLN
     QAPITAETNK LVGLVVDYGL KIRLLNVRLE DGMEAGEGKG LIPTREGLDE DYYYEV
//