ID A0A094HPN5_9PEZI Unreviewed; 1224 AA.
AC A0A094HPN5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit A {ECO:0000256|HAMAP-Rule:MF_03000};
DE Short=eIF3a {ECO:0000256|HAMAP-Rule:MF_03000};
DE AltName: Full=Eukaryotic translation initiation factor 3 110 kDa subunit homolog {ECO:0000256|HAMAP-Rule:MF_03000};
DE Short=eIF3 p110 {ECO:0000256|HAMAP-Rule:MF_03000};
DE AltName: Full=Translation initiation factor eIF3, p110 subunit homolog {ECO:0000256|HAMAP-Rule:MF_03000};
GN Name=TIF32 {ECO:0000256|HAMAP-Rule:MF_03000};
GN ORFNames=V498_07573 {ECO:0000313|EMBL:KFY86207.1};
OS Pseudogymnoascus sp. VKM F-4517 (FW-2822).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420911 {ECO:0000313|EMBL:KFY86207.1, ECO:0000313|Proteomes:UP000029270};
RN [1] {ECO:0000313|EMBL:KFY86207.1, ECO:0000313|Proteomes:UP000029270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4517 (FW-2822) {ECO:0000313|Proteomes:UP000029270};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit A family. {ECO:0000256|HAMAP-
CC Rule:MF_03000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFY86207.1}.
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DR EMBL; JPKA01002113; KFY86207.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094HPN5; -.
DR HOGENOM; CLU_002096_2_1_1; -.
DR Proteomes; UP000029270; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.860; -; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR HAMAP; MF_03000; eIF3a; 1.
DR InterPro; IPR027512; EIF3A.
DR InterPro; IPR000717; PCI_dom.
DR PANTHER; PTHR14005:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A; 1.
DR PANTHER; PTHR14005; EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT; 1.
DR Pfam; PF01399; PCI; 1.
DR SMART; SM00088; PINT; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_03000};
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03000};
KW Initiation factor {ECO:0000256|HAMAP-Rule:MF_03000};
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03000};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_03000}.
FT DOMAIN 496..680
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 136..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 964..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 252..279
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03000"
FT COMPBIAS 143..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1058
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 138282 MW; FCCB41E06815EAAE CRC64;
MYPDFQPTTL ICCAGHANPL SHVCTDSVAV DIGCGGHPAT EEENQKNNRL VVQFGRCQIQ
NALDCMRPSR DVRCCVVEVI VAPAVSKVRG LRFNWTGKRG IFERCKRVGR IEQLNSFDRW
PEIRCAYSLT LSGSTPHPEL QKLESKAAQH HDKTAKMPPP PHQKPENVLK RAHELMGVGQ
SSAALVLLHE HITSKRSRNV PIASLEPVML LLVEQSVEQK KGKLAKDALY QYKNISQNTN
VGTIELVLKK FIELAENKVQ EAQAKADEIQ STLETTQATA SVDDLEASET PESILLSTVS
GEQSRDRTDR AIVTPWLKFL WETYRTVLDI LRNNARLEIM YQSTAMQAFA FCQKYARKTE
FRRLCELLRN HVQTAAKYST QQMHAINLND PDTLQRHLET RFQQLNVAVE LELWQEAFRS
VEDIHTLLNL SKRPPKNIMM ANYYEKLTRI FLVGENYLFH AAAWSRYYNL LRQSAAIVAS
GQGKKSENPA ASEADLTKAA SFVLLSALAI PVISTSRSRG ALIDVDQAKN NKNSRLTHLL
GMSAAPTRAV LFKDAMSKGL LSRARPEIRA LYNILEVDFH PLSICQKISP ILAKIGADEE
MAKYIAPLQQ VILTRLFQQL SQVYETVDVK FVENLARFPA PFDVSRDTIE KFIMNGNKKG
DLAIRLDHAT GVLSFDTDVF SSAKAVHTGS AAGSAESESQ SVQRLQSTPS EIVRTQLTRL
AKSLYVTCQY VDPSYNQARV KARDTALAKA KAGAEQEHQE TLARKEIIHK RKEAANEIIA
RKEKEDATKK KIRAAQLQEA EDKRLAQEQK EREEKRMKAE LDRVRKDELK KQIADLKIGT
KALDIDLEDL DNLDGNRLRA MKLAQLEREK NDTSEKLRIA GKRIDHIERA FRKEEAKKLP
ADYEEQRKRD LEAYDKTKSQ VLRDAEAKHA EDLELSRRLT RITPIYEEFK TDVVARRHDE
FEKRRRDAEK ELEKQISQRR KEHRDRKIRE KREREEQERI LREEEERAAV ELAEKSAREE
RRRQEFAELK AQRDKERQEG LEKATLQARR EEEALARRAG ARNTGGLPVR AAEPERSASS
DRRPPLPLAG AKLGWREKEA LRAAGQEVPS ERTASPAAPT APFARTDSND RPSGPPRLAL
AGAKPSWRDK EAARAASGTS PAPESRDREA PVISRTASGS GPVRGRTDRA ENERESRSPA
PPAEPLKASG GAGKYIPKHL RDKA
//
