ID A0A094HSB3_9PEZI Unreviewed; 893 AA.
AC A0A094HSB3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=amidase {ECO:0000256|ARBA:ARBA00012922};
DE EC=3.5.1.4 {ECO:0000256|ARBA:ARBA00012922};
GN ORFNames=V502_04162 {ECO:0000313|EMBL:KFZ18295.1};
OS Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ18295.1, ECO:0000313|Proteomes:UP000029308};
RN [1] {ECO:0000313|EMBL:KFZ18295.1, ECO:0000313|Proteomes:UP000029308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a monocarboxylic acid amide + H2O = a monocarboxylate +
CC NH4(+); Xref=Rhea:RHEA:12020, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:35757, ChEBI:CHEBI:83628; EC=3.5.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001311};
CC -!- SIMILARITY: Belongs to the amidase family.
CC {ECO:0000256|ARBA:ARBA00009199}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ18295.1}.
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DR EMBL; JPKE01001633; KFZ18295.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094HSB3; -.
DR STRING; 1420915.A0A094HSB3; -.
DR HOGENOM; CLU_009600_4_1_1; -.
DR OrthoDB; 731186at2759; -.
DR Proteomes; UP000029308; Unassembled WGS sequence.
DR GO; GO:0004040; F:amidase activity; IEA:UniProtKB-EC.
DR GO; GO:0043864; F:indoleacetamide hydrolase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.90.1300.10; Amidase signature (AS) domain; 1.
DR InterPro; IPR027450; AlkB-like.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR020556; Amidase_CS.
DR InterPro; IPR023631; Amidase_dom.
DR InterPro; IPR036928; AS_sf.
DR PANTHER; PTHR46072:SF7; AMIDASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR46072; AMIDASE-RELATED-RELATED; 1.
DR Pfam; PF13532; 2OG-FeII_Oxy_2; 1.
DR Pfam; PF01425; Amidase; 1.
DR SUPFAM; SSF75304; Amidase signature (AS) enzymes; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS00571; AMIDASES; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000029308}.
FT DOMAIN 173..342
FT /note="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"
FT /evidence="ECO:0000259|Pfam:PF13532"
FT DOMAIN 402..879
FT /note="Amidase"
FT /evidence="ECO:0000259|Pfam:PF01425"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 99150 MW; F52143ED94C775A2 CRC64;
MIVPDEASTP PKRPHLDARE QPPQFMKDIF KRFQRLPLSE ISTDSHILDF TKGILTQGVR
LDREISSEDL QSIYRRFIGD GKDFDPPKIQ PVYSCEALPG LLILPSFLPS QVQRELLSRL
LHRDLSDPEH QTNVHMFYDM PYPKGDSTPE GASETPSFFS YSPKSKTVFN PKDPSVHKPL
TISKFMEKSL RWVTLGGQYD WTNKVYPDEA PPAFPTDVKD LLEGIFPEMK AQAAIVNLYS
PGDTLSLHRD VSEESDNGLV SISLGCDCLF VVGLGRDPSD TIVMHLRSGD ALLMSKESRF
AWHGVPKILP SSCPTYLASW PAEDNQYEEW RDWMKNKRIN LNTIYGFPER ESAAEIPISG
EQKDVTGKYI QQFLTEREIE ITETDAVGIV AKTTTGAWKA REVTEAFCHR AALAHQLVNC
LHEIFFEAAI ADAQKLDDYY AKHKAPIGPL HGLPISLKDQ FHVRGVETTM GYVGWINTFE
GVKGTGKERV FESEMVRELR ALGGVLYVKT AVPHTLMHGE TVNNVIGYCW NPKNRRLVCG
GSSGGEGALI ACRGASIGLG TDIGGSIRVP SAFNGLYGIR PSVGRLPYEG MANAMQGQNS
ILSVVGPMGT SVGGLRLVMK AILTQKPWLH DPAVHEIPWR SEQEDAVVEL IKSSGKGRQL
SFGIYRHDGV VRPLPPVRRA LDIMVKTIEK LGHKVIDWVP PPHDYASEIA LKTWIFDGGL
DVHQAMGLAG EPLDPAISTI YGTEPVREFQ ASEIAKVNVQ IREYRKQYLD YWNSTAALTG
TGEVVDAFIM PVTPFPAATP MDYPHYDYCT LVNLLDYPSI AIPVTISSAT LDPVDEKFVS
LSGNPLDKKT FDVYDPEVFD GAFVGLQLVG RRLQEERLLA LAEMLGDGIE GPK
//
