ID A0A094HV28_9PEZI Unreviewed; 1269 AA.
AC A0A094HV28;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=V502_04645 {ECO:0000313|EMBL:KFZ17304.1};
OS Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ17304.1, ECO:0000313|Proteomes:UP000029308};
RN [1] {ECO:0000313|EMBL:KFZ17304.1, ECO:0000313|Proteomes:UP000029308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ17304.1}.
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DR EMBL; JPKE01001834; KFZ17304.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094HV28; -.
DR STRING; 1420915.A0A094HV28; -.
DR HOGENOM; CLU_001251_6_0_1; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000029308; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029308}.
FT DOMAIN 537..732
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 916..1210
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..103
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..148
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1269 AA; 143504 MW; 48C1805CEBBF961A CRC64;
MANYQGPRPN GGRQSDYGQP PSSNNQRDAA FSNIFGAAPP PGRSQTMTSS NQSPNMMPPP
GRTQTMGSQY DGRSPMGREP PPRMPPPRQP PPRQPPGGYP PQSPTYGPNG QAGPNGYYQG
PQRPSSNSGP QVRDQQLPPP PPRLDQRRPY PGPQRVDMRQ QPNIPQQQQF AQQQRQPPPR
AYGGPAPAVN SDPYRSQSMA SISRPQMYQA PPSTFQQAPA NAFRHAQYQN NQQMSSKITA
QGRPVPERTH DERTMSMTSY PQGRDHQTMS GRVIPNRRAE EPQERTNGYQ IETPSAAGTA
TRTTSMASTQ VTEGSGRSMS MASTVVAPEI VNNRTSVKSN GSGTGRPRVT TKAPLVYPAL
LSRVGECFRD RIQTGDRTKN DLAYKHAFSG AEAVDVISYI IKTTDRNLAL LLGRALDAQK
FFHDVTYDHR LRDAPTEMYQ FRETMMDDPS DTPEVNGVFV LLTECYSPTC TPDHLCYSIA
CPRRLEQQSR LNLKPQPGLR REDSQANLHD NEPDEQKLWI NTVSKEIADS VGDREKKRQE
VISEIMYTER DFVKDLEYLR DFWIFPLRGL VRDVPPPIPE SRRERIVRTI FSNIVDPPSI
HGVSSKFAES LTERQRKHPV VSAVGDIFLE FVPQFEPFIT YGSNQLNAKF EFEKERSLNP
FFSKFVDETE RRKESRKLEL NGYLTKPTTR LARYPLLLDN VLKYTDPASQ DITDIPKAIK
LIRDLLTRVN AESGKAENRF NLRQLHEQLR FRPNERVDLK LTDEGRELIY KGALKKSPTD
PSEIQAYLFD HAMLLVRVKM VGKKEEVKVY RRPIPLELLA IKEMDDVVPR LGVVKRPTSS
LLPGTKNNTT DTKKEGFPIS FRHLGRKGGY ELTLFASTMG SRKKWLEYID EQQEKLRARG
DFYNKTILSA GFFTAMNRVN CAAPFDGGRK LIYGTDTGIF VSDRRSKEAG AKPKRVIDVQ
NVTQVDVLEE YQLLLVLSAK SLLSFPLSAL DPNEPTLGKR SKKIQSHCNF FKTGICLGRH
LVCCVKSSAL STTIKVFEPN DAMSKGKKQK GFKMFNSGQD ELKAFKEFYI PTESSSIHFL
KSKLCVACAR GFEVVSLETL ETQSLLDQAD TSLDFVARKE NVRPIHIERL NGEFLLNYSE
FSFFVNRNGW RARPDWRIEW EGLPQSFALS YPWILAFEPN FVEIRNIETQ AVHIIPAKNT
RMLHTSTREI LYAFEDERGE DIVASIDFWP AGQRPDARMS IMPPAPSTAP QLPALQIEGG
SSRHSHVRQ
//
