ID   A0A094I7U7_9PEZI        Unreviewed;       724 AA.
AC   A0A094I7U7;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Dethiobiotin synthase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=V502_05068 {ECO:0000313|EMBL:KFZ16526.1};
OS   Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ16526.1, ECO:0000313|Proteomes:UP000029308};
RN   [1] {ECO:0000313|EMBL:KFZ16526.1, ECO:0000313|Proteomes:UP000029308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- PATHWAY: Cofactor biosynthesis; biotin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004746}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ16526.1}.
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DR   EMBL; JPKE01001977; KFZ16526.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094I7U7; -.
DR   STRING; 1420915.A0A094I7U7; -.
DR   HOGENOM; CLU_010794_0_0_1; -.
DR   OrthoDB; 5487177at2759; -.
DR   Proteomes; UP000029308; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR   GO; GO:1901564; P:organonitrogen compound metabolic process; IEA:UniProt.
DR   CDD; cd03109; DTBS; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR005814; Aminotrans_3.
DR   InterPro; IPR049704; Aminotrans_3_PPA_site.
DR   InterPro; IPR022357; MIP_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR42684; ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE; 1.
DR   PANTHER; PTHR42684:SF21; ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE; 1.
DR   Pfam; PF13500; AAA_26; 1.
DR   Pfam; PF00202; Aminotran_3; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
DR   PROSITE; PS00221; MIP; 1.
PE   4: Predicted;
KW   Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        702..721
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   724 AA;  78694 MW;  8A4F0CF1B0263959 CRC64;
     MSTILCGALH RAFPQEPVWY LKPVSTGPLD DADDGHLARF SPSTKTKTLF QFGEPVSPHI
     AARGATPLSD SSIRENIQAH VTSCSQGGKG TLLVETAGGV HSPTPSGSSQ ADLYRPLRLP
     VLLVGDHRLG GISSSISAFE SLHIRGYDLN SVLLFEDEQY QNHEYLRDYF GERGISVLSL
     PPPPPQESSR ETDQARMADY YLEMSERKSV IDMATSLSTS HTSRLDRLDS MADKAHKHIW
     YPFTQHRGIT PEKLMTVDSA HGDFFQTVSP PASETVLQSN LDGSASWWTQ GLGHGNPALS
     LAAANAAGRY GHVMFASAIH EPALALAELL LENLQNPRMQ RVFYSDNGST GVEVAVKMAL
     TAASVRYGYE DAQEVGVIGL KGSYHGDTIG AMDCSEPSTY NERVHWYRGR GHWFDFPQVK
     MKEGTWVVEP PEGGEGDFGP AMKFESLDEV FDMEARDGSP AAQKYRKHIL ETLERLVRVE
     GKTFGALVME PIMLGAGGML LVDPLFQRTL INTIRDSHSL FSASPAPTAP NTWTGLPILF
     DEVFTGLTRL GPFSPSTLLG AQPDISVHAK LLTGGLVPLA ATVASESIYD VFLGDEKRDA
     LLHGHSYTAH AVGCAVAEAS VKELLRIEGG EEWEAFRAPW GKTKVESVPG GKKGVWSMWS
     PTFLDSVSRR GEVESVVALG SVLAIKLRDE NPDFLGGMNR VLIRYCAGVA LSGVMVGVIV
     MRAT
//