ID A0A094IIA8_9PEZI Unreviewed; 850 AA.
AC A0A094IIA8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Beta-mannosidase B {ECO:0000256|ARBA:ARBA00041069};
DE EC=3.2.1.25 {ECO:0000256|ARBA:ARBA00012754};
DE AltName: Full=Mannanase B {ECO:0000256|ARBA:ARBA00041614};
GN ORFNames=V501_00307 {ECO:0000313|EMBL:KFZ20081.1};
OS Pseudogymnoascus sp. VKM F-4519 (FW-2642).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420914 {ECO:0000313|EMBL:KFZ20081.1, ECO:0000313|Proteomes:UP000029315};
RN [1] {ECO:0000313|EMBL:KFZ20081.1, ECO:0000313|Proteomes:UP000029315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4519 (FW-2642) {ECO:0000313|Proteomes:UP000029315};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-mannose residues
CC in beta-D-mannosides.; EC=3.2.1.25;
CC Evidence={ECO:0000256|ARBA:ARBA00000829};
CC -!- PATHWAY: Glycan metabolism; N-glycan degradation.
CC {ECO:0000256|ARBA:ARBA00004740}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. Beta-
CC mannosidase B subfamily. {ECO:0000256|ARBA:ARBA00038429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ20081.1}.
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DR EMBL; JPKD01000117; KFZ20081.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094IIA8; -.
DR STRING; 1420914.A0A094IIA8; -.
DR HOGENOM; CLU_005015_1_1_1; -.
DR Proteomes; UP000029315; Unassembled WGS sequence.
DR GO; GO:0004567; F:beta-mannosidase activity; IEA:UniProt.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR041447; Mannosidase_ig.
DR PANTHER; PTHR43730; BETA-MANNOSIDASE; 1.
DR PANTHER; PTHR43730:SF1; BETA-MANNOSIDASE; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF17786; Mannosidase_ig; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000029315}.
FT DOMAIN 199..303
FT /note="Glycoside hydrolase family 2 immunoglobulin-like
FT beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF00703"
FT DOMAIN 693..777
FT /note="Mannosidase Ig/CBM-like"
FT /evidence="ECO:0000259|Pfam:PF17786"
SQ SEQUENCE 850 AA; 97258 MW; 1662FFC06D235BAB CRC64;
MAGYTNQTLR SGWEFKQVGA TEVPEWTCGF LPVAQFPTNV HLDLMAHDKI PDPFIGLNEY
KVQWVGEQQW LYRTTFECPS VSGRKTILQF DGLDTFAIAS LNGTKILEAE NMHRIFRADI
TGTVEEGVNV LEILFDSAII RGKQLMKETG FKPVGFTSST DKSRLLVRKA QYHYAWNWGP
ELTTCGPWRP IHLEQYSARI SDLHAKVEIS VADKTSSISI SAEIEGGKEG DIIKYALTGP
DGASISTSSA KVTENKATDR FEVHDAKFWW PVGYGEQPLY TIDAHLIREG INIHQRSRKL
GLRTVSLVQR PIVDQPGTSF FFEVNDVPIF SSGSNWCPAD HFVPRVTPER YRTLLQMVVD
GNQNMLRVWG GAIYEDDVFY DICDELGILV WNDFMFACGT YPADEDFRGR ITEEVEDNIK
RLRHHPSIVA WSGNNEDYLF AELFHTSYDI NDPDPDNWLK TTFPARYIYE KMLPEICKKL
IPDTPYHPGS PWGGKYFNDP TIGDTHMWEV WHHVSRPWQE YPKLGSRFIS EFGISSLPHL
DTIESFLIDS PPSERHPNSR TIDHHNKELQ HERKMATYLV ENFKYGFGLE EYIYVTQLNQ
AEAMTCALRA WRREWKGTGK EYCGGSLIWQ FNPTWQVTSK ALVDYFNRPK MAYFTVKRDI
APISLGMERK EIKTPRSEFT RAFIDTETRI LGWATNVTLK PVSYLLTIKA FELSTGKELF
SQTKVQELGA NITTELFDIE LPRPCIVDEP VIMSTCLQTE QGTTIARCTN WPQPYRYINM
PKPKLVIGID DDRISARANV PVKGLAFYSK DVDAVTFDDN MLDLVPGDVQ EIVARGLNGR
AVTWRYYGME
//
