ID   A0A094IYA5_9PEZI        Unreviewed;      1031 AA.
AC   A0A094IYA5;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Pro-apoptotic serine protease NMA111 {ECO:0000256|ARBA:ARBA00020338};
DE   AltName: Full=Pro-apoptotic serine protease nma111 {ECO:0000256|ARBA:ARBA00021524};
GN   ORFNames=V501_09886 {ECO:0000313|EMBL:KFZ01658.1};
OS   Pseudogymnoascus sp. VKM F-4519 (FW-2642).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420914 {ECO:0000313|EMBL:KFZ01658.1, ECO:0000313|Proteomes:UP000029315};
RN   [1] {ECO:0000313|EMBL:KFZ01658.1, ECO:0000313|Proteomes:UP000029315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4519 (FW-2642) {ECO:0000313|Proteomes:UP000029315};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nuclear serine protease which mediates apoptosis.
CC       {ECO:0000256|ARBA:ARBA00002558}.
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ01658.1}.
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DR   EMBL; JPKD01003254; KFZ01658.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094IYA5; -.
DR   STRING; 1420914.A0A094IYA5; -.
DR   HOGENOM; CLU_003212_0_0_1; -.
DR   Proteomes; UP000029315; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.120; -; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR025926; PDZ-like_dom.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR46366; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   PANTHER; PTHR46366:SF8; PRO-APOPTOTIC SERINE PROTEASE NMA111; 1.
DR   Pfam; PF12812; PDZ_1; 2.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000256|ARBA:ARBA00022825};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029315};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          308..380
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   DOMAIN          885..957
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|SMART:SM00228"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1012..1031
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1031 AA;  113363 MW;  B1277BFF3FE31F4E CRC64;
     MTMHGSTRSK RKQHAAPLPE RPQKLHRAVN GKESVGENTP DLGSSSPIDE MEMEMEEEDD
     DRIGIVAPAD SAEWQATIEE VVRNVVSIRF CQTCAFDTDP ALTSEATGFV VDAERGYILT
     NRHVVGSGPF WGYVVFDNHE EVDAYPVYRD PVHDFGILRF DPKAIKYMPV AALELRPDLA
     KVGAEIRVVG NDAGEKLSIL SGVISRLDRN APEYGEGYSD FNTNYIQAAA AASGGSSGSP
     VVNIDGFAVA LQAGGRADGA ATDYFLPVSR PKRALECLQQ GLPITRGTIQ CQWMLKPFDE
     CRRLGLTPEW EAKIRAEFPK ETGMLVAEIV LPEGPSDAKL EEGDILLKVN GELLTQFVRL
     DDILDSNVGQ GVKLVIQRGS EDIEVELAVG DLHKITPDRF ISVAGASFHD LSYQQARLYA
     VACKGVFICE ATGSFKFEGT DSGWLVQSVD HKKTPDLATF IEVMKAIPDR SRVVVTYKHL
     RDLHTLNTSI LYIDRHWSSK MRLAVRNDNT GLWDFIDLAE ALPALPPVPR SASFIQLDNP
     THPAAAELVK SFVRVACHMP VKLDGFPRNR KWGMGVVLDA EKGLVIISRA VVPYDFCDIS
     ITIADSIIVD GKVVFMHPLQ NYAIIKYDPS LVDAPVKSAK LSTEQIKQGA STYFIGFNQN
     MRIVVAQTTV TDITAVAIPA NAGAPRYRAV NLDAITVDTS LSGQCGSGVL VAEDGTVQAL
     WLTYLGERSS TTNKDSDYHL GMATPTLLPV IKQIQAGVTP ELRMLSVEFN AIQMSQARIM
     GVSESWIKNV AAANSAHHQL FMVRKRTFER DQDSHALQEG DVILTLNGNI VTRVSELDVM
     YDSKVLDAVI VRDCVEMHVA VPTVAAHDVE TDRAVNFCGA VLHRPHLAVR QQISKLHSEV
     YVSARTRGSP AYQYGLAPTN FITAVNGVAT PDLEAFIREV VRIPDNTYFR LKCMTFDNVP
     WICTMKKNEH YFATMEWIKD PSEECGWRRV SYEHGESIKG EGKEGINEIA AESIAEDDTG
     AGDTEPVAVK A
//