ID A0A094J4W5_9PEZI Unreviewed; 1338 AA.
AC A0A094J4W5;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=S1 motif domain-containing protein {ECO:0000259|PROSITE:PS50126};
DE Flags: Fragment;
GN ORFNames=V502_10497 {ECO:0000313|EMBL:KFZ03993.1};
OS Pseudogymnoascus sp. VKM F-4520 (FW-2644).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX NCBI_TaxID=1420915 {ECO:0000313|EMBL:KFZ03993.1, ECO:0000313|Proteomes:UP000029308};
RN [1] {ECO:0000313|EMBL:KFZ03993.1, ECO:0000313|Proteomes:UP000029308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM F-4520 (FW-2644) {ECO:0000313|Proteomes:UP000029308};
RA Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA Ozerskaya S.M.;
RT "Population genomics of a fungus Geomyces pannorum provides evidence of
RT horizontal gene transfer but not of sexual reproduction.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in maintenance of chromatin structure during RNA
CC polymerase II transcription elongation thereby repressing transcription
CC initiation from cryptic promoters. Mediates the reassembly of
CC nucleosomes onto the promoters of at least a selected set of genes
CC during repression; the nucleosome reassembly is essential for
CC transcriptional repression. {ECO:0000256|ARBA:ARBA00025022}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SPT6 family.
CC {ECO:0000256|ARBA:ARBA00009253}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KFZ03993.1}.
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DR EMBL; JPKE01004090; KFZ03993.1; -; Genomic_DNA.
DR STRING; 1420915.A0A094J4W5; -.
DR HOGENOM; CLU_001680_0_1_1; -.
DR OrthoDB; 170310at2759; -.
DR Proteomes; UP000029308; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd09918; SH2_Nterm_SPT6_like; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 1.10.10.650; RuvA domain 2-like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.10.2740; Spt6, Death-like domain; 1.
DR Gene3D; 1.10.150.850; Spt6, helix-hairpin-helix domain; 1.
DR Gene3D; 1.10.3500.10; Tex N-terminal region-like; 1.
DR Gene3D; 3.30.420.140; YqgF/RNase H-like domain; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR049540; Spt6-like_S1.
DR InterPro; IPR028083; Spt6_acidic_N_dom.
DR InterPro; IPR042066; Spt6_death-like.
DR InterPro; IPR032706; Spt6_HHH.
DR InterPro; IPR028088; Spt6_HTH_DNA-bd_dom.
DR InterPro; IPR035420; Spt6_SH2.
DR InterPro; IPR035019; Spt6_SH2_N.
DR InterPro; IPR028231; Spt6_YqgF.
DR InterPro; IPR023323; Tex-like_dom_sf.
DR InterPro; IPR023319; Tex-like_HTH_dom_sf.
DR InterPro; IPR017072; TF_Spt6.
DR InterPro; IPR037027; YqgF/RNaseH-like_dom_sf.
DR PANTHER; PTHR10145; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR PANTHER; PTHR10145:SF6; TRANSCRIPTION ELONGATION FACTOR SPT6; 1.
DR Pfam; PF14635; HHH_7; 1.
DR Pfam; PF14641; HTH_44; 1.
DR Pfam; PF14633; SH2_2; 1.
DR Pfam; PF14632; SPT6_acidic; 1.
DR Pfam; PF21710; Spt6_S1; 1.
DR Pfam; PF14639; YqgF; 1.
DR PIRSF; PIRSF036947; Spt6; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158832; Tex N-terminal region-like; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029308};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1113..1182
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1338
FT /evidence="ECO:0000313|EMBL:KFZ03993.1"
SQ SEQUENCE 1338 AA; 154481 MW; 1778261A50AF755F CRC64;
MSMRDLISGE ADVASDEEDD QSFDEETGEA RPRKEQARPD MDDSSEEEED DDDAEAARAV
REGFIIDDEE DEEPEARERR RGKRRRAERE KEEAALDEED LDLIGEANPE WQAKATTDHK
YKRLKRGHRA EDERDRERGL DEIFSEDEAA YDVDEAPRHP LRPDHRNVDE FADFIEEDEL
EDEDQKLRYQ EEMEVARPRD RAYVGAGTEA SGLDKDTLED MEAIFGNGEE YDWALDMEQE
DEIREVGDQQ LELKDVFEPS QLAERLLTDE DNEIRWADEP ERFQLERKAY RHVQITDDQF
KEEAKWITNL IWPKKRPNLP QGSDLQGPFQ KAIGKVLEFF VVDEVEVPYV FQHRKDYLIH
AKRTRLAPDP SNPDQPEYGV TAQKLLNQDD LWRILELDLK FRAFVDKRNI LEKAYDNLKS
ASDVKDEMFE EMLPAAATME ELQDLQEYLH FTYSGQLKDL AVIDGSAKEP QQRRPGSRSS
IFERVRNGQA YNLVRAYGIS AEDIAKNALR EGRKQYTEDP SVRPIELADT LTSDDEFRTG
DQVLLAARQM FSEEMVMSPR MRKHFRMSYF QMGTVSCQRT EKGLRRIDDQ NQYYELKYLR
NMTIPDIARQ PEVFLKMLKA EEEGLLEVRI TMQQERDFRR QLLQEFTSDN YSEVADAWND
ERLKVLDLAF RRLDRIMVKS VKENMRNECE SEVLKACRDE YSKKLDQAPY KPKGMVLGTT
PRVLSLSSGS GDAARGPVYW AWVEDDGRVL ENGQFENLSR DDRSRDEFAE LVQRRKPDVI
GVGGFSIETN KMIKDIRDLV AERDLRGPDF DVRDTNETRN EQLEVVIVND EVARLYRDSP
RALGDYPGLS SVTRYCVALA KYLQNPMKEY AALGSDIISL IFHRCQHLVP EEKLRKQLDT
AMVDMVNLCG IDINEAVGDP YVANLLPYVC GLGPRKATSV IKAINMNGGM VNTRDELVGD
PDSQKLPVVG PRVWNNCASF LSIEYDPSMA SSDYLDNTRV HPEDYELGRK MAADALELDE
EDVKAEVDEN GPGAVVRKLI KDDEQDKVND LILEEYAEQL EQNYNQKKRA TLETIRAELI
QPYEELRRNF AMLSDDDVFT MLTGETNDSL CEGMVVSINV RVVNDEFLIV KLDSGLEGRV
EAYEATDNND VPLPRLFSQG QAAQAKLLSV DRHEFSAKLS LREQEVKRPF RRRLNHMDDQ
WDSNQEARDR EELREKDKVT GRAQRVIKHP LFRPFNSTQA EEYLGSQSSG DAVIRTSSKG
NDHLTVTWKV ADGVYQHIDV LELLKENEFT VGKQLRIGGK YTYSDLDELI VDHVKAMARK
VDEMMQHEKY QKGSKADT
//
