ID   A0A094JNH2_9PEZI        Unreviewed;       936 AA.
AC   A0A094JNH2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Carboxylesterase type B domain-containing protein {ECO:0000259|Pfam:PF00135};
GN   ORFNames=V501_05101 {ECO:0000313|EMBL:KFZ10598.1};
OS   Pseudogymnoascus sp. VKM F-4519 (FW-2642).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus.
OX   NCBI_TaxID=1420914 {ECO:0000313|EMBL:KFZ10598.1, ECO:0000313|Proteomes:UP000029315};
RN   [1] {ECO:0000313|EMBL:KFZ10598.1, ECO:0000313|Proteomes:UP000029315}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM F-4519 (FW-2642) {ECO:0000313|Proteomes:UP000029315};
RA   Leushkin E.V., Logacheva M.D., Penin A.A., Sutormin R.A., Gerasimov E.S.,
RA   Kochkina G.A., Ivanushkina N.E., Vasilenko O.V., Kondrashov A.S.,
RA   Ozerskaya S.M.;
RT   "Population genomics of a fungus Geomyces pannorum provides evidence of
RT   horizontal gene transfer but not of sexual reproduction.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ10598.1}.
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DR   EMBL; JPKD01001647; KFZ10598.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094JNH2; -.
DR   STRING; 1420914.A0A094JNH2; -.
DR   ESTHER; 9pezi-a0a094jnh2; Fungal_carboxylesterase_lipase.
DR   HOGENOM; CLU_006586_10_2_1; -.
DR   Proteomes; UP000029315; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   InterPro; IPR019819; Carboxylesterase_B_CS.
DR   PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR   PANTHER; PTHR11559:SF360; CARBOXYLIC ESTER HYDROLASE; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR   PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029315};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        118..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          161..612
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   REGION          38..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   936 AA;  104953 MW;  553AA1B7AC81141F CRC64;
     MADRLSTPEP CYGILPTGRE VNTTVFCRDR NCSSANHRIP RPDYRTQLSS SSDITQSPYN
     SPSEAEFQKL KVDPEDPQSY GTNRRLSKSS LPAGSSRWNP RHLITQVRAG KLKRKQCILF
     ILAPITIIVV IIIAVVTFVT VRAKKHPNLT VDLGYSQYKG FRTPDGIDKW FGMRYAAPPL
     GDLRFRAPQD PLAASKQDAF QQGKLCHGTP STYLNPTKSE DCLFINVYSP TNRTALHPVY
     FFIQGGGFND LANPYLTGDE LIKAAGNDIV VVTSNYRVGP WGFLASKEIK EDGDLNVGLL
     DQRKALAWVQ KYIHLFGGDP NHVTIDGASA GAASVDLHLT AYGGRDDKLF HAAVGQSNSF
     GAQLTVNESQ YQYDGLVNRT ECRKSTDTLK CLRGLAVEVI ASNNIIMRTP GAKGTPLFMY
     SNVIEGPGGF TEDYTYNMYA DGKFIKVPVI FGSVANEGTL FTPSKTDNVT DMTNFLKNNF
     GKLTTDQLDH IVSLYPHDET KYPGRGAWWR TAADAYGELR YNCPGQFMSR MFENHTDGTS
     NWHYSWDVSP PINTKSGMGA MHAATMYSIW DIATGIGAEL NPTIQAYWTS FIRTKNPNHY
     RLPGTVEWGT FGTGMERLDF PNDPQNVSME AVGASEKARC QYYTLASSQA RNAYPKFQRV
     FVILKPHKFT SLKSHQTRKL ATLILYKNTP NTTIPPVAQT SHSPRAQLPT SGEVYQATMN
     FLGLPKGIDF PLTWRILRMV SAHPYWDLLR LLWPFPWYLR HPLPLPRPQA FTHDHTLFDT
     RNPLIPQIRL VPLFRARDSP IASFYRIYEA MCARDGPAIG SETQYFWRRP EAHWALEGIP
     DPRDPDPVRY AVLASLMEAM VDAFNWRLEL GLRRGGERWV ERGDDGTPAP FVPEVIPAWA
     GRVPALEDEL IMAEGGRGPR FAKRNIIAHE GDLRTV
//