ID A0A094K9R7_ANTCR Unreviewed; 334 AA.
AC A0A094K9R7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Lysophosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00015438};
DE EC=3.1.1.23 {ECO:0000256|ARBA:ARBA00013254};
DE AltName: Full=2-arachidonoylglycerol hydrolase ABHD12 {ECO:0000256|ARBA:ARBA00033386};
DE AltName: Full=Abhydrolase domain-containing protein 12 {ECO:0000256|ARBA:ARBA00032497};
DE AltName: Full=Monoacylglycerol lipase ABHD12 {ECO:0000256|ARBA:ARBA00030575};
DE AltName: Full=Oxidized phosphatidylserine lipase ABHD12 {ECO:0000256|ARBA:ARBA00030502};
DE Flags: Fragment;
GN ORFNames=N321_13960 {ECO:0000313|EMBL:KFZ52569.1};
OS Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes;
OC Caprimulgidae; Antrostomus.
OX NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ52569.1, ECO:0000313|Proteomes:UP000053620};
RN [1] {ECO:0000313|EMBL:KFZ52569.1, ECO:0000313|Proteomes:UP000053620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ52569.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.;
CC EC=3.1.1.23; Evidence={ECO:0000256|ARBA:ARBA00001613};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the serine esterase family.
CC {ECO:0000256|ARBA:ARBA00006584}.
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DR EMBL; KL340465; KFZ52569.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094K9R7; -.
DR ESTHER; fical-u3jdg9; ABHD12-PHARC.
DR Proteomes; UP000053620; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0047372; F:acylglycerol lipase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR12277; ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12277:SF61; LYSOPHOSPHATIDYLSERINE LIPASE ABHD12; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053620};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..211
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFZ52569.1"
FT NON_TER 334
FT /evidence="ECO:0000313|EMBL:KFZ52569.1"
SQ SEQUENCE 334 AA; 38783 MW; ABA995FC768B6305 CRC64;
RRYGLWFRLR KLIIWLLGVY IAIPFLVKLC PTIQAKLVFL NFVRVPYFID LKRPQDQGLN
HTCNYYLQPE EDVTVGVWHT VPAALWKNAR GKDQLWFEDA LGSSHPVILY LHGNAGTRGG
DHRVELYKVL SSLGYHVVTF DYRGWGDSIG SPSERGMTYD ALHVFDWIKA RSGDNPVYVW
GHSLGTGVAT NLVRRLCERE TPPDALILES PFTNIREEAR SHPFSIYRYF PGFDWFFLDP
ITTSGIKFAN DENVKYISCS LLILHAEDDP VVPFHLGKKL YNIAATSRSF RDYKVQFVPF
HTDLGYRHKY IYRSPELPRI LREFLGKSEH EHHH
//
