ID A0A094KKZ6_ANTCR Unreviewed; 505 AA.
AC A0A094KKZ6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Cholesteryl ester transfer protein {ECO:0000256|ARBA:ARBA00022354, ECO:0000256|PIRNR:PIRNR037185};
GN ORFNames=N321_06687 {ECO:0000313|EMBL:KFZ58082.1};
OS Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes;
OC Caprimulgidae; Antrostomus.
OX NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ58082.1, ECO:0000313|Proteomes:UP000053620};
RN [1] {ECO:0000313|EMBL:KFZ58082.1, ECO:0000313|Proteomes:UP000053620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ58082.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the transfer of neutral lipids, including
CC cholesteryl ester and triglyceride, among lipoprotein particles. Allows
CC the net movement of cholesteryl ester from high density
CC lipoproteins/HDL to triglyceride-rich very low density
CC lipoproteins/VLDL, and the equimolar transport of triglyceride from
CC VLDL to HDL. {ECO:0000256|PIRNR:PIRNR037185}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-
CC octadecenoyl)-glycerol(out); Xref=Rhea:RHEA:43352, ChEBI:CHEBI:53753;
CC Evidence={ECO:0000256|ARBA:ARBA00001417};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl
CC (9Z,12Z)-octadecadienoate(out); Xref=Rhea:RHEA:43356,
CC ChEBI:CHEBI:41509; Evidence={ECO:0000256|ARBA:ARBA00001140};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-
CC octadecenoate)(out); Xref=Rhea:RHEA:43348, ChEBI:CHEBI:46898;
CC Evidence={ECO:0000256|ARBA:ARBA00000222};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037185}.
CC Note=Secreted in plasma. {ECO:0000256|PIRNR:PIRNR037185}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000256|PIRNR:PIRNR037185}.
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DR EMBL; KL349613; KFZ58082.1; -; Genomic_DNA.
DR RefSeq; XP_010166072.1; XM_010167770.1.
DR AlphaFoldDB; A0A094KKZ6; -.
DR GeneID; 104524786; -.
DR KEGG; acar:104524786; -.
DR CTD; 1071; -.
DR OrthoDB; 5355726at2759; -.
DR Proteomes; UP000053620; Unassembled WGS sequence.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-UniRule.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0034375; P:high-density lipoprotein particle remodeling; IEA:UniProtKB-UniRule.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:InterPro.
DR GO; GO:0034197; P:triglyceride transport; IEA:UniProtKB-UniRule.
DR GO; GO:0034372; P:very-low-density lipoprotein particle remodeling; IEA:UniProtKB-UniRule.
DR CDD; cd00025; BPI1; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR017130; Cholesteryl_ester_transfer.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47616; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR PANTHER; PTHR47616:SF1; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR PIRSF; PIRSF037185; Cholesteryl_ester_transf; 1.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037185-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Reference proteome {ECO:0000313|Proteomes:UP000053620};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037185};
KW Signal {ECO:0000256|PIRNR:PIRNR037185};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221,
KW ECO:0000256|PIRNR:PIRNR037185};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037185}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|PIRNR:PIRNR037185"
FT CHAIN 25..505
FT /note="Cholesteryl ester transfer protein"
FT /evidence="ECO:0000256|PIRNR:PIRNR037185"
FT /id="PRO_5015219182"
FT DOMAIN 40..267
FT /note="Lipid-binding serum glycoprotein N-terminal"
FT /evidence="ECO:0000259|SMART:SM00328"
FT DOMAIN 281..488
FT /note="Lipid-binding serum glycoprotein C-terminal"
FT /evidence="ECO:0000259|SMART:SM00329"
FT DISULFID 169..210
FT /evidence="ECO:0000256|PIRSR:PIRSR037185-50"
SQ SEQUENCE 505 AA; 56949 MW; 73959B23ACBF337D CRC64;
MLWAGRMRLG TFGILLMLVH ASAACEFEPF PYSVTGIVCR MTKPAALLLN QETAQVIQAA
FRNAKFPNIT GERSMRLLGK VAYGLTNIQV NDLSIEQSEV ELKENDAIYI AIKNVTAFFK
GTLTYGYAGA WFLQLFHSVD FEIESSIDLQ INIKLMCQKD QVAADASDCY LSFHKLILHL
QGEKEPGWLK QLFTDFISFT LKLVLKSEVC NEINFLAQVL ANFVHDLAAN FVQDEDISVD
ISLASVPLIK ANYLESHHKG LVLYKNYSDV FSDSVFSPLL LTESRMLYFW LSEHILNSLA
SAAFLDKRLM LTIKGEKLQA LFEMEDTDAQ RKAVQMIFQG ASYNDSMAKV WSLAQPQISL
QPEGTVVKSL VAVEVSIFPL GEEPLMVLYM EKEIMVTIQA AYAEKKLILH PLDSRIEFKV
FKCTADPSGN DPSIRNFLQT MISVVGIPEV ISRIEPALTS LMNSKGLHLF EIRNPEIITR
KGYVIVQLDF SFPNHLLLDF LEKRL
//
