ID A0A094L2W6_ANTCR Unreviewed; 260 AA.
AC A0A094L2W6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Pro-thyrotropin-releasing hormone {ECO:0000256|PIRNR:PIRNR001795};
GN ORFNames=N321_06568 {ECO:0000313|EMBL:KFZ58484.1};
OS Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes;
OC Caprimulgidae; Antrostomus.
OX NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ58484.1, ECO:0000313|Proteomes:UP000053620};
RN [1] {ECO:0000313|EMBL:KFZ58484.1, ECO:0000313|Proteomes:UP000053620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ58484.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a regulator of the biosynthesis of TSH in the
CC anterior pituitary gland and as a neurotransmitter/ neuromodulator in
CC the central and peripheral nervous systems.
CC {ECO:0000256|PIRNR:PIRNR001795}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TRH family. {ECO:0000256|ARBA:ARBA00010437,
CC ECO:0000256|PIRNR:PIRNR001795}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL350266; KFZ58484.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094L2W6; -.
DR Proteomes; UP000053620; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008437; F:thyrotropin-releasing hormone activity; IEA:InterPro.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:UniProtKB-UniRule.
DR InterPro; IPR008857; TRH.
DR PANTHER; PTHR17530; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR PANTHER; PTHR17530:SF2; PRO-THYROTROPIN-RELEASING HORMONE; 1.
DR Pfam; PF05438; TRH; 1.
DR PIRSF; PIRSF001795; TRH; 1.
PE 3: Inferred from homology;
KW Hormone {ECO:0000256|PIRNR:PIRNR001795};
KW Reference proteome {ECO:0000313|Proteomes:UP000053620};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001795};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|PIRNR:PIRNR001795}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT CHAIN 24..260
FT /note="Pro-thyrotropin-releasing hormone"
FT /evidence="ECO:0000256|PIRNR:PIRNR001795"
FT /id="PRO_5010009707"
FT REGION 58..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 260 AA; 30078 MW; 5177EA775AF142DD CRC64;
MPSIQLLLLL LCLTLCGVCL NRGQPLPEGS EDRGRNPLDD ILQRSESLIL QSVLKKAEKG
EAMNKESNAP LPEWLSKRQH RGKKFLSDLE KRQHPGKRDV EEDTPYGNIQ KRQHPGKREI
EDDLDGYMEL KKRQHPGRRS LPDEYADIPS AQLTYLNEIS KRQHPGRRYL MYKWQQPSKR
GWNDEVDLND QYGEKRQHSG KRHWNSDSLD DAGPCNFQES FTCNKGSLLL DLVENVSKGR
VEEKRQHPGK RSAWGSETEE
//
