ID   A0A094LK20_ANTCR        Unreviewed;       538 AA.
AC   A0A094LK20;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Polycystic kidney disease 2-like 2 protein {ECO:0000313|EMBL:KFZ64219.1};
DE   Flags: Fragment;
GN   ORFNames=N321_04242 {ECO:0000313|EMBL:KFZ64219.1};
OS   Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes;
OC   Caprimulgidae; Antrostomus.
OX   NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ64219.1, ECO:0000313|Proteomes:UP000053620};
RN   [1] {ECO:0000313|EMBL:KFZ64219.1, ECO:0000313|Proteomes:UP000053620}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ64219.1};
RA   Zhang G., Li C.;
RT   "Genome evolution of avian class.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004272}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004272}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the polycystin family.
CC       {ECO:0000256|ARBA:ARBA00007200}.
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DR   EMBL; KL359101; KFZ64219.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094LK20; -.
DR   Proteomes; UP000053620; Unassembled WGS sequence.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   InterPro; IPR003915; PKD_2.
DR   InterPro; IPR046791; Polycystin_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10877:SF47; POLYCYSTIC KIDNEY DISEASE 2-LIKE 2 PROTEIN; 1.
DR   PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR   Pfam; PF08016; PKD_channel; 1.
DR   Pfam; PF20519; Polycystin_dom; 1.
DR   PRINTS; PR01433; POLYCYSTIN2.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   3: Inferred from homology;
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053620};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        188..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        318..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        380..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..183
FT                   /note="Polycystin"
FT                   /evidence="ECO:0000259|Pfam:PF20519"
FT   DOMAIN          184..408
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   DISULFID        52..65
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KFZ64219.1"
FT   NON_TER         538
FT                   /evidence="ECO:0000313|EMBL:KFZ64219.1"
SQ   SEQUENCE   538 AA;  62786 MW;  5E1A42C288801FA6 CRC64;
     FAEGPLLDGL YWDTWYNNTT LTFQNNNSHI YYENLLLGVA QIRQLKVRNN TCSIYPYFHT
     LLEDCYSEYR YRAEDRSNFG LWNKSEWKYT SASSLAPWYW GSMGLYSSGG YMFTLPKSKQ
     ESVEKLVFLR NNSWLTRGTR VVFIDFSTYN ANLNLFCTVR LVVEFPATGG AFTSSHIYSV
     KLLRYVTYYD YFLASCEIAF CIFIIIFIIQ EVIKIVKLKK EYFRSAWNWL DLLLLVVSIL
     AIAFNIYRTV KVSQLMEELL SDAHAYPDFY FLAFWQVLYN NMIAVNIFFA WIKIFKYVSF
     SKTMTELSST LSRCAKDIIG FAIMFFIIFF AYAQLGYLVF GSQVEDFSSF QNCIFTQFRI
     VLGDFNFETI EAANRILGPI YFITFVFFVF FILLNMFLAI INDTYSEVKA DFEVIPSQEL
     QLRDLFRESC NKALVKLKLK KPEMDANLAD ESTESHAGFS CDFFFFKPSA AERSHLKLSK
     LQQEKEELHP STEDTDLVTA QSYVSTAEFQ QLFRYTAELA KELNNTNAKL RKVIKSVQ
//