UniProt: A0A094LS77

Database: UniProt
Entry: A0A094LS77_9GAMM

LinkDB:  A0A094LS77_9GAMM 
Original site:  A0A094LS77_9GAMM

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (9)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (20)   

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ID   A0A094LS77_9GAMM        Unreviewed;       792 AA.
AC   A0A094LS77;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=HR45_05935 {ECO:0000313|EMBL:KFZ38048.1};
OS   Shewanella mangrovi.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=1515746 {ECO:0000313|EMBL:KFZ38048.1, ECO:0000313|Proteomes:UP000029264};
RN   [1] {ECO:0000313|EMBL:KFZ38048.1, ECO:0000313|Proteomes:UP000029264}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YQH10 {ECO:0000313|EMBL:KFZ38048.1,
RC   ECO:0000313|Proteomes:UP000029264};
RA   Liu Y., Zeng R.;
RT   "Shewanella sp. YQH10.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KFZ38048.1}.
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DR   EMBL; JPEO01000003; KFZ38048.1; -; Genomic_DNA.
DR   RefSeq; WP_037440669.1; NZ_JPEO01000003.1.
DR   AlphaFoldDB; A0A094LS77; -.
DR   STRING; 1515746.HR45_05935; -.
DR   eggNOG; COG0417; Bacteria.
DR   OrthoDB; 5807460at2; -.
DR   Proteomes; UP000029264; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd05784; DNA_polB_II_exo; 1.
DR   CDD; cd05537; POLBc_Pol_II; 1.
DR   Gene3D; 3.30.70.2250; -; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029264};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN          157..302
FT                   /note="DNA-directed DNA polymerase family B exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF03104"
FT   DOMAIN          388..768
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
SQ   SEQUENCE   792 AA;  89114 MW;  85C995B68DFBEFEE CRC64;
     MTKQYQTVSG RVLTRHWRRH NACSVLQYYL NTAQGPVLVE VADAEQVFFV NDSQAPQLLA
     HHHNAQHRSV ALKSFDNMPV AAVYSSTPAT TRAILASARD KNIALYESEI KPQQRFLIER
     YIALDAEFYG QFVQGHSATL PVFSATKARA TRAVDIPMKV VSLDLECAPD GQLYSAAVYG
     AATDGTNSIA KVFMVGQPQS TPQDIVWVAN EGALLTALID WFQDWDPDVI IGWSVIAFDL
     ALLSKRCTAL GIPANFGRFY SALEWLVEGT YRPETMVLPG RVVLDGIDWL KAAFYQFESF
     ALDFVAKALL GEGKTIEHAS QHKVSEINRM FAEDKLSLAH YNLTDCRLVW DIFKQTDLLA
     FAVARAQLTG LEFGRVGASV AAFNNLYLPH LHRAGYVAPA MPASDGLESP GGYVMDSIPG
     LYRDILVLDF KSLYPSIIRT FLVDPLGLVT AKYLPENETV EGFLGARFSR EGHILPDLVG
     KLADAREQAK KQDNKPLSQA IKIIMNSLYG VLGSKGCVFH DAKLASSITM RGHQIMQQTK
     AWIESKGFTV IYGDTDSTFI WLGEQHQIED IHAFGHQLAK EINQLWQEYI DTHFRLTSYL
     ELEFDNHFSQ FLMPTLRGSD EGSKKRYVGL KSLTDGHSEL VFKGMEQVRS DWSPLAKRVQ
     YELYRRLFNN EDVCAYLREQ MQCITDGQCD AELVFSKRLR RDIAAYQSKS IPHVKAAQRL
     VELTHDAKYS RKGTRIRYVM TNNGAVPIET PNIIPDYQYY LDKQIRPIAE PILNILGVEF
     DQLMSSQLAF KI
//

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