ID A0A094MSQ8_ANTCR Unreviewed; 4093 AA.
AC A0A094MSQ8;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=N321_06511 {ECO:0000313|EMBL:KFZ57601.1};
OS Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes;
OC Caprimulgidae; Antrostomus.
OX NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ57601.1, ECO:0000313|Proteomes:UP000053620};
RN [1] {ECO:0000313|EMBL:KFZ57601.1, ECO:0000313|Proteomes:UP000053620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ57601.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
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DR EMBL; KL348898; KFZ57601.1; -; Genomic_DNA.
DR Proteomes; UP000053620; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KFZ57601.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053620};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2871..3503
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3687..4018
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4061..4093
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT COILED 3553..3580
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFZ57601.1"
FT NON_TER 4093
FT /evidence="ECO:0000313|EMBL:KFZ57601.1"
SQ SEQUENCE 4093 AA; 468455 MW; 957824D58B84C623 CRC64;
GFSTALHLSL VFSQEHGLLV FIHRSLSIEE FRDCREEALK FLCVFMEKVG DKVHPYACNI
KQTCISVYTK ERAAKCKVPA LELLIKLLQN LRRSCLMEEM KVGDIFNKFY GELAVKSKVP
DTVLEKIYEL LGVLGDVQPS DMINNSEKLF RAYLGELKAQ MTSAIRGPKL PVVAGCLRGL
AALMCNFTKS VDEDPQTAKE IFDFAVKAIN PQVDQKRYAV HLAGLQLFSW HAAQFGALLL
DNYVLLFEAM CKWCGHTNQE LKKASHSALD SFLKQISLMV AKDVELHRSK LQFFMEQFYG
IIRRMDSSSK ELSIAIRGYG LFAAPCKAIH SKDVDDMYVE LLQRCKQMYL TEAETIDDHL
YQLPSFLQSI ASVIFHTDTI PEVYTPVLEH LVVLQINSFP HYSEKMQLVC CRSIIKVFLS
LSGKGPVLWS FISTVVHQGL IRIFSKPITF SKDFFGKETS GSEESREAGE VGTGRWKVPT
YKDYLYLFRS LLSCDTMKEC GFEDENFLAE NSPLQSLNRL LYDELIKSIL KIIEKLDLTV
QKLDVNEQDE NEMDSALVGP SSDPASNLQP TKPTDFIAFI NLVEFCREIL PEKHVEYFNP
WVYSFGYELI THSTRLPLIS GFYKLLSVTM KIAKKIKYFE GVSPRSLRKC PEDPEKRSCF
ALFVKFGKEV AAKTKQYKDE LLASCLNFLL SLPHDIIMLD IKAYIPALQN AFKLGLSCTP
MADLGLDALE DWSAHIPRHI MQPYYKDVLP LLDGYLKNST STVESQNNWE VRKLSRAAQK
GFNKVVIQRL RKAKTFSLDD SSSLEAVRAR VAHLLGSLGG QINHNLITAT SAEEMMRKCV
SWDTEMRLSF AVPFADMKPV IYLDLFLPRV TELALSASDR QTKVAACELL HGIVTYMLGK
ASQMPERRQG PPPMYQLHKR IFPVLLRLAC DVDQVTRQLY EPLVMQLIHW FTNNKKFESQ
YTLAFLESIL SGIVDPVDST LRDFCGQCIQ EFLKWSIKQT TPRQQEKSPA NTKSLFKRLY
SLALHPSAFK RLGAALAFNS IYREFREENS LVEQFVFEAL VVFLESLALT HTDEKSLGTA
QQCCDTINHL KRIIKHKAPS LNKEGKRRVP RGFPATKSVC LLDIVMWLLV QCGRPQTECR
HKAMELFYEF VPLLPGNKSP SSWLADVLKK RDVSFLIKKF EGGGSNAKSP SGILSQPTLR
GMQEPFSLQT VMRWMDMFLA ALDCYNTFFE LRMIKPHEIL SVNERSSFLE AVQFFLETIA
LHDIHAAEQC FEGSSKGSMF SPQERDMYNY SKCTIIVRIL EFVTMILETC QQDFWKLLEK
ELLNAKLIEL LVMTVCDPSH VGFNTADVQV MKNLPDISVK LMKALMKSPY KESLKLYIKK
KITLQSLEDL CSVDLFNSDA RFDQVRFSAV LSACKQLQKS GLLHSVLHDQ DEGPHFSVGS
KLLSAVYKGI APGGERLSLP SLDISSKRLA DRLLQLAFAI DDQCEELVSL LLNTVVLSVP
LSGTSQKNLI NFSHGQYFYS LFSETINLQL LKNVDVIIVQ LMESSVSNPQ MVGSILNGML
DQSFRERTVR KQQGVKLVTA VLRNWKKLDS WWAKGSAPES KVAVLTLLAK VLQIDSSVSF
NTNHEAFTAV FNTYTSLLTD ENLGLNLKGQ AVIILPFFTN LTGEKLYDLK NALDQLVAFS
FPMRSDEFPK GTLKHNNYVD CTKKFLDALE LSQSPMLLQL MTEVLCRDHR HFMEDLFQAS
FKRISRRSTT EKQVILLDTV HKMFQSEDLL SNTTRQAFLD RSLLTLLWHC NLDALREFFG
KIIVQAMDAL SSRFTKSNEY TFDTQVTKKM GYYKLLEVMY VRLSKEDVYS KDSKINQAYC
GSVSVEGNEL TKTLIKSCYD AFTENMAGES QLLEKRRQYH CAAYNCAIAV ISCVFTEIKF
YQGFLFTEKS EKNLLIFENL IDLKRQYTFP IEIEMPLERK KRYIAIRKEA RDAGSSDQDE
PKYLASASYM MDSSLSEEMS QFDFSTGVQG FSYSSQDVTA SSNRFRRKEA TEYMVLNDEM
ELEMDELNQH ECMASMTSLI KHMQRNQISP KLEEAIPVDL PLWMKFLHGK LGNPSVPLNI
RLFIAKLILN TEDVFRPYAK QWLGPLLQLV VSGNNGGEGI HYMVVEIVVT ILSWTSVTTP
KGNIKDEILA NRLLEFLMKN AFHQKRAVFR HNLEIIKTVI ECWKNCLSIP YSLIFEKFSN
GDPDTKDNSV GIQLLGIVLA NNLPPFDPKC EIDRVRYFQA LTSNMALLKY KEVYAAAAEV
LGLALQYIAE RENVLEDPVY DCVIRQLKHH QNTQQDKFIQ CLNKVVKNFP PLADRFMNAV
FFLIPKLHGI MKTYCLEVVM CRAEEIPDLH LQLKSKDFIQ IMNHRDDERQ RVCLDIVYKM
LSKLKPLELK ELLPGVTGFI SHPSVICRQR MYDILMWIYD NYSDPESQAD GDSQEILKLV
KEILLQGLID ENAELQLIVR NFWSDETRLP ANILDRMLAL LNSLYSTKIE TQYLSLITNF
LLEMTSKSPD YSRKIFEHPL SECKFQDFVI DSSWRYRSTV LTPMFVETQA SQSIHRNLSQ
ERSLSASGSV SGRVRATQRQ YEFTPTQHVS GRSSFNWLTG NSVDTLSEYT VPSSSESLSS
SMLLVNKRSE KFKQTTFKPV GPDFGKKRLS LPGDEVDSKT KGIEERAEIL RLRRRFLKDQ
EKLSLIYARR GVAEQKREKE MKSELKMKYD AQVTLYRSYR VGDLPDIQIE YCSLIAPLQG
LAQKDPTFAK QLFSSLFGGI FHEVEKSKTP SEKKVIIQKL LNNFNNFLSM SLSYFPPFIA
CIQETSCQHR ELLELDSANV STSCLASLQQ PVGILLLERA LMALSPAEEP PSKRMRGRTE
LPPDVIRWIE LAKLYRSLGD YDVLRGIFSG KIGTKEITQK ALLAEARSDY AEAAKYYDEA
LSKEDWQDGE PTEAEKDFWE LASLECYDHL TEWKSLEYCA TINIDSGKPP DLSKTWNDPF
FQETYLPYII RSKLKLLLNG ENDQTLLTFI DEAMKTEQKK AIIEMHYSQE LSLLYILQDD
FDRAYYYISS GMQIFMQSYS SIDTLLYQSR MTKLQSLQAL TEIQDFINFM TRRSNLASQA
SLKRLLRIWT SRYPDAKMDP MNIWDDIITN RCFFLDKLQE KLLCDQANDS MDIDEEYGAG
DQMEVDQRDE DIYSMIKSCK FNMKMKMIES ARKQSSFSVA KKLLKDLRKE AKTREDWLVR
WNYAYCHFTH SCSRNQSCPE RMLSVLKTIS LLEDTKSDYL SKNITAFRNK NLLLGTTYRI
MANALSQDPR CLEQIEEEKA GKISVLSGES LHSPEKVLAG LNKKAFQCYS SAARKSEEEV
QSHSTGHVDV MGVIDAYMTL VGFCDQHLRR EEEGLLEINT ADLQLFPAIV VEKMIKALKL
NSKEARLRFP RLLQIIERYP AETLGLVTRE LPSVPCWQFI GWISQMMALL DKDEAVAVQH
TVEEIANTYP QAIIYPFMIS SESYCFKDTA TGCKNKEFVE RIKNKLDRGG VVQDFVCSLE
QLSNPVMLFK DWVEDVRNEL VKAQRNKNKL KEMYEGMYKN LGNLEAPGLG LLRKRFIQAF
GKDFDHHFGK GGSELLDMKA SDFDAIATSL LSKMNKNHHK EPGNLKECSP WMSEFKAEFL
RNELEVPGQY DGKGKPLPEY HAKISGFDER ISVMESLRKP KRITIRGSDE QEYPFLVKGG
EDLRQDQRIE QLFDVMNIIL SQDATCSQRN MQLKTYQVIP MTTRLGLIKW LENTCTLKEF
LKNSMSEEED ISYNSKKGPR ATYSEWLSKM GGKAQGISRY HVMYRNASRT EAVMSFKSRE
SSVPEDLLRR AFVKMSTSPE AFLSLRSHFA SSHALMCISH WILGIGDRHL SNFMINKETG
GMVGIDFGHA FGSATQFLGV PELMPFRLTR QFVNLMMPVK EWGLIYSVMV HALRAYRADP
DLLISTMDVF VKEPSLDWKN FEQRQLKKGG TWIKEINTSE VNWYPLQKVS YVKRKLTGAN
PATVTCDELR LGHEKSPSYN DFAAVARGNA DYNIRAKEPE DGLSEETQVR CLIDQATDPN
LLGRVWEGWE PWM
//
