ID A0A094MYJ6_ANTCR Unreviewed; 1752 AA.
AC A0A094MYJ6;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:KFZ59541.1};
DE Flags: Fragment;
GN ORFNames=N321_13563 {ECO:0000313|EMBL:KFZ59541.1};
OS Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes;
OC Caprimulgidae; Antrostomus.
OX NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ59541.1, ECO:0000313|Proteomes:UP000053620};
RN [1] {ECO:0000313|EMBL:KFZ59541.1, ECO:0000313|Proteomes:UP000053620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ59541.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KL352022; KFZ59541.1; -; Genomic_DNA.
DR Proteomes; UP000053620; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053620}.
FT DOMAIN 170..365
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 494..652
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 1697..1752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1715..1741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFZ59541.1"
FT NON_TER 1752
FT /evidence="ECO:0000313|EMBL:KFZ59541.1"
SQ SEQUENCE 1752 AA; 197388 MW; 844B90319CFEF6C0 CRC64;
RDLDQASMEA VVSLLAGLPL QPEEGDGVEL MEAKSQLFLK YFTLFMNLLN DCSEVEDESA
QTGGRKRGMS RRLASLRHCT VLAMSNLLNA NVDSGLMHSI GLGYHKDLQT RATFMEVLTK
ILQQGTEFDT LAETVLADRF ERLVELVTMM GDQGELPIAM ALANVVPCSQ WDELARVLVT
LFDSRHLLYQ LLWNMFSKEV ELADSMQTLF RGNSLASKIM TFCFKVYGAT YLQKLLEPLL
RTVITSSEWQ HVSFEVDPTR LEPTESLEEN QRSLLQMTEK FFHAIINSSS EFPPQLRSVC
HCLYQVVSQR FPQNSIGAVG SAMFLRFINP AIVSPYEAGI LDKKPPPRIE RGLKLMSKIL
QSIANHVLFT KEEHMRPFND FVKSNFDAAR RFFLDIASDC PASDTVNHSL SFISDGNVLA
LHRLLWNNQE KIGQYLSSNR DHKAVGRRPF DKMATLLAYL GPPEHKPVAD THWSSLNLTS
SKFEEFMTRH QVHEKEEFKA LKTLNIFYQA GTSKAGNPVF YYIARRFKTG QINGDLLIYH
VLLTLKPYYA KPYEIVVDLT HAGPSNRFKT DFLSKWFVVF PGFAYENVSA VFIYNCNSWV
REYTKYHERL LTGLKGSKRL IFIDCPGKLA EHIEHDQQKL PAATLALEED LKVFHNALKL
AHKDTKVSIK VGSTAVQVTS AERTRVLGQT VFLNDIYYAS EIEEICLVDE NQFTLTIANQ
GTPLTFMHQE CEAIVRSIIH IRTRWELSQP DSIPQHTKIR PKDVPGTLLN IALLNLGSSD
PSLRSAAYNL LCALTCTFNL KIEGQLLETS GLCIPANNTL FIVSISKTLA ANEPHLTLEF
LEECISGFSK SSIELKHLCL EYMTPWLSNL VRFCKHNDDA KRQRVTAILD KLITMTINEK
QMYPSIQAKI WGSLGQITDL LDVVLDSFIK TSATGGLGSI KAEVMADTAV ALASGNVKLV
SSKVIGRMCK IIDKTCLSPT PTLEQHLMWD DIAILARYML MLSFNNSLDV AAHLPYLFHV
VTLLVATGPL SLRASTHGLV INIIHSLCTC SQLHFSEETK QVLRLSLTEF SLPKFYLLFG
ISKVKSAAVI AFRSSYRDRS FSPGSYERET FALTSLETVT EALLEIMEAC MRDIPTCKWL
DQWTELAQKF AFQYNPSLQP RALVVFGCIS KRVSHGQIKQ IIRILSKGLE SCLKGPDNYN
SQVLIEATVI ALTKLQPLLN KDSPMHKALF WVAMAVLQLD EVNLYSAGTA LLEQNLHTLD
SLRVFNDKSP EEVFMEIRRP LEWHCKQMDH FVGLNFNSNF NFALVGHLLK GYRHPSPTTV
ARTVRILHTL LTLVNKHRNC DKFEVNTQSV AYLAALLTVS EEVRSRCSLK HRKSLLLTDV
SMENVPMDTY PIHHSDTSYR TLKENQPWSS PKGSDRHLAA SYPTVGQISP RTRKSMSLDM
GQPSQANTKK LLGTRKSFDH LISDTKAPKR QDMESGITTP PKMRRVAEND YDMETQRISP
QQHPHLRKVS VSESNVLLDE EVLTDPKIQA LLLTVLATLV KYTTDEFDQR ILYEYLAEAS
VVFPKVFPVV HNLLDSKINT LLSLCQDPNL LNPIHGIVQS VVYHEESPPQ YQTSYLQSFG
FNGLWRFAGP FSKQTQIPDY AELIVKFLDA LIDTYLPGID EETSEESLLT PTSPYPPAVQ
SQLSITANLN LSNSMTSLAT SQHSPGIDKE NVELSPTAGH SNSGRMRHGS ASQVQKQRSA
GSFKRHSIKK IV
//
