ID A0A094NB13_ANTCR Unreviewed; 285 AA.
AC A0A094NB13;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
DE Flags: Fragment;
GN ORFNames=N321_03161 {ECO:0000313|EMBL:KFZ63716.1};
OS Antrostomus carolinensis (Chuck-will's-widow) (Caprimulgus carolinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Caprimulgimorphae; Caprimulgiformes;
OC Caprimulgidae; Antrostomus.
OX NCBI_TaxID=279965 {ECO:0000313|EMBL:KFZ63716.1, ECO:0000313|Proteomes:UP000053620};
RN [1] {ECO:0000313|EMBL:KFZ63716.1, ECO:0000313|Proteomes:UP000053620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BGI_N321 {ECO:0000313|EMBL:KFZ63716.1};
RA Zhang G., Li C.;
RT "Genome evolution of avian class.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368044}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|RuleBase:RU368044}.
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DR EMBL; KL358370; KFZ63716.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A094NB13; -.
DR Proteomes; UP000053620; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR PANTHER; PTHR45816:SF3; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01365; RYDR_ITPR; 1.
DR PRINTS; PR00779; INSP3RECEPTR.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|RuleBase:RU368044, ECO:0000313|EMBL:KFZ63716.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053620};
KW Transport {ECO:0000256|RuleBase:RU368044}.
FT DOMAIN 1..42
FT /note="RIH"
FT /evidence="ECO:0000259|Pfam:PF01365"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KFZ63716.1"
FT NON_TER 285
FT /evidence="ECO:0000313|EMBL:KFZ63716.1"
SQ SEQUENCE 285 AA; 33323 MW; A60C2019A8DEA4E1 CRC64;
RFLDYLSDLC VSNTTAIPVT QELICKFMLS PGNADILIQT KLVSTQMDNP LECPVISDDI
DEEEVWLYWI DSNKEPHGKA IRHLAQEAKE GTKADLEVLT YYRYQLNLFA RMCLDRQYLA
INQISAQLSV DLILRCMSDE SLPYDLRASF CRLMLHMHVD RDPQESVVPV RYARLWTEIP
TKITIHEYDS FTDSSRNEMK RKFALTMEFV EEYLKEVVNQ PFPFGDKEKN KLTFEVVHLA
RNLIYFGFYS FSELLRLTRT LLAILDIVQV PLSSYFERLS KFQDG
//
