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Database: UniProt
Entry: A0A094P3M6_9ACTN
LinkDB: A0A094P3M6_9ACTN
Original site: A0A094P3M6_9ACTN 
ID   A0A094P3M6_9ACTN        Unreviewed;       248 AA.
AC   A0A094P3M6;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   28-JUN-2023, entry version 31.
DE   RecName: Full=indole-3-glycerol-phosphate synthase {ECO:0000256|ARBA:ARBA00012362};
DE            EC=4.1.1.48 {ECO:0000256|ARBA:ARBA00012362};
DE   Flags: Fragment;
GN   ORFNames=GM47_1095 {ECO:0000313|EMBL:KGA05427.1};
OS   actinobacterium acIB-AMD-6.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=1504321 {ECO:0000313|EMBL:KGA05427.1, ECO:0000313|Proteomes:UP000029266};
RN   [1] {ECO:0000313|EMBL:KGA05427.1, ECO:0000313|Proteomes:UP000029266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ghai R., Mizuno C.M., Picazo A., Camacho A., Rodriguez-Valera F.;
RT   "Key roles for freshwater Actinobacteria revealed by deep metagenomic
RT   sequencing.";
RL   Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+)
CC         = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866; EC=4.1.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00001633};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000256|ARBA:ARBA00004696}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGA05427.1}.
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DR   EMBL; JNSH01000007; KGA05427.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A094P3M6; -.
DR   PATRIC; fig|1504321.4.peg.219; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000029266; Unassembled WGS sequence.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   HAMAP; MF_00134_A; IGPS_A; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045186; Indole-3-glycerol_P_synth.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth_dom.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR22854:SF2; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; 1.
DR   PANTHER; PTHR22854; TRYPTOPHAN BIOSYNTHESIS PROTEIN; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW   Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Tryptophan biosynthesis {ECO:0000256|ARBA:ARBA00022822}.
FT   DOMAIN          11..245
FT                   /note="Indole-3-glycerol phosphate synthase"
FT                   /evidence="ECO:0000259|Pfam:PF00218"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:KGA05427.1"
SQ   SEQUENCE   248 AA;  26636 MW;  D737D1EE9098BCE3 CRC64;
     DGVLEDVNHR IIPISQLQEQ LQGAPKLRGA YESLSKDGMR LIAEVKRSSP SKGDLAAISD
     PVELASKYQE GGADVISVLT EGRRFKGSIA DLLAVRSAVD LPVLRKDFIV TEFQVYESRI
     LGADLMLLIV AGLSKSKLVD FYQLAQGLGM DVLVEIHNLS EAEAALDIGA NIIGVNSRNL
     KTLEVDHENF QRILPQLPAT VIKVAESGIS SPAQVEAVSN LGANAVLIGE SLVKAGNPVH
     TIKQLLNR
//
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