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Database: UniProt
Entry: A0A094WJY2_BACAO
LinkDB: A0A094WJY2_BACAO
Original site: A0A094WJY2_BACAO 
ID   A0A094WJY2_BACAO        Unreviewed;       296 AA.
AC   A0A094WJY2;
DT   26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT   26-NOV-2014, sequence version 1.
DT   11-DEC-2019, entry version 24.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   ORFNames=AJ85_07325 {ECO:0000313|EMBL:THG88350.1}, BALCAV_0206720
GN   {ECO:0000313|EMBL:KGA98084.1};
OS   Bacillus alcalophilus ATCC 27647 = CGMCC 1.3604.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=1218173 {ECO:0000313|EMBL:KGA98084.1, ECO:0000313|Proteomes:UP000002754};
RN   [1] {ECO:0000313|EMBL:KGA98084.1, ECO:0000313|Proteomes:UP000002754}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV1934 {ECO:0000313|EMBL:KGA98084.1,
RC   ECO:0000313|Proteomes:UP000002754};
RX   PubMed=25395643;
RA   Attie O., Jayaprakash A., Shah H., Paulsen I.T., Morino M., Takahashi Y.,
RA   Narumi I., Sachidanandam R., Satoh K., Ito M., Krulwich T.A.;
RT   "Draft Genome Sequence of Bacillus alcalophilus AV1934, a Classic
RT   Alkaliphile Isolated from Human Feces in 1934.";
RL   Genome Announc. 2:0-0(2014).
RN   [2] {ECO:0000313|EMBL:THG88350.1, ECO:0000313|Proteomes:UP000297014}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 1.3604 {ECO:0000313|EMBL:THG88350.1,
RC   ECO:0000313|Proteomes:UP000297014};
RA   Yang J., Diao L., Yang S.;
RT   "Draft genome sequencing of Bacillus alcalophilus CGMCC 1.3604.";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC         Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGA98084.1}.
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DR   EMBL; ALPT02000016; KGA98084.1; -; Genomic_DNA.
DR   EMBL; JALP01000397; THG88350.1; -; Genomic_DNA.
DR   RefSeq; WP_003320571.1; NZ_JALP01000397.1.
DR   STRING; 1218173.BALCAV_0206720; -.
DR   EnsemblBacteria; KGA98084; KGA98084; BALCAV_0206720.
DR   OrthoDB; 1280729at2; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000002754; Unassembled WGS sequence.
DR   Proteomes; UP000297014; Unassembled WGS sequence.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002754}.
FT   DOMAIN          3..184
FT                   /note="Prephenate dehydratase"
FT                   /evidence="ECO:0000259|PROSITE:PS51171"
FT   DOMAIN          203..278
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   SITE            177
FT                   /note="Essential for prephenate dehydratase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001500-2"
SQ   SEQUENCE   296 AA;  32989 MW;  BF766B6764469F37 CRC64;
     MTKVAYLGPK GTFTEIAARA VFPQSSHIPY QTIPTCMDAV FEGEADLAVV PIENAIEGSV
     NLTLDYLIHK KRLPIIGSIT VPVAQHLLRS KWQKENGKTE PKKVISHPHA IAQCHDYLQL
     RYPQIEFEYM NSTATAAKWI SEHPEENVLG IANDLAAAEY NLDIVEQNIH DFDNNRTRFL
     VLAKENHVYQ VQGPFKLGDK TTLMVTLPSD FSGALHQVLS AFAWRRLNLS KIESRPTKTG
     LGNYFFIIDV DQLVDDVLIP GVVAELETLG CGVEILGSYE SFSLTEVKEG ISHEVT
//
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