ID A0A094ZHJ3_SCHHA Unreviewed; 732 AA.
AC A0A094ZHJ3;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=E3 ubiquitin-protein ligase {ECO:0000313|EMBL:KGB33357.1};
GN ORFNames=MS3_01518 {ECO:0000313|EMBL:KGB33357.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB33357.1};
RN [1] {ECO:0000313|EMBL:KGB33357.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KL250544; KGB33357.1; -; Genomic_DNA.
DR RefSeq; XP_012793122.1; XM_012937668.1.
DR AlphaFoldDB; A0A094ZHJ3; -.
DR STRING; 6185.A0A094ZHJ3; -.
DR EnsemblMetazoa; XM_012937668.2; XP_012793122.2; MS3_0011854.
DR GeneID; 24589267; -.
DR KEGG; shx:MS3_00005853; -.
DR CTD; 24589267; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR025754; TRC8_N_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22763; RING ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR22763:SF195; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13705; TRC8_N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 40..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 663..703
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 732 AA; 83450 MW; C1A8265399442319 CRC64;
MFTNYMSLLY TITLPTFPPA LYSFSTYFSS SSSSSSLSLL IRWHCILGCL LLSTSLLFML
INSIFRRIPP YKYFIIIILY ISVLFISSLP IIIKSSSIEL TRSDNAKSLR MMMITTTTTA
NDKHSFHTNV IYGLNNFSST WLFYVYTMVK PNCCVKQSNV NSNWQSLCLP TNIHLFSSNE
NIVHDVTIVS EAAYRYDIIL LTCSYGLLCI YILLLLYCLS ITDIYEIFMS CVNIELELYR
LGLVDYITFH WNRLDVPQIL MYFWSFKLVS VIILGPVCWE IIPTGDVNVD EISAKLFNSS
TLNEYSNLDT ANQSTLSILY TRLFVGLFVH GSETWLSVCG AAAFFGALAT IFVSILVFLL
DPSRTGTARL AVVAAEAPAD PHTWNVIDDP ALALDQNDVI AMELLASTGW NCAVVFLFLA
FQSDMPNLPP VYRASCSMYG IMVLVIACIH PIQALIKSFL LRLGAPGQQT NWSEHVRPLC
FCVVLIFAAF NMFTCLPRIL TNDKLDYIRN MNHSENASYL AVLSHIGSSE EAILARRLRI
FLSGCQLLIS LVVTLIEYAI YQYSYRYPNW TGFQPTIFWT KVISSVIDYF ISLLSFLTVC
WLVFYDSFGV CRLFIICCYF SLVLYPSARR AYIWIKWRLL CTKRMNDLVN PSKIQLERYG
DTCPICFAEM TITTAKITRC GHLYHSECLI QWMKHKLTCP ICQSDLLSTR VTNKRREVTS
ARMQETIVGE QN
//
