ID A0A094ZHL2_SCHHA Unreviewed; 629 AA.
AC A0A094ZHL2;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Potassium voltage-gated channel protein Shaker {ECO:0000313|EMBL:KGB33382.1};
DE SubName: Full=Putative voltage-gated potassium channel {ECO:0000313|EMBL:KAF1315843.1};
GN ORFNames=MS3_0015728 {ECO:0000313|EMBL:KAF1315843.1}, MS3_01541
GN {ECO:0000313|EMBL:KGB33382.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB33382.1};
RN [1] {ECO:0000313|EMBL:KGB33382.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1315843.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMPZ02000586; KAF1315843.1; -; Genomic_DNA.
DR EMBL; KL250545; KGB33382.1; -; Genomic_DNA.
DR RefSeq; XP_012793143.1; XM_012937689.1.
DR AlphaFoldDB; A0A094ZHL2; -.
DR STRING; 6185.A0A094ZHL2; -.
DR EnsemblMetazoa; XM_012937689.1; XP_012793143.1; MS3_0015728.
DR OrthoDB; 1478695at2759; -.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:UniProt.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003972; K_chnl_volt-dep_Kv1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF254; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR PRINTS; PR01496; SHAKERCHANEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000313|EMBL:KAF1315843.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 159..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..128
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
SQ SEQUENCE 629 AA; 73313 MW; 63403C9961024B28 CRC64;
MCRCVTDQIK TFNFGCSHGQ LKVRMTDQRI VINVSGLRFE THTDTLNRFP NTLLGCPFRR
SRYYDSLRNE YFFDRNRPSF DAILYFYQSG GRLRRPVNVP IDVFTEEIKF YDLGEEIFER
YREDEGFTKE DIHILPKNKF QRKVWLLFEY PESSTAARCV AIVSLLVILI SIIIFCVETL
PHFRHYELQF IEDSNELPII SAVDTPQVTG TLFILESICV VWYTFELLIR FAACPQKLAF
FRQVMNLIDV VSIIPYAISI GALLAEANKG QNQAMSLAIL RVIRLVRVFR IFKLSRHSKG
LQVLGRTLKA SFRELCLLCF FLFVCVVLFS AAVYFAEVDA SEEQFPSIID AFWWAVVTMT
TVGYGDMRPV TMWGKIVGSM CAIAGVLTIA LPVPVIVSNF NYFYHRESES EELTTYVHVS
DDQKGFNYPD NKALGNFHDE TLEYRNEEKY KGRKAAVILR QSFSQPSDRE RVSSVLSSTL
KNLEVEHEEV SSCIDSLGEL DNLCMEARNS QVNTNQASIS YRHHHQAFQE VMQKHDMQTQ
RFKDLYPQQL IASNNKRISL LTHSIYIYIY IYIFIDVYHV CSVGCYFPYY SDLLNCRIYK
YWIHNNQVNY IFTQAFNIYI YLFKTPVFK
//
