ID A0A094ZI54_SCHHA Unreviewed; 613 AA.
AC A0A094ZI54;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Prospero homeobox protein 2 {ECO:0000313|EMBL:KGB32579.1};
GN ORFNames=MS3_00725 {ECO:0000313|EMBL:KGB32579.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB32579.1};
RN [1] {ECO:0000313|EMBL:KGB32579.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KL250509; KGB32579.1; -; Genomic_DNA.
DR RefSeq; XP_012792360.1; XM_012936906.1.
DR AlphaFoldDB; A0A094ZI54; -.
DR EnsemblMetazoa; XM_035734160.1; XP_035589084.1; MS3_0020444.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.10.500; Homeo-prospero domain; 1.
DR InterPro; IPR023082; Homeo_prospero_dom.
DR InterPro; IPR037131; Homeo_prospero_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR039350; Prospero_homeodomain.
DR PANTHER; PTHR12198:SF0; HOMEOBOX PROTEIN PROSPERO; 1.
DR PANTHER; PTHR12198; HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26; 1.
DR Pfam; PF05044; HPD; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51818; HOMEO_PROSPERO; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:KGB32579.1};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000313|EMBL:KGB32579.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 499..613
FT /note="Prospero"
FT /evidence="ECO:0000259|PROSITE:PS51818"
SQ SEQUENCE 613 AA; 71579 MW; C74F80F25BE73207 CRC64;
MESYSEDERN FQTPEYLKPK FNGLEGKYIH STPLSQSNPY PVFHSMSSGF TGYKDILTNE
KTTPLYIPLS DEGYSSVGSG STPTGFSNNL PTSELINQYK DYGSVECIHN SINQKEKLEI
VALELLNQAR LIPNYSCHRH LHNRNNLGIN EVNDKSQLSY YKELNDKYHS LLQSNIKYGN
YNYPSMINQN NECINLSQQD LNCTKLLSSI NINNLQYQNN KQSFNDQLDY LKPFEKINKT
IKNDNNIDTD QSVESRNQIC NQILNQVRRE MIRLIDNSMH QLETYLQNYH YKDWYNSSTI
LNYCNSMKSV QFDGIQDCDV TPLNLKFTKN NNDIELENVN NKQSNQNQSS EVEFIPNDIV
SSEQESANSK CTIITSKESS TYSTRIKPLR YTTTTTNNKT RRLRIHQFNS QLFVDRNQTR
KLNKLSPSCN KRRLNNDIEE FPNKIPHLDE SLDLRIHQND HEDNNNNNKT DLIISSDNHS
SNCSQTRLKR SIINSQTKTA TLSAAHLKKA KMMFMYSRYP TSSLLKSYFP EVCFNRGSTA
QLVKWFSNFR EFFYIQIEKF VRQQKATGLK KADDIRLSRE HELIRSMETH FNKGDEIEYY
MILTVNAIMY YRL
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