ID A0A094ZI85_SCHHA Unreviewed; 1107 AA.
AC A0A094ZI85;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Phosphatidylinositol 4-kinase beta {ECO:0000256|ARBA:ARBA00039877};
GN ORFNames=MS3_00752 {ECO:0000313|EMBL:KGB32614.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB32614.1};
RN [1] {ECO:0000313|EMBL:KGB32614.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00036767};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19878;
CC Evidence={ECO:0000256|ARBA:ARBA00036767};
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004450}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004450}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00037860}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037860}.
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DR EMBL; KL250510; KGB32614.1; -; Genomic_DNA.
DR RefSeq; XP_012792387.1; XM_012936933.1.
DR AlphaFoldDB; A0A094ZI85; -.
DR STRING; 6185.A0A094ZI85; -.
DR EnsemblMetazoa; XM_035733903.1; XP_035590295.1; MS3_0019993.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KGB32614.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1076..1101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 878..1107
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 523..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 124134 MW; 886050E62813A56C CRC64;
MPDISEYRLG SACRINNSDQ FSEKAGSEAS ILDPSGSNAL KLEECIVSVQ ELHHVVNDKA
SSDDNGSNNN NPNMEDVTCC CHDSRNECGI LNDSNSSSWL RRLFTSSLFN LDMTIQYLFK
SEDVNVQMYL ADRLFGFPES DVDFYLLQLV SLYEKSPSLA EHLTNYFIYR CTKSVSFAIN
LVWLLDSFSS HSYNPLKRVS SILLNRPSSV PIFSYVSNQL YLMNSSDNSQ SINSNSNNSK
FIKLKSSSSA ITPLQELDYH NSNNGDENYN TNVVPTPNTT TTNNSTELSN DNRFVYTAQT
LRDLLLPIDE TTWGSFIPQS IVNGSYNMGS YNNVNTHYTH NTSSPSSNCK LSPNIHHNIG
HKRSTSDVTN KSRHRVVMDQ LDLMNNTETN QTITTITSNP NRWSSSQDSA VCLSTIDDVV
NNPITTISNI TNQISLNSIC PIINHLSNQT NPLLNENRHS LHQLHLNNLN QNPIKSSMSM
NKIITKEILP QSCLPKHSRS SVNLQQLNSS LCIMNDDNSA QIKSSSSLNQ TATVRGENNH
RNDVDRNLSS YSTNNITSDL MLGSLEGVPV LTTITLTKTK SINEARNNPT HTMESCSSTT
ESSSPLDSVP RIIPEWDFVD GLLRIARRLV PISPKEQRTA YLQAELANLN LHLPARVWLP
VNKAGHIVLR IPPTAAVCLN SKDKAPFLIY VEILCCDDPS IISLPSRPIT AASSKSSNSL
SAVYPWNPNS HTGCFSSNEI TENHEINVNT RTSDELSLRS SSISSNVSLS EELINPIEFN
HHQHQHPHYH LTIDEMDERK EHTTKCTHDQ FELNETIMKD DSFTATDSIT VTNANRSKSP
IYIGAGEIRN RLKEQCELQP HKSFRCDPED PSAAVLKEPW HVKCERIRAT SPWGSLPGWI
LTSAIVKVGD DLRQEQLAYQ LLTVLKNIWS MEYVPLWLRP LTVVVISSDS GFIEPVPDTV
SFHQIKRHAH LSLLDYMHRE HGGDNSEEFL TAQRNFLHSC AAYCLVGYLF QVKDRHNGNI
LLDNQGHVIH IDYGFILSSS PGKNLGFETS PFKLTLEQID VIGGLNSDLF EYFKFLLLRG
LLAALVYSFI EFPFFSFFFG WGGMGSI
//
