ID A0A094ZMI7_SCHHA Unreviewed; 959 AA.
AC A0A094ZMI7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=G-protein-signaling modulator 2 {ECO:0000313|EMBL:KGB35885.1};
GN ORFNames=MS3_04154 {ECO:0000313|EMBL:KGB35885.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB35885.1};
RN [1] {ECO:0000313|EMBL:KGB35885.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SIMILARITY: Belongs to the GPSM family.
CC {ECO:0000256|ARBA:ARBA00006600}.
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DR EMBL; KL250725; KGB35885.1; -; Genomic_DNA.
DR RefSeq; XP_012795650.1; XM_012940196.1.
DR AlphaFoldDB; A0A094ZMI7; -.
DR STRING; 6185.A0A094ZMI7; -.
DR GO; GO:0030695; F:GTPase regulator activity; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR45954; LD33695P; 1.
DR PANTHER; PTHR45954:SF1; LD33695P; 1.
DR Pfam; PF02188; GoLoco; 3.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00390; GoLoco; 3.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50877; GOLOCO; 3.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 226..259
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 543..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 959 AA; 105564 MW; 7FFBC8D12441A7AE CRC64;
MTYSSSTIPT PCLDLAMEGE RFCREGDWNK GISYFLKALA IGTDDLSCLS VVYCQLGNAY
FYQQDYARAL EYHRWNLALA RRMGDGIGEA FATGNLGNTL QMMGKYDEAI MCFTHELAIA
RQLNDKRTEA GALYNLGSVY QAKGKQWLPD SGEFPADAVK AQRKAAEYYK MGLELVRALG
DRPAEGRALG SLANAYYLLS NFTEAIECYR ERLKIAKEFG DLTAQRRAHS NIGNAFIFLA
DFNAAVEHYR EALQLSVRLK DTSLEAQACF SLGNTFILLR DPSTAVVFLL RHLIIARGLF
DRIGEGRAHW SLANAYTALK RYDLALRCSK RHRRIARQLG DTTGYMTAQL MIGEICNLMT
STQTECSTLI GASCKNDQTD SQSNNSNSTI NYSSVQQSCL LDINNSKLNE NILFLKNNHK
LPCGANNNKC CIDGNNNSVS TNTTTISNPT NTILTNNSCT DINFSNNPPT DLHITDGSNS
SLINGLISQS LLDSSKTIDP SANTDVVSSR IEIKSSQSTV TSNFSTTTVP SPTTVTANII
DSNHTTENHS HKVVINNDNG NDDDNNQDDL DLELDKDLEN ELLENYEGIL ETVEFVTVTE
DGQTVTSQMG CLDVPTPVLS ESKKENMVEF YLSAPSFRPS LSQQIDIPNL QDIEGNLESI
ESMSQMNRNS NLSSENLDSG NTCNTVGTSS SAVAVAAASL VEEERSVDQQ EMFFSLLLES
QSRRMDEQRC YLRTTGQGTP PIQSTETNSV QESNNVQLSS GNSRRTPDYD NSSLRSQIGT
NEEAFFDLIE GVQGARMNDQ RANLSVFPGL RSGPGLHLLD SNNNTTTPAN NNNNRYFGST
NSVFKSTSSC ASDGLPEPRL RNNSIQSHTN PTHRNNDNGD GSRGIRQPIS TSEATTITTS
NSHRELTLYT SSGAFNNLTN RCSVPAIVDD DDGDANDLFA LIQRVQSTRL DEQRCRPPL
//
