ID A0A094ZRR9_SCHHA Unreviewed; 758 AA.
AC A0A094ZRR9;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Bcl-2 homologous antagonist/killer {ECO:0000313|EMBL:KGB36852.1};
GN ORFNames=MS3_05170 {ECO:0000313|EMBL:KGB36852.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB36852.1};
RN [1] {ECO:0000313|EMBL:KGB36852.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|ARBA:ARBA00009458}.
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DR EMBL; KL250818; KGB36852.1; -; Genomic_DNA.
DR RefSeq; XP_012796614.1; XM_012941160.1.
DR AlphaFoldDB; A0A094ZRR9; -.
DR STRING; 6185.A0A094ZRR9; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd06845; Bcl-2_like; 1.
DR Gene3D; 1.10.437.10; Blc2-like; 1.
DR InterPro; IPR036834; Bcl-2-like_sf.
DR InterPro; IPR046371; Bcl-2_BH1-3.
DR InterPro; IPR026298; Bcl-2_fam.
DR InterPro; IPR002475; Bcl2-like.
DR PANTHER; PTHR11256:SF56; BCL-2 BCL-2 HOMOLOGY REGION 1-3 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11256; BCL-2 RELATED; 1.
DR Pfam; PF00452; Bcl-2; 1.
DR SMART; SM00337; BCL; 1.
DR SUPFAM; SSF56854; Bcl-2 inhibitors of programmed cell death; 1.
DR PROSITE; PS50062; BCL2_FAMILY; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 732..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 572..671
FT /note="Bcl-2 Bcl-2 homology region 1-3"
FT /evidence="ECO:0000259|SMART:SM00337"
FT REGION 24..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 83906 MW; F114C09F351EA83F CRC64;
MSTDGTADGP LEADSSWISS KTSFMTISDP SDSSTPNANS SLDETFASNK FSPNSFANSS
PKSDGIEDND YDNGDKDEEE EQVKQKKKTG VTLVYAPEKP ANIFKSSQNS IVTPQPNQKV
IIIRPNQGND NNDSENNSLT KENGIGSTTA SSIDKILYSS EENLSKLNGE HDLKQLNNSN
SVFYNNSFDE FSSNNGISDY KDISDNNNNN NNNNNNNNNN NNNNNNNSNN NNLSNNDSKY
DNSGSILSTP TVLTSLDNHN DSSVLSMGSK SLSKEILNDD DNTNNNNSNN NQSYANSTIS
FDANNDITGI VLQNHEEIAK NTSSIDQNEK YMSALKPVLS SPSNHLIDSD QESKLLTDNS
FIKSNLSNIA QMNSELDDEV TKTVLNISDQ YKKTVNKFVE QSMPTYLDRC SPAQIVAVTG
GAPPDIIRNI EEDLDEDNDN VIEVLNTDVE HEANPSASSS TNPGNIVRQR GHPSESLKSP
KPVVSKLTPS TPEEVDASSE LVFSNFMIDR YRLEVSASAQ ASSSQSTASA SASIHVTDMG
QQAESEDPVS HQLSSLPRAE PHSVEAIVAR NLAEIGDEIN RIYGPRLDRM IKLLPVEECP
LEMFYNVARV LFARGPTNWG QVITLFYFGY RLVVQRVKKG VTNAFYQVCR CLVSFCRQIN
IFVWIAQQGG WRILQFLQSH RTYDDKNINT KNHSTPSNMI SHTDENDQQN TSLNDHNTNN
PLFDHSNYDS SLFIPFILTS TSVVVIAVAV WFYLRRLK
//
