ID A0A094ZS79_SCHHA Unreviewed; 3518 AA.
AC A0A094ZS79;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 08-NOV-2023, entry version 44.
DE SubName: Full=Nucleosome-remodeling factor subunit BPTF {ECO:0000313|EMBL:KGB35929.1};
GN ORFNames=MS3_04213 {ECO:0000313|EMBL:KGB35929.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB35929.1};
RN [1] {ECO:0000313|EMBL:KGB35929.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
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DR EMBL; KL250729; KGB35929.1; -; Genomic_DNA.
DR RefSeq; XP_012795704.1; XM_012940250.1.
DR STRING; 6185.A0A094ZS79; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd15560; PHD2_3_BPTF; 2.
DR CDD; cd15532; PHD2_CHD_II; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 3.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT TRANSMEM 1932..1950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1957..1976
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 351..411
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 536..583
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 3283..3335
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 3342..3394
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 67..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1376..1397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1669..1714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1747..1788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2600..2703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2778..2798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2845..2879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2952..3076
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3134..3263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3401..3425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1533..1567
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2310..2337
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 113..127
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..675
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1022
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1448..1468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1669..1692
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1771..1788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2619..2633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2671..2695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2845..2876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2956..2979
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2980..3003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3014..3031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3045..3076
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3138..3153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3154..3195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3211..3248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3518 AA; 390626 MW; FD3234487F9A7E4D CRC64;
MDSLSAGTNG LAGGGAASAL AGVKKRTKVV FLNPVEIANW DQIKENSKQN VIGHNDLINY
EKMLKDDDST SVTATEARRQ SKRRGRPKGS RNGARKRPID PSQPWLDSSD SDEPNVGLED
ELDDDEYFRR LEEEKMREDA EEVSRKRREM EARAAARANA QGRRGSAKVD PLMTHQFQTP
VNSDSNLSCQ SGSQREFSNR NKKQRNYAAL AGFREVSDSD DLSELDDKGA GRSGFLQESD
YPRSLDDIHE QNEEDYQEPA SPFRQSILDM LPPPPSPVIP SNSEEDKSIL KCESLSVASS
NDLNALRTTV ANASINDPHT QKMLEMDPIE LRFRSPPLIL PSSANDLVCP REYILDVLSI
YEVLRRYGSL LRLSPFRLED FAASLISDEN SNLLAEAHMV LLKALLREDE ANGTAMCPVD
CRDSVNMTFY LLDRFTWPYL LANYLSSIKS TEAAARLSAA NTTTAAGSIG GPTGSGGADI
VLTAALFPPD LIPLNPGYPF VPIKSRIAVL RGLTSLFLAT GPVRGDILRE GLMTHEDYCR
VCHQSGEVLC CDGCTAVFHL HCLNPPLSSV PTTSWICPVC IRKRTPGVTD CLSEAEKSGV
AHYQEPIGKD RAGRLYWYIS RRLIIEPVDF SQCEPQLVGF HDGVFDSSWE MEYGRELMED
DPEVKDDEGD IDDNNNDDNN NANSTTDSAN NDSLNLTSKV SYCDSSQPIP TFNKQKNYKK
YQCNPSISYA NEPCVYYYSS IEQVMYIREL LSTEWEPWLC YRLDALLPRM RNEMAITQKL
TESGFLDFCS SRPNYKSVSI NNSDLNQGCN LTADSPDTVY VYSVLEVERA SFKKSTTSIK
THGETPDYPK TRLAIAASSL PSADVPIFPT LPKQLPALLN KQPSDLSACL ILTDENSCIV
GNGDQVITHM VKETSDDDVA TYPPTILEPQ EISTLHMLID PDWLPNSNEC CLLAYRFSDE
GNWRSWTNLY TSGVWTGEEC TAMPDSHRND DLSELKRTPS GTRNSNAVNN NNNNNNGNNS
TVTADDLISD SVNVALTRAQ HMEEKERRRL LSNKFNVSEL CTDMWAYIDP VELSNNFKLV
RDMMASVIEL PQFSDFDFTR YECWPASPHQ LLNLLRLTLC HFESKIPLAF YTPAWRAHRT
NWIKDVLHSK SPSDLAFLLA RLEASIRSVC FQRVWFNSLG HLTLERMTAS QREEDKRLRQ
FDRFSSTVNG GVGSSNINPA NLPTNLIRTK TPRPVRHTVW KTRGEEYRRL GGDGWMWLSA
TRSNAGRMAE HAVLIHPPIS SGRQLELTAT LSGNRLLLHR RGNPRGLQHG IGWGVCPEYL
QDQMPVKPPK ASECRGHVLH PITGIPLYLN PKRNPYIIPS DVLCSLNEQI LKSSTNNVQM
NPSSSSHIDD DAKKKYPDSG NMITVKKDEN NMNEDVMNDN FEKNKIDQLD GLHENCNASE
IKIEQRKDSL SGQTSSINNN TNDGKIINDD NKNPVLNISY CLSNRIHFPP PIDKEHSYPS
SSSSLSSSKR LRFRIDNLLE HRYIAAENDK KASLAALNAV SKLEAEIENL EKRHNEVVQR
LTTLGTEAQQ ARTAKAQAVK AKQTALLIKP SQPSTLAVGG VGSGNVVMTN SRLIQLNENS
NNTTNTTVTT FGGGKQLIQQ SVLTDQGVRY RVLAPRTVPN IHMNQVAFNP VQKTASTPNN
RTPQPTYRSN QKRRTNRNSD LSESDSDCDS VTANTGRVNS WSARENVPLR RSARRVRAVR
HDPDFVVDFE DDDEDDRLNA KGDDSDNFDP NDEIQGSSKK YSSQRRSQVV PKVVILKNNT
APYIYGNTAT TVKNKDNTNP RVLSIPPSTT TTGQRIILPA KLKTPTNTNE KSVSNNKTVS
LGNVKEGNNQ AVHLPPSQPS VNMPQGLRLV RIVRNPDGGT NIIPVAATDT ILSPTIEPLN
VNQTVDNSSK IFLLYIVSLF VCCFLMLHVL CFVTCHLFCL IFPLLNPLSF SPFIVLKIDY
PVITNTTGQS DLVPSSSTTG LNSFDSSDIH LVLNSSSTTG SNNVVTISKP SVILTTATTS
CELKPAITNT PLVSISVENE TSQQPITIST TNLQQCGIQL TDLITPATVS NTVSIPALIN
QPATVNIATV GKLKPPSANS VRFIIAPTVC TTATTTSDSS GSTNPPSQTP TITIVKASNQ
SGVSSDPNAV TSAVTSSFTP ILPRKPPPAI LRRTLAAAGS GGPSSTSLIL PVSSSSDYPQ
IVGTQQSSSL RTPSVASLVA TNTARQLVCG GFNRYISTGP SIRPVISDSQ GMSDLHQGRR
SIAKAQHIRH NSLIDEDPRF IMNNKSKVLI SDYKGLAQEL ESQINSLKSE LGKYQEIVNR
GSPVISSPYS LSLRNNADFD LNNKTFVNKF LRNNNKKTTN QAGKDYGTTT DAMLPQSLPY
VNDYAWPLPD SMSKDQCSSE QKQNMVLPKS SLFRINPHNL RLVILSAGRR EIPGYDVEKK
RLSQVNWLYP SSRPNFAECW RFRLSQIRMN SFQKDNHNNN ISFGLDLANL ALLLRTLWHC
IRWDDIMVEP DKDICVHDSN GRPCFKKILN VDDDDDDIDV SGVSGRYDDN KPYSVRRIVE
IQPLDRFWLQ ANYKVRITTT YPTRSNSSRR RKATDPSNRG RSTRGPSLQD SPEPDESSSR
RKGRRGGQRN AQGGKDPDYD PAVDEGWRVG VPCSNSSSRR QSRNNFRSYG RSSRGSFCDS
DDDGDPEFCG GRRGLQSQRN EVSVEEKWMS EDAVFLWEIS VFMNSLLPPK SNYPPISDSD
VSKMDPNDKT SQYVISTRLA SLPPDPSSNA STSATVTTTE VNKSLISPSN IEGYVEKNGF
LYDGGQPNGL LLNSSSSRSR STLASALQSG RMPVNSRSRS DDRSVSNNNS IPRPLSPNTL
EAKARARSIA ATNAARASVA ARRARFERAL LEQRVRSLKS QFCSRKRLIF NWAKSLADIA
VNEIKGAQQI SKADKFNENS SKKLEQSSTH PHHQTGEKLL TQKSRSNIVN QLNKSSSFSS
TLIPKKKIGR PSKTKNDNTT TTTTTTTITN KKNDVYHKRT KRKITPTFSS SLSSSDDENK
NPYVINNNNN NNKPINQSEL LANNRIPRKS ALNHEFIKLS KSYNKTTIKQ SPNRTNNKNR
LTMKLSLKQS KKLLTNNNNK DSDNDKNDDA DDNTTTITTH SSCSTASTSP GLGDDYGNNI
CQQKSTASTK TNRSSGTKTK RLKHESTNSD ASEHNYNVTG SMKSPKSSSV GEGGSKRGSS
SASGTGRSNK GGGRAKLSEK SDRNEIQIES ITNVLQDVSS NSSVYCVCKT PYNPSREYIG
CDLCRDWFHF ECVGLDPKDS DKLGDSWHCP DCKQAELKAN EMLYCVCRTP YEPTRVYIAC
DGCDEWYHPE CVGLTPEQAV NHTDTYLCPT CCQLSQHKTN TTTTTTKSSG KSKKSKKSNN
NHNAVTDQHK MSWPFIHSPD PLKFPIARSL DDSFNLPSVI INLKTDVYKT LGDFSFDMNR
LFTNSRLIYP KDTPEFNCTE IVEALFVQKM KLFKEENL
//
