ID A0A094ZSE7_SCHHA Unreviewed; 432 AA.
AC A0A094ZSE7;
DT 26-NOV-2014, integrated into UniProtKB/TrEMBL.
DT 26-NOV-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Hematopoietic lineage cell-specific protein {ECO:0000313|EMBL:KGB36014.1};
DE SubName: Full=Putative cortactin {ECO:0000313|EMBL:KAF1339357.1};
GN Name=HCLS1_1 {ECO:0000313|EMBL:KAH9580340.1};
GN ORFNames=MS3_00009022 {ECO:0000313|EMBL:KAH9580340.1}, MS3_0019224
GN {ECO:0000313|EMBL:KAF1339357.1}, MS3_04286
GN {ECO:0000313|EMBL:KGB36014.1};
OS Schistosoma haematobium (Blood fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6185 {ECO:0000313|EMBL:KGB36014.1};
RN [1] {ECO:0000313|EMBL:KGB36014.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22246508; DOI=10.1038/ng.1065;
RA Young N.D., Jex A.R., Li B., Liu S., Yang L., Xiong Z., Li Y.,
RA Cantacessi C., Hall R.S., Xu X., Chen F., Wu X., Zerlotini A., Oliveira G.,
RA Hofmann A., Zhang G., Fang X., Kang Y., Campbell B.E., Loukas A.,
RA Ranganathan S., Rollinson D., Rinaldi G., Brindley P.J., Yang H., Wang J.,
RA Wang J., Gasser R.B.;
RT "Whole-genome sequence of Schistosoma haematobium.";
RL Nat. Genet. 44:221-225(2012).
RN [2] {ECO:0000313|EMBL:KAF1339357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=31494670;
RA Stroehlein A.J., Korhonen P.K., Chong T.M., Lim Y.L., Chan K.G.,
RA Webster B., Rollinson D., Brindley P.J., Gasser R.B., Young N.D.;
RT "High-quality Schistosoma haematobium genome achieved by single-molecule
RT and long-range sequencing.";
RL Gigascience 8:0-0(2019).
RN [3] {ECO:0000313|EMBL:KAH9580340.1}
RP NUCLEOTIDE SEQUENCE.
RA Stroehlein A.J.;
RT "Chromosome-level genome assembly for S. haematobium.";
RL Submitted (JUN-2021) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:KAH9580340.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=35167626;
RA Stroehlein A.J., Korhonen P.K., Lee V.V., Ralph S.A., Mentink-Kane M.,
RA You H., McManus D.P., Tchuente L.T., Stothard J.R., Kaur P., Dudchenko O.,
RA Aiden E.L., Yang B., Yang H., Emery A.M., Webster B.L., Brindley P.J.,
RA Rollinson D., Chang B.C.H., Gasser R.B., Young N.D.;
RT "Chromosome-level genome of Schistosoma haematobium underpins genome-wide
RT explorations of molecular variation.";
RL PLoS Pathog. 18:0-0(2022).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMPZ02000017; KAF1339357.1; -; Genomic_DNA.
DR EMBL; AMPZ03000007; KAH9580340.1; -; Genomic_DNA.
DR EMBL; KL250737; KGB36014.1; -; Genomic_DNA.
DR RefSeq; XP_012795779.1; XM_012940325.1.
DR AlphaFoldDB; A0A094ZSE7; -.
DR STRING; 6185.A0A094ZSE7; -.
DR EnsemblMetazoa; XM_012940325.2; XP_012795779.1; MS3_0019224.
DR OrthoDB; 101008at2759; -.
DR Proteomes; UP000471633; Unassembled WGS sequence.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR003134; Hs1_Cortactin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10829; CORTACTIN AND DREBRIN; 1.
DR PANTHER; PTHR10829:SF23; CORTACTIN, ISOFORM A; 1.
DR Pfam; PF02218; HS1_rep; 4.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51090; CORTACTIN; 4.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000471633};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 375..432
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 48952 MW; 5685AC2A90938683 CRC64;
MSSNRNVDDE WETEPDFVND VTEKEQRWGS KTVIGSGHQA SIDMMALKEE VKQADRLAKL
KIAPKPAYGY GGQFGIEKDR MDKSAVDWNH IEVTEKHTSQ KDYAKGFGGK YGVERDRQDK
SSVGWDHKEA VEKHSSQKDY SVGFGGKFGV QTDRQDKSAL GWDHHEQSSH HPSQVDYSKG
FGGKFGLQTD RVDSSSVGWN DVSQTESHPS QLKASIFKPD GSLSNIRARF EQGINPNNVK
DSSGLTIAQQ RVLEEQTRWN AEREQQQQRE QQEDEEQSRG KSGSSDTVQS VSNNSVFTDT
IKPINNNTIH DHNWNKQVDS ENNMKSLHSQ EFTTFVESNQ FNNDKYNQLE DKNEPRTSSE
SHVHDNPVAS DDQVPEMFTV TAMYDYEAAE NDELTFKAGE IITEVEKIDA GWWKGVCRNK
VGLFPANYVK LE
//
